REACTANTES DE FASE AGUDA Y SU IMPACTO EN EL ESTADO NUTRICIONAL

Jeanid Guillén; Michael A. Hawkins; Boska E. Mislov; Vanessa M. Flores

Submitted August 22, 2024

Published 2026-04-06

Artículos de Investigación

Vol. 14 No. 1 (2001): Revista Médico Científica

REACTANTES DE FASE AGUDA Y SU IMPACTO EN EL ESTADO NUTRICIONAL

Jeanid Guillén⁺⁻
Michael A. Hawkins⁺⁻
Boska E. Mislov⁺⁻
Vanessa M. Flores⁺⁻

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DOI: ND

Published: 2026-04-06

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1.

Guillén J, Hawkins MA, Mislov BE, Flores VM. REACTANTES DE FASE AGUDA Y SU IMPACTO EN EL ESTADO NUTRICIONAL . rmc [Internet]. 2026 Apr. 6 [cited 2026 Oct. 18];14(1):12-8. Available from: https://revistas.up.ac.pa/index.php/revistamedicocientifica/article/view/5605

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

The acute phase response develops from tissue injury, infection or inflammation. Within this response, acute phase proteins are involved in the restoration of homeostasis. Cytokines are the main mediators of this response. We'lI define the concept, classification, synthesis, regulation and function of acute phase proteins. We'lI review its effects on carbohydrates, lipids, proteins and mineral metabolism and we'lI describe its immunological and endocrine effects. And also, the relationship between acute phase proteins and nutritional state and the clinic utility.

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References

Castillo C, Lagrutta F. Efecto de las infecciones sobre la nutrición y el metabolismo. Aev Chil Pediatr 1988; 59(5):339-44.
Sáez-L1orens X, Lagrutta F.The acute phase host reaction during bacterial infection and its clinical impact in children. Pediatr Infect Dis J 1993; 12:83-7.
Stephensen CB: Burden of infection on growth failure. J Nutr 1999; 129:534S-8S.
Gabay C, Kushner 1. Acute phase proteins and other systemic responses to inflammation. N Engl J
Med 1999; 340(6):448~54.
Mazuki JE, Tolman K, Shapiro MJ. Effects of cytokine antagonists on the hepatic acute-phase response. J Surg Aes 1997; 68(2):161-9.
Aamadori G, Christ B. Cyotkines and the hepatic acute-phase response. Semin Liver Dis <1999; 19(2):141·555.
Wigmore SJ, Fearon KCH, Maingay JP, Lai PBS, Aoss JA. Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes. Am J Physiol1997; 66:1-11.
Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87:2095-147.
Jakab L, Kalabay L. The acute phase reaction syndrome: the acute phase reactants. Acta Microbiollmmunol Hung 1998; 45(3-4):409-18.
Stites DP, Parslow TG, Terr Al. Inmunología Básica y Clínica En: Oppenheim JJ, Auscetti FW, Faltynek C (eds). Citocinas. 8va edición. México D.F. El Manual Moderno, S.A. 1996: 135-145.
Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: antiinflamatory ando immunosuppressive mediators. Immnunol Today 1997; 18(9):428-32.
Lyomi S, Tamion F, Petit J, et al. Induction and modulation of acute-phase response by protein
malnutrition rats: comparative ef1ect of systemic and localized inflammation on interleukin-6 and
acute-phase protein synthesis. J Nutr 1998; 128(2): 166·74.
Urieli-Shoval S. Expression and function of serum amyloid A, a major acute phase protein, in normal
and disease states. Curr Opin Hematol 2000; 7(1):64-69.
Suffredini AF, Fantuzzi G, Badolato A. Oppenheim JJ, O'Grady NP. New insights into the biology of the
acute phase response. J Clin Immunol 1999; 19(4):203-14.
Fleck A. Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc
Nutr Soc 1989: 347·54.
Weiss G, Bogdan C, Hentze MW. Pathways for the regulation of macrophages iron metabolism by
antiinflamatory cytokines IL-4 and IL-13. J Immunol 1997; 158:420-5.
Dinarello CA. Cytokines as endogenous pyrogens En: Mackowiac ~A (ed). Fever Basic Mechanisms
and managements. 2da edición. Philadelphia. Lippincott-Aaven 1997: 87-116.
Tai H, Miyaura C, Pilbeam CC, et al. Transcriptional induction of cyclooxygenase 2 in
osteoblasts is ¡nvolved in interleukin induced osteoclasts formation. Endocrynology 1997;
:2372-9.
Moldawer LL, Copeland EM 111. Proinflamatory cytokines, nutritional support, and the cachexia
syndrom: interactions and therapeutic options. Cancer 1997; 79: 1828-39.
Hardarottir 1, Grunfeld C, Feingold KA. Effects of endotoxin and cytokines on lipid metabolism. Curr
Opin Lipidol 1994; 5:207-15.
Barton BE. IL-6: Insights into novel biological activities. CHn Immunol Immunopathol 1997; 85:16-20
Rahman M. Mahalanabis D, Alvarez JO, et al. Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with A. J Nutr 1996; 126:628-33.
Brown KH, Stallings RY, Kanashiro HC, L6pez de Romana G, Black RE. Effects of common iIIness on infants' energy intakes from breast milk and other foods during longitudinal community-based studies in Juascar (Lima), Perú. Am J Clin Nutr 1990; 52:1005-13.

