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Recurrent power outages in Panama have caused significant disruptions in the supply of drinking water, especially in urban areas such as San Miguelito. This study was conducted to assess the interdependence between electrical and water supply systems in Panama, and to propose solutions to mitigate the impact of power outages on water distribution. A systematic literature review was combined with the development of analysis matrices and a sensitivity analysis, evaluating the effectiveness of different interventions such as improving backup infrastructure and diversifying energy sources. It was found that the installation of emergency generators can significantly reduce the impact of power outages, while energy diversification offers a long-term solution. The proposed interventions improve the resilience of the water supply, but their implementation faces financial and regulatory challenges.