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This paper addressed the commercial purchase and sale contract, its generalities, main regulation in Panamanian Law and its importance for commercial Law. At first, the conceptual delimitation of the figure of the purchase and sale contract is made. Subsequently, an analysis of the current Panamanian regulations on the matter was carried out. Specifically the regulations of the Commercial Code. From the regulatory analysis, the main rules that govern this contract emerge, but also its delimitation, defining which types of sales are in the commercial sphere and which are in the civil sphere. The regulations were analyzed using the exegetical method of legal analysis. Among the conditions reached in the article, it is clear that there is enormous importance for commercial law in the study of the purchase and sale contract, since this is linked to the very origins and current development of commerce and therefore commercial law.