Papel de la genética en las maloclusiones esqueléticas clase ll y clase lll.

Daniel Hernández; Katia Li; Aileen Nip

doi:10.48204/2710-7825.6924

Submitted February 17, 2025

Published 2025-02-21

Revisión bibliográfica

Vol. 5 No. 1 (2025): Contacto Científico

Role of genetics in class ll and clas lll skeletal malocclusions.

Daniel Hernández ⁺⁻
Katia Li ⁺⁻
Aileen Nip ⁺⁻

DOI https://doi.org/10.48204/2710-7825.6924

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DOI: 10.48204/2710-7825.6924

Published: 2025-02-21

How to Cite

Hernández , D., Li , K., & Nip , A. (2025). Role of genetics in class ll and clas lll skeletal malocclusions. Contacto Científico, 5(1), 19–28. https://doi.org/10.48204/2710-7825.6924

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

Class II malocclusions are manifested by maxillary prognathism, mandibular retrusion, or a combination of both; while class III malocclusions are characterized by maxillary retrusion, mandibular protrusion, or both. Both malocclusions have a multifactorial etiology that can be influenced by genetic and environmental factors. The objective of this article is to identify the genes involved in the manifestation of these growth alterations associated with skeletal class II and class III malocclusions. Methods and materials: the information search was carried out in the PubMed, EBSCO, and Google Scholar databases, considering articles published in the last 10 years. Results: 8 articles were selected. Conclusions: Class II malocclusions are associated with variants in the genes ACTN3, FGFR2, MSX1, and MYO1H. Class III malocclusions due to variants in the genes ADAMTSL, MYO1H, BMP3, GHR, FGF7, FGF10, SNAI3 and ADAMTS2.

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References

AlShahrani I, Dawasaz AA, Syed S, Ibrahim M, Togoo RA. Three-dimensional palatal
anatomic characteristics’ correlation with dermatoglyphic heterogeneity in Angle
malocclusions. Angle Orthod. 2019;89(4):643–50. doi:10.2319/091718-675.1.
Atteeri A, Neela PK, Mamillapalli PK, Sesham VM, Keesara S, Chandra J, Monica U, Mohan
V, Miryala S, Khan FA, Makthal P. Analysis of MYO1H gene polymorphism in
skeletal class-III malocclusion due to mandibular prognathism. Glob Med Genet.
;8(4):156–61. doi:10.1055/s-0041-1731066.
Cunha A, Nelson-Filho P, Marañón-Vásquez GA, de Carvalho Ramos AG, Dantas B,
Sebastiani AM, Silvério F, Omori MA, Silva Rodrigues A, Cardoso Teixeira E,
Carvalho Levy S, de Araújo MC, Matsumoto MAN, Lourenço Romano F, Antunes
LAA, da Costa DJ, Scariot R, Santos Antunes L, Vieira AR, Küchler EC. Genetic
variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial
skeletal patterns. Arch Oral Biol. 2018;97:218–26.
doi:10.1016/j.archoralbio.2018.09.018.
Dehesa-Santos A, Iber-Diaz P, Iglesias-Linares A. Genetic factors contributing to skeletal
class III malocclusion: A systematic review and meta-analysis. Clin Oral Investig.
;25(4):1587–1612. doi:10.1007/s00784-020-03731-5.
Jiang Q, Mei L, Zou Y, Ding Q, Cannon RD, Chen H, Li H. Genetic polymorphisms in
FGFR2 underlie skeletal malocclusion. J Dent Res. 2019;98(3):295–303.
doi:10.1177/0022034519872951.
Kantaputra PN, Pruksametanan A, Phondee N, Hutsadaloi A, Intachai W, Kawasaki K,
Ohazama A, Ngamphiw C, Tongsima S, Ketudat Cairns JR, Tripuwabhrut P.
ADAMTSL1 and mandibular prognathism. Clin Genet. 2019;95(4):507–15.
doi:10.1111/cge.13519.
Moreno Uribe LM, Miller SF. Genetics of the dentofacial variation in human malocclusion.
Orthod Craniofac Res. 2015;18(Suppl 1):91–9. doi:10.1111/ocr.12083.
Vieira AR. Orthodontics and genetics. Dental Press J Orthod. 2019;24(2):92–7.
doi:10.1590/2177-6709.24.2.092-097.sar. PMCID: PMC6526758. PMID: 31116292.
Yao S, Zhou X, Vona B, Fan L, Zhang C, Li D, Yuan H, Du Y, Ma L, Pan Y. Skeletal class
III malocclusion is associated with ADAMTS2 variants and reduced expression in a
familial case. Int J Mol Sci. 2022;23(18):10673. doi:10.3390/ijms231810673.
Zebrick B, Teeramongkolgul T, Nicot R, Horton MJ, Raoul G, Ferri J, Vieira AR, Sciote JJ.
ACTN3 R577X genotypes associate with Class II and deep bite malocclusions. Am J
Orthod Dentofacial Orthop. 2014;146(5):603–11. doi:10.1016/j.ajodo.2014.07.021.

