An effective way to work the twelve principles of Green Chemistry, in theteaching of Chemistry, is through laboratory work done by students. In thiscontext, the present research is presented, which incorporates a green approachwithin the practical work of the course of Organic Chemistry for medicine students.A laboratory manual was developed to redesign the experimental activity underthis approach of clean processes and with the use of microscale techniques, inthe Faculty of Natural Sciences, Exact Sciences and Technology of theUniversity of Panama.The greenness evaluation of the experiments was carried out through the useof a Likert-type numerical scale, which allows to evaluate how green a processis, with the result that 56 % of the experiments showed a good green approach.An efficient green chemistry approach led to the reduced consumption of reagents,avoiding the prolonged and unnecessary exposure to them and, at the same time,diminishing the risk of accidents. The general utility of this methodology, whichpresents significant advantages over the traditional practical works, wasdemonstrated not only by incorporating the principles of Green Chemistry in eachexperiment, but reaching a more active participation of the students, because theyhave to be aware of all the procedure steps in order to obtain an appropriateevaluation about the green approach of a particular experiment.