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The main objective of the article is to describe the main actions carried out by the Panamanian state during the beginning of the republic for the forced integration of indigenous peoples, particularly the Gunas of the Gunayala region (San Blas). Theoretical interpretations are also presented, divided into categories such as autonomy, denial, and conquest to analyze and interpret the social movement called the Dule Revolution of 1925. The research design is descriptive of a bibliographic and documentary nature, where the events before, during and after with the data and with specific dates that occur. The Dule Revolution of 1925 is caused by situations, tensions directed by the national government starting in 1903, through institutions such as churches, education and national security (national police).