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Bioinformatics is a relatively new technical and scientific discipline, as it goes back a little more than three decades. One accepted description is that it is the relationship of mathematics and biology through informatics whose most important contribution is that it opened the doors of the genome for the understanding of the map of life by scientists. With the development of information systems, the construction of knowledge was exponentially enhanced. Computer science revolutionized the world of scientific research and the production of knowledge. What used to require decades of research discipline was reduced to years, thanks to digital tools and the global collaborative environments of the knowledge society. This characteristic has been decisive in confronting the pandemic produced by the coronavirus COVID-19. This article is a documentary review of the use of bioinformatics as a strategic ally to overcome the coronavirus and reduce it to an endemic disease, both from the design of studies and the use of techniques and tools provided by the discipline. General and academic open access search engines were reviewed, with the use of keywords without Boolean connectors by selecting a sample of academic research papers or specialized web pages, in Spanish, with specific inclusion characteristics. The main conclusion is the low production of research and medical research documents on the coronavirus in the Latin American region and the percentage absence of works of Panamanian origin.