Elevación extrema de CA-125 en un tumor seroso limítrofe de ovario: presentación de un caso

Jorge E. Lasso de la Vega Z.; Khadija Faruk Ravat Tarajiya

doi:10.48204/medica.v54n3.a9101

Submitted December 27, 2025

Published 2025-12-31

Casos de interés quirúrgico

Vol. 54 No. 3 (2025): Revista médica de Panamá

Extreme elevation of CA-125 in a borderline serous ovarian tumor: case report

Jorge E. Lasso de la Vega Z.⁺⁻
Khadija Faruk Ravat Tarajiya ⁺⁻

DOI https://doi.org/10.48204/medica.v54n3.a9101

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DOI: 10.48204/medica.v54n3.a9101

Published: 2025-12-31

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Lasso de la Vega Z., J. E., & Ravat Tarajiya , K. F. (2025). Extreme elevation of CA-125 in a borderline serous ovarian tumor: case report. Revista médica De Panamá, 54(3), 65–70. https://doi.org/10.48204/medica.v54n3.a9101

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

We present a case of an abdominopelvic mass and markedly elevated serum CA-125 levels, leading to a high suspicion of ovarian cancer. Surgery was performed, and histopathological examination revealed a borderline serous tumor of the ovary. During follow-up, CA-125 levels gradually decreased to normal levels.

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References

. Medina-Villaseñor EA, Quezada-Adame I, Oliver-Parra PA, Aboites-Lucero JL, Neyra-Ortíz E, Pérez-Castro JA, et al. Tumor pélvico asociado a incremento del CA125 por neoplasia benigna. Presentación de un caso resuelto por vía laparoscópica. Gac Mex Oncol [Internet]. 2011;10(5):311–8. Available from: https://www.elsevier.es/es-revista-gaceta-mexicana-oncologia-305-articulo-tumor-pelvico-asociado-incremento-del-X1665920111894333
. Neogi SS, Srivastava LM. Elevated tumour marker CA125: Interpretations in clinical practice. Curr Med Res Pract [Internet]. 2014 Sep 1 [cited 2025 May 22];4(5):214–8. Available from: https://www.sciencedirect.com/science/article/abs/pii/S2352081714001408
. Tolman CJ, Vaid T, Schreuder HER. Extremely elevated CA-125 in benign ovarian disease due to stretch of the peritoneum. BMJ Case Rep [Internet]. 2012 [cited 2025 May 22];2012:bcr2012006664. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4543764/
. Rana F, Mishra M, Saha K, Narayan R. Borderline serous ovarian neoplasm: case report of a diagnostic challenge in intraoperative frozen sections. Case Reports Women’s Heal [Internet]. 2020 Jul 1 [cited 2025 May 26];27:e00219. Available from: https://www.sciencedirect.com/science/article/pii/S2214911220300497
. Pruebas para el cáncer de ovario | American Cancer Society [Internet]. [cited 2025 May 26]. Available from: https://www.cancer.org/es/cancer/tipos/cancer-de-ovario/deteccion-diagnostico-clasificacion-por-etapas/como-se-diagnostica.html
. Ginecología Tumor epitelial limítrofe (borderline) del ovario: estudio de 33 casos | Progresos de Obstetricia y Ginecología [Internet]. [cited 2025 May 26]. Available from: https://www.elsevier.es/es-revista-progresos-obstetricia-ginecologia-151-articulo-ginecologia-tumor-epitelial-limitrofe-borderline-ovario-estudio-13009652
. Tratamiento de los tumores limítrofes de ovario (PDQ®) [Internet]. [cited 2025 May 26]. Available from: https://www.cancer.gov/espanol/tipos/ovario/pro/tratamiento-tumores-limitrofes-ovario-pdq#_277_toc
. Abascal-Saiz A, Sotillo-Mallo L, De Santiago J, Zapardiel I. Management of borderline ovarian tumours: A comprehensive review of the literature. Ecancermedicalscience. 2014 Feb 17;8(1).
. Momenimovahed Z, Mazidimoradi A, Allahqoli L, Salehiniya H. The Role of CA- 125 in the Management of Ovarian Cancer?: A Systematic Review. 2025;1–10. Available from: https://pubmed.ncbi.nlm.nih.gov/40067023/
. Moore RG, Miller MC, Steinhoff MM, Skates SJ, Lu KH, Lambert-Messerlian G, et al. Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders. Am J Obstet Gynecol [Internet]. 2012 [cited 2025 May 22];206(4):351.e1-351.e8. Available from: https://pubmed.ncbi.nlm.nih.gov/22284961/
. Waluyo ST, Tjokroprawiro BA. The clinicopathological characteristics of borderline ovarian tumors at Dr. Soetomo Hospital, Surabaya: a single center study. Bali Med J [Internet]. 2023 Feb 4 [cited 2025 May 26];12(1):615–20. Available from: https://www.balimedicaljournal.ejournals.ca/index.php/bmj/article/view/3983

