REACTANTES DE FASE AGUDA Y SU IMPACTO EN EL ESTADO NUTRICIONAL

Jeanid Guillén; Michael A. Hawkins; Boska E. Mislov; Vanessa M. Flores

Enviado agosto 22, 2024

Publicado 2026-04-06

Artículos de Investigación

Vol. 14 Núm. 1 (2001): Revista Médico Científica

REACTANTES DE FASE AGUDA Y SU IMPACTO EN EL ESTADO NUTRICIONAL

Jeanid Guillén⁺⁻
Michael A. Hawkins⁺⁻
Boska E. Mislov⁺⁻
Vanessa M. Flores⁺⁻

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DOI: ND

Publicado: 2026-04-06

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.

Resumen

La respuesta de fase aguda es aquella que se desencadena debido a la presencia de daño tisular, infección o inflamación en nuestro organismo. Dentro de esta respuesta, participan las proteínas de fase aguda para llegar a la restauración de la homeostasis. Los principales mediadores de esta respuesta son las citoquinas. Definiremos el concepto, clasificación, síntesis, regulación y función de los reactantes de fase aguda; desarrollaremos sus efectos sobre el metabolismo de los carbohidratos, lípidos, proteínas y minerales; y describiremos sus efectos inmunológicos y endocrinos. Además, la relación de los reactantes de fase aguda con el estado nutricional y la utilidad clínica de los mismos.

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Castillo C, Lagrutta F. Efecto de las infecciones sobre la nutrición y el metabolismo. Aev Chil Pediatr 1988; 59(5):339-44.
Sáez-L1orens X, Lagrutta F.The acute phase host reaction during bacterial infection and its clinical impact in children. Pediatr Infect Dis J 1993; 12:83-7.
Stephensen CB: Burden of infection on growth failure. J Nutr 1999; 129:534S-8S.
Gabay C, Kushner 1. Acute phase proteins and other systemic responses to inflammation. N Engl J
Med 1999; 340(6):448~54.
Mazuki JE, Tolman K, Shapiro MJ. Effects of cytokine antagonists on the hepatic acute-phase response. J Surg Aes 1997; 68(2):161-9.
Aamadori G, Christ B. Cyotkines and the hepatic acute-phase response. Semin Liver Dis <1999; 19(2):141·555.
Wigmore SJ, Fearon KCH, Maingay JP, Lai PBS, Aoss JA. Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes. Am J Physiol1997; 66:1-11.
Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87:2095-147.
Jakab L, Kalabay L. The acute phase reaction syndrome: the acute phase reactants. Acta Microbiollmmunol Hung 1998; 45(3-4):409-18.
Stites DP, Parslow TG, Terr Al. Inmunología Básica y Clínica En: Oppenheim JJ, Auscetti FW, Faltynek C (eds). Citocinas. 8va edición. México D.F. El Manual Moderno, S.A. 1996: 135-145.
Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: antiinflamatory ando immunosuppressive mediators. Immnunol Today 1997; 18(9):428-32.
Lyomi S, Tamion F, Petit J, et al. Induction and modulation of acute-phase response by protein
malnutrition rats: comparative ef1ect of systemic and localized inflammation on interleukin-6 and
acute-phase protein synthesis. J Nutr 1998; 128(2): 166·74.
Urieli-Shoval S. Expression and function of serum amyloid A, a major acute phase protein, in normal
and disease states. Curr Opin Hematol 2000; 7(1):64-69.
Suffredini AF, Fantuzzi G, Badolato A. Oppenheim JJ, O'Grady NP. New insights into the biology of the
acute phase response. J Clin Immunol 1999; 19(4):203-14.
Fleck A. Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc
Nutr Soc 1989: 347·54.
Weiss G, Bogdan C, Hentze MW. Pathways for the regulation of macrophages iron metabolism by
antiinflamatory cytokines IL-4 and IL-13. J Immunol 1997; 158:420-5.
Dinarello CA. Cytokines as endogenous pyrogens En: Mackowiac ~A (ed). Fever Basic Mechanisms
and managements. 2da edición. Philadelphia. Lippincott-Aaven 1997: 87-116.
Tai H, Miyaura C, Pilbeam CC, et al. Transcriptional induction of cyclooxygenase 2 in
osteoblasts is ¡nvolved in interleukin induced osteoclasts formation. Endocrynology 1997;
:2372-9.
Moldawer LL, Copeland EM 111. Proinflamatory cytokines, nutritional support, and the cachexia
syndrom: interactions and therapeutic options. Cancer 1997; 79: 1828-39.
Hardarottir 1, Grunfeld C, Feingold KA. Effects of endotoxin and cytokines on lipid metabolism. Curr
Opin Lipidol 1994; 5:207-15.
Barton BE. IL-6: Insights into novel biological activities. CHn Immunol Immunopathol 1997; 85:16-20
Rahman M. Mahalanabis D, Alvarez JO, et al. Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with A. J Nutr 1996; 126:628-33.
Brown KH, Stallings RY, Kanashiro HC, L6pez de Romana G, Black RE. Effects of common iIIness on infants' energy intakes from breast milk and other foods during longitudinal community-based studies in Juascar (Lima), Perú. Am J Clin Nutr 1990; 52:1005-13.

