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This article addresses the complex situation surrounding irregular migration. The human drama unfolds as individuals traverse the most challenging point of the route: the Darien Jungle. Additionally, we present the reasons compelling them to migrate, the uncertainty they face throughout the journey, the humanitarian response, and the assistance provided by Panama through the National Border Service. This includes rescues for those who do not achieve their goal, shelters, unaccompanied minors, and crimes associated with this phenomenon, such as human trafficking. These topics shed light on a reality that not only impacts this continent but is also present and relevant in other regions. The research was conducted under the qualitative paradigm, employing content analysis, on-site observations, and interviews with key informants related to the attention processes of migrants in Panama.