Although Panama, due to its geographical position, has represented the obligatory step for many immigrants from all latitudes of the hemisphere, of which many have adopted this small Central American country as their new home. In recent years, phrases such as “the country where you live happier” or “one of the most prosperous economies in Latin America” fill Panamanians with great national pride. However, its distribution of wealth, the lack of a quality health and education system make the gap between the poorest and the richest even more noticeable. Among the most vulnerable populations are lesbians, gays, bisexuals and transgenders, intersexuals, and queers (LGBTIQ +), as they have a long history of invisibility. LGBTIQ + groups have been victims of both verbal and physical oppression by government authorities and religious groups. Therefore homophobia has always been accepted as normal and institutionalized. In this essay, the author uses the epistemology of the transnational butterfly from his sexilio to chronologically document the history of homosexuality in Panama, from a historical-social perspective, starting with European colonization, passing through the American presence to the present.