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[1] . Medina-Villaseñor EA, Quezada-Adame I, Oliver-Parra PA, Aboites-Lucero JL, Neyra-Ortíz E, Pérez-Castro JA, et al. Tumor pélvico asociado a incremento del CA125 por neoplasia benigna. Presentación de un caso resuelto por vía laparoscópica. Gac Mex Oncol [Internet]. 2011;10(5):311–8. Available from: https://www.elsevier.es/es-revista-gaceta-mexicana-oncologia-305-articulo-tumor-pelvico-asociado-incremento-del-X1665920111894333

[2] . Neogi SS, Srivastava LM. Elevated tumour marker CA125: Interpretations in clinical practice. Curr Med Res Pract [Internet]. 2014 Sep 1 [cited 2025 May 22];4(5):214–8. Available from: https://www.sciencedirect.com/science/article/abs/pii/S2352081714001408

[3] . Tolman CJ, Vaid T, Schreuder HER. Extremely elevated CA-125 in benign ovarian disease due to stretch of the peritoneum. BMJ Case Rep [Internet]. 2012 [cited 2025 May 22];2012:bcr2012006664. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4543764/

[4] . Rana F, Mishra M, Saha K, Narayan R. Borderline serous ovarian neoplasm: case report of a diagnostic challenge in intraoperative frozen sections. Case Reports Women’s Heal [Internet]. 2020 Jul 1 [cited 2025 May 26];27:e00219. Available from: https://www.sciencedirect.com/science/article/pii/S2214911220300497

[5] . Pruebas para el cáncer de ovario | American Cancer Society [Internet]. [cited 2025 May 26]. Available from: https://www.cancer.org/es/cancer/tipos/cancer-de-ovario/deteccion-diagnostico-clasificacion-por-etapas/como-se-diagnostica.html

[6] . Ginecología Tumor epitelial limítrofe (borderline) del ovario: estudio de 33 casos | Progresos de Obstetricia y Ginecología [Internet]. [cited 2025 May 26]. Available from: https://www.elsevier.es/es-revista-progresos-obstetricia-ginecologia-151-articulo-ginecologia-tumor-epitelial-limitrofe-borderline-ovario-estudio-13009652

[7] . Tratamiento de los tumores limítrofes de ovario (PDQ®) [Internet]. [cited 2025 May 26]. Available from: https://www.cancer.gov/espanol/tipos/ovario/pro/tratamiento-tumores-limitrofes-ovario-pdq#_277_toc

[8] . Abascal-Saiz A, Sotillo-Mallo L, De Santiago J, Zapardiel I. Management of borderline ovarian tumours: A comprehensive review of the literature. Ecancermedicalscience. 2014 Feb 17;8(1).

[9] . Momenimovahed Z, Mazidimoradi A, Allahqoli L, Salehiniya H. The Role of CA- 125 in the Management of Ovarian Cancer?: A Systematic Review. 2025;1–10. Available from: https://pubmed.ncbi.nlm.nih.gov/40067023/

[10] . Moore RG, Miller MC, Steinhoff MM, Skates SJ, Lu KH, Lambert-Messerlian G, et al. Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders. Am J Obstet Gynecol [Internet]. 2012 [cited 2025 May 22];206(4):351.e1-351.e8. Available from: https://pubmed.ncbi.nlm.nih.gov/22284961/

[11] . Waluyo ST, Tjokroprawiro BA. The clinicopathological characteristics of borderline ovarian tumors at Dr. Soetomo Hospital, Surabaya: a single center study. Bali Med J [Internet]. 2023 Feb 4 [cited 2025 May 26];12(1):615–20. Available from: https://www.balimedicaljournal.ejournals.ca/index.php/bmj/article/view/3983

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