Introduction: Dental biofilm is a thin, viscous layer composed of proteins, salivary components, gingival fluid, bacterial debris, host tissue cells, lipids, nucleic acids, and carbohydrates, and colonized by bacteria. It is bacterial biofilm, associated with periodontal disease, dental caries, peri-implantitis, root canal infection, and complications of potentially fatal systemic diseases [1, 2]. Biofilm affects periodontal tissues and, due to its potential role in oral disease, stimulates the search for therapeutic treatments. Objective: to provide relevant information that consolidates aspects of interest in periodontal therapy.
Methodology: A narrative literature review was conducted of original research and reviews published in PubMed, Scielo, Science Direct, MedLine, Elsevier, Springer, Redalyc, dissemination portals (Dialnet), repositories, and degree theses from 2005 to 2024.
Results: 85 articles were evaluated and 40 were selected according to inclusion criteria.
Conclusion: There is scientific interest in the use of various therapies with effects on dental biofilm and the search to prevent, control, and treat periodontal disease. Therapeutic evidence shows beneficial findings that favor the process of controlling dental biofilm and periodontal disease through different innovative approaches, identifying the bacterial agent to avoid the inappropriate use of antibiotics and applying joint therapies. The relevant information highlights the need to continue research that demonstrates substantial efficacy. Although different therapeutic techniques aimed at the same objective have been achieved with positive results, they are not comparable due to variability.
