In order to determine the presence and prevalence of blood parasites in resident and migratory birds in Punta Santa Bárbara, Darién National Park, 271 blood samples taken from 126 birds of 43 species were collected. With a total of 24 smears or 19.05% of positive samples for some type of blood parasite, it was determined that the most common of these parasites found was Haemoproteus (11.90%), Plasmodium (5.56%), followed by Leucocytozoon (4.76%) and microfilariae belonging to helminths with (0.79%) prevalence. Using the Shannon-Wiener index, it was determined that the diversity of parasites in the rainy season is similar to that recorded in the dry season. Using a Chi-square test, it was determined that Haemoproteus sp., Is the parasite most frequently in positive samples, while microfilariae are recorded less frequently. The frequency of parasitized and non-parasitized birds was evaluated according to the mass of the individual by means of a Chi-square test, finding for this study a significant difference in the number of birds parasitized according to the mass of the individual, birds with parasites have greater weight This study is the first on parasitology for the birds of the province of Darien, therefore, everything that we report here is new for this side of the country. So far there are only 4 previous studies of blood parasites in birds for all of Panama.