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Intrapreneurship is the entrepreneurial activity developed within organizations. It occurs when individuals pursue opportunities and do new things, deviating from the usual. The distinction between intrapreneurship and conventional entrepreneurship is supported by the intensity of the judgment used and, in part, by their control over resources. The observation, appreciation, description, and explanation of intrapreneurship are the reasons for conceptual discussions within the framework of current managerial theories related to productive activities of different dimensions and complexity. However, there is a field of exploration oriented to identify, describe, and evaluate intrapreneurship within organizations providing services such as health care, whether in the public or private. This article aims to specify the concept of intrapreneurship and discuss its relevance and possibilities in health care. The critical review identifies key factors in the promotion of intrapreneurship, such as identification with the organization, encouragement of personal dispositions, and the exercise of stimulating managerial leadership. In conclusion, promoting intrapreneurs can significantly improve healthcare services as it seeks new opportunities and introduces innovations to guarantee the right to health and patient safety, among other aspects. It also points out various fields in which entrepreneurship can be developed by members of the health team, especially nurses.