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This article emerges from the research called Evolution and Development of Architecture in the Province of Veraguas, offering a theoretical and graphic work, which integrates the methodology of architectural research and the existing historiographic information on buildings and cities in Veraguas. We organized the research chronologically, detailing it with information on the first Spanish mining towns founded in Veraguas, of which Santa María de Belén, La Concepción de Veragua, Santa Fe, Atalaya or San Miguel de Atalaya, Filipinas de Soná, stand out. Montijo, San Francisco de la Montaña, San Marcelo de La Mesa, Las Palmas, San Francisco Javier de Cañazas (Minas Santa Rosa-San Isidro), La Ermita de Río de Jesús, Nueva Alcudia, in which we detail the creation of them and its evolution. All the information has been the product of exhaustive research reviewing many bibliographic sources of the time. For many years, the Veraguas region has been a center of appreciation for its mineral riches, which have not only been known since the arrival of the Spanish, but also since pre-Hispanic times.