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[1] AlShahrani I, Dawasaz AA, Syed S, Ibrahim M, Togoo RA. Three-dimensional palatal

[2] anatomic characteristics’ correlation with dermatoglyphic heterogeneity in Angle

[3] malocclusions. Angle Orthod. 2019;89(4):643–50. doi:10.2319/091718-675.1.

[4] Atteeri A, Neela PK, Mamillapalli PK, Sesham VM, Keesara S, Chandra J, Monica U, Mohan

[5] V, Miryala S, Khan FA, Makthal P. Analysis of MYO1H gene polymorphism in

[6] skeletal class-III malocclusion due to mandibular prognathism. Glob Med Genet.

[7] ;8(4):156–61. doi:10.1055/s-0041-1731066.

[8] Cunha A, Nelson-Filho P, Marañón-Vásquez GA, de Carvalho Ramos AG, Dantas B,

[9] Sebastiani AM, Silvério F, Omori MA, Silva Rodrigues A, Cardoso Teixeira E,

[10] Carvalho Levy S, de Araújo MC, Matsumoto MAN, Lourenço Romano F, Antunes

[11] LAA, da Costa DJ, Scariot R, Santos Antunes L, Vieira AR, Küchler EC. Genetic

[12] variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial

[13] skeletal patterns. Arch Oral Biol. 2018;97:218–26.

[14] doi:10.1016/j.archoralbio.2018.09.018.

[15] Dehesa-Santos A, Iber-Diaz P, Iglesias-Linares A. Genetic factors contributing to skeletal

[16] class III malocclusion: A systematic review and meta-analysis. Clin Oral Investig.

[17] ;25(4):1587–1612. doi:10.1007/s00784-020-03731-5.

[18] Jiang Q, Mei L, Zou Y, Ding Q, Cannon RD, Chen H, Li H. Genetic polymorphisms in

[19] FGFR2 underlie skeletal malocclusion. J Dent Res. 2019;98(3):295–303.

[20] doi:10.1177/0022034519872951.

[21] Kantaputra PN, Pruksametanan A, Phondee N, Hutsadaloi A, Intachai W, Kawasaki K,

[22] Ohazama A, Ngamphiw C, Tongsima S, Ketudat Cairns JR, Tripuwabhrut P.

[23] ADAMTSL1 and mandibular prognathism. Clin Genet. 2019;95(4):507–15.

[24] doi:10.1111/cge.13519.

[25] Moreno Uribe LM, Miller SF. Genetics of the dentofacial variation in human malocclusion.

[26] Orthod Craniofac Res. 2015;18(Suppl 1):91–9. doi:10.1111/ocr.12083.

[27] Vieira AR. Orthodontics and genetics. Dental Press J Orthod. 2019;24(2):92–7.

[28] doi:10.1590/2177-6709.24.2.092-097.sar. PMCID: PMC6526758. PMID: 31116292.

[29] Yao S, Zhou X, Vona B, Fan L, Zhang C, Li D, Yuan H, Du Y, Ma L, Pan Y. Skeletal class

[30] III malocclusion is associated with ADAMTS2 variants and reduced expression in a

[31] familial case. Int J Mol Sci. 2022;23(18):10673. doi:10.3390/ijms231810673.

[32] Zebrick B, Teeramongkolgul T, Nicot R, Horton MJ, Raoul G, Ferri J, Vieira AR, Sciote JJ.

[33] ACTN3 R577X genotypes associate with Class II and deep bite malocclusions. Am J

[34] Orthod Dentofacial Orthop. 2014;146(5):603–11. doi:10.1016/j.ajodo.2014.07.021.

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