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[1] Castillo C, Lagrutta F. Efecto de las infecciones sobre la nutrición y el metabolismo. Aev Chil Pediatr 1988; 59(5):339-44.

[2] Sáez-L1orens X, Lagrutta F.The acute phase host reaction during bacterial infection and its clinical impact in children. Pediatr Infect Dis J 1993; 12:83-7.

[3] Stephensen CB: Burden of infection on growth failure. J Nutr 1999; 129:534S-8S.

[4] Gabay C, Kushner 1. Acute phase proteins and other systemic responses to inflammation. N Engl J

[5] Med 1999; 340(6):448~54.

[6] Mazuki JE, Tolman K, Shapiro MJ. Effects of cytokine antagonists on the hepatic acute-phase response. J Surg Aes 1997; 68(2):161-9.

[7] Aamadori G, Christ B. Cyotkines and the hepatic acute-phase response. Semin Liver Dis <1999; 19(2):141·555.

[8] Wigmore SJ, Fearon KCH, Maingay JP, Lai PBS, Aoss JA. Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes. Am J Physiol1997; 66:1-11.

[9] Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87:2095-147.

[10] Jakab L, Kalabay L. The acute phase reaction syndrome: the acute phase reactants. Acta Microbiollmmunol Hung 1998; 45(3-4):409-18.

[11] Stites DP, Parslow TG, Terr Al. Inmunología Básica y Clínica En: Oppenheim JJ, Auscetti FW, Faltynek C (eds). Citocinas. 8va edición. México D.F. El Manual Moderno, S.A. 1996: 135-145.

[12] Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: antiinflamatory ando immunosuppressive mediators. Immnunol Today 1997; 18(9):428-32.

[13] Lyomi S, Tamion F, Petit J, et al. Induction and modulation of acute-phase response by protein

[14] malnutrition rats: comparative ef1ect of systemic and localized inflammation on interleukin-6 and

[15] acute-phase protein synthesis. J Nutr 1998; 128(2): 166·74.

[16] Urieli-Shoval S. Expression and function of serum amyloid A, a major acute phase protein, in normal

[17] and disease states. Curr Opin Hematol 2000; 7(1):64-69.

[18] Suffredini AF, Fantuzzi G, Badolato A. Oppenheim JJ, O'Grady NP. New insights into the biology of the

[19] acute phase response. J Clin Immunol 1999; 19(4):203-14.

[20] Fleck A. Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc

[21] Nutr Soc 1989: 347·54.

[22] Weiss G, Bogdan C, Hentze MW. Pathways for the regulation of macrophages iron metabolism by

[23] antiinflamatory cytokines IL-4 and IL-13. J Immunol 1997; 158:420-5.

[24] Dinarello CA. Cytokines as endogenous pyrogens En: Mackowiac ~A (ed). Fever Basic Mechanisms

[25] and managements. 2da edición. Philadelphia. Lippincott-Aaven 1997: 87-116.

[26] Tai H, Miyaura C, Pilbeam CC, et al. Transcriptional induction of cyclooxygenase 2 in

[27] osteoblasts is ¡nvolved in interleukin induced osteoclasts formation. Endocrynology 1997;

[28] :2372-9.

[29] Moldawer LL, Copeland EM 111. Proinflamatory cytokines, nutritional support, and the cachexia

[30] syndrom: interactions and therapeutic options. Cancer 1997; 79: 1828-39.

[31] Hardarottir 1, Grunfeld C, Feingold KA. Effects of endotoxin and cytokines on lipid metabolism. Curr

[32] Opin Lipidol 1994; 5:207-15.

[33] Barton BE. IL-6: Insights into novel biological activities. CHn Immunol Immunopathol 1997; 85:16-20

[34] Rahman M. Mahalanabis D, Alvarez JO, et al. Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with A. J Nutr 1996; 126:628-33.

[35] Brown KH, Stallings RY, Kanashiro HC, L6pez de Romana G, Black RE. Effects of common iIIness on infants' energy intakes from breast milk and other foods during longitudinal community-based studies in Juascar (Lima), Perú. Am J Clin Nutr 1990; 52:1005-13.

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