Investment in science and technology is a key element for driving economic growth and sustainable development. This study analyzes the relationship between investment in science and technology (R&D) and Panama's Gross Domestic Product (GDP) during 2000-2020. A correlational design was applied through simple linear regression, using Econometric Views as a statistical tool. Data were obtained from Panama's National Institute of Statistics and Census. Results indicate a moderate positive relationship between both variables (R = 0.73, R² = 0.54), confirming that investment in science and technology explains 54% of GDP variability. However, this moderate association suggests the need to incorporate additional variables in future research to expand understanding of the phenomenon.