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Vaccination against the human papillomavirus (HPV) is a preventive strategy aimed at reducing the incidence of cervical cancer and other diseases associated with persistent infection by this virus. Despite the availability of safe and effective vaccines, immunization coverage continues to be variable in different contexts, especially when the decision to vaccinate depends on parents or legal guardians. In this sense, parental knowledge, beliefs and acceptance can influence the decision to immunize the school population. The objective of this protocol is to analyze the level of knowledge, beliefs and acceptance of parents or legal guardians, and its relationship with HPV immunization in primary school children in the township of Chitré, Herrera province, Panama. A quantitative, observational, cross-sectional and non-experimental study will be developed, with a descriptive-correlational scope. The population will be made up of 1229 parents or legal guardians of schoolchildren enrolled in public and private schools, from which a stratified probabilistic sample of 294 participants will be selected. The information will be collected through a questionnaire previously validated and adapted to the local context, complemented by the verification of the student's vaccination card. The data will be analyzed using descriptive and inferential statistics using the SPSS version 27 program. It is expected to generate evidence on parental factors associated with the acceptance of the HPV vaccine, which will contribute to the design of educational and promotion strategies, aimed at strengthening vaccination coverage in the Panamanian school context.