This article seeks to address the phenomenon of indigenous female migration in Panama, in particular, the feminization of indigenous migration, from a gender perspective. To this end, an analysis of the causes and consequences of indigenous women's mobility was conducted, which sought to identify the gender mobility that occurs in the lives of migrant women. We used an ethnographic methodology that we carry out in places of origin and destination of the main migratory flows of indigenous women. The stories and testimonies of indigenous migrant women reveal changes and continuities in their contexts and living conditions, that make it possible to draw a number of conclusions about gender mobility in relation to rural-urban migration.