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[1] Castillo C, Lagrutta F. Efecto de las infecciones sobre la nutrición y el metabolismo. Aev Chil Pediatr 1988; 59(5):339-44.

[2] Sáez-L1orens X, Lagrutta F.The acute phase host reaction during bacterial infection and its clinical impact in children. Pediatr Infect Dis J 1993; 12:83-7.

[3] Stephensen CB: Burden of infection on growth failure. J Nutr 1999; 129:534S-8S.

[4] Gabay C, Kushner 1. Acute phase proteins and other systemic responses to inflammation. N Engl J

[5] Med 1999; 340(6):448~54.

[6] Mazuki JE, Tolman K, Shapiro MJ. Effects of cytokine antagonists on the hepatic acute-phase response. J Surg Aes 1997; 68(2):161-9.

[7] Aamadori G, Christ B. Cyotkines and the hepatic acute-phase response. Semin Liver Dis <1999; 19(2):141·555.

[8] Wigmore SJ, Fearon KCH, Maingay JP, Lai PBS, Aoss JA. Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes. Am J Physiol1997; 66:1-11.

[9] Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87:2095-147.

[10] Jakab L, Kalabay L. The acute phase reaction syndrome: the acute phase reactants. Acta Microbiollmmunol Hung 1998; 45(3-4):409-18.

[11] Stites DP, Parslow TG, Terr Al. Inmunología Básica y Clínica En: Oppenheim JJ, Auscetti FW, Faltynek C (eds). Citocinas. 8va edición. México D.F. El Manual Moderno, S.A. 1996: 135-145.

[12] Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: antiinflamatory ando immunosuppressive mediators. Immnunol Today 1997; 18(9):428-32.

[13] Lyomi S, Tamion F, Petit J, et al. Induction and modulation of acute-phase response by protein

[14] malnutrition rats: comparative ef1ect of systemic and localized inflammation on interleukin-6 and

[15] acute-phase protein synthesis. J Nutr 1998; 128(2): 166·74.

[16] Urieli-Shoval S. Expression and function of serum amyloid A, a major acute phase protein, in normal

[17] and disease states. Curr Opin Hematol 2000; 7(1):64-69.

[18] Suffredini AF, Fantuzzi G, Badolato A. Oppenheim JJ, O'Grady NP. New insights into the biology of the

[19] acute phase response. J Clin Immunol 1999; 19(4):203-14.

[20] Fleck A. Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc

[21] Nutr Soc 1989: 347·54.

[22] Weiss G, Bogdan C, Hentze MW. Pathways for the regulation of macrophages iron metabolism by

[23] antiinflamatory cytokines IL-4 and IL-13. J Immunol 1997; 158:420-5.

[24] Dinarello CA. Cytokines as endogenous pyrogens En: Mackowiac ~A (ed). Fever Basic Mechanisms

[25] and managements. 2da edición. Philadelphia. Lippincott-Aaven 1997: 87-116.

[26] Tai H, Miyaura C, Pilbeam CC, et al. Transcriptional induction of cyclooxygenase 2 in

[27] osteoblasts is ¡nvolved in interleukin induced osteoclasts formation. Endocrynology 1997;

[28] :2372-9.

[29] Moldawer LL, Copeland EM 111. Proinflamatory cytokines, nutritional support, and the cachexia

[30] syndrom: interactions and therapeutic options. Cancer 1997; 79: 1828-39.

[31] Hardarottir 1, Grunfeld C, Feingold KA. Effects of endotoxin and cytokines on lipid metabolism. Curr

[32] Opin Lipidol 1994; 5:207-15.

[33] Barton BE. IL-6: Insights into novel biological activities. CHn Immunol Immunopathol 1997; 85:16-20

[34] Rahman M. Mahalanabis D, Alvarez JO, et al. Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with A. J Nutr 1996; 126:628-33.

[35] Brown KH, Stallings RY, Kanashiro HC, L6pez de Romana G, Black RE. Effects of common iIIness on infants' energy intakes from breast milk and other foods during longitudinal community-based studies in Juascar (Lima), Perú. Am J Clin Nutr 1990; 52:1005-13.

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