The COVID-19 pandemic has had an unprecedented impact on global public health, not only due to its physical effects but also because of the emotional and psychological consequences it triggered in various population groups. Pregnant women represent a particularly vulnerable sector, as they undergo a biological and emotional process that inherently involves significant adaptation demands. In this regard, this study was conducted to examine how the health crisis influenced their stress levels and psychological well-being. The objective of the study was to analyze the impact of COVID-19 on the stress levels of pregnant women receiving care at Hospital Santo Tomás between August and October 2020. A quantitative, descriptive, non-experimental, and cross-sectional design was employed, with a sample of 29 women aged 25 to 30 with healthy pregnancies. Data collection was carried out through a diagnostic questionnaire administered virtually via Google Forms, which allowed information to be obtained under conditions of social distancing and health restrictions. The results demonstrated that the pandemic significantly contributed to increased stress in the study population. All participants (100%) reported experiencing anxiety during pregnancy, while 28% expressed feeling unable to cope with the possibility of a COVID-19 infection. These findings highlight the importance of addressing the psychological dimension of prenatal care, as stress and anxiety can affect not only the mother’s health but also fetal development and family dynamics. It was concluded that there is a need to implement specific psychological support strategies for pregnant women in the context of health crises, in order to reduce anxiety levels and strengthen emotional resources during the gestation process.