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Introduction. Ulceropeptic disease is a very common clinical problem. In developed countries. the risk of acquiring this disease throughout life is 5 - 10 %. NSAID'~ are the most important risk factors for the development of bleeding.
Methodology. A not matched retrospective case - control study was made with a sample of 214 patients, who consulted the Gastroenterology Service of the Complejo Hospitalario Metropolitano, between January 1999 and March 2001, and who had a previous diagnosis of gastric or duodenal ulcer, with or without a history of upper GI bleeding. Data was obtained by inquest and analyzed to get the values of X2 and OR (confusing factors were adjusted according to Mantel - Haenszel's method) with their corresponding confidence interval.
Results. Patients with ulceropeptic disease that used NSAIDs had a risk 2.43 times higher of upper gastrointestinal bleeding than patients who did not used them (CI 95 % 1.34 - 4.41). When studying age groups, in the group 51 - 75 years we found an OR =2.74 (CI 95 % 1.23 - 6.13) and in the group over 75 years the OR =6.60 (CI 95 % 2.01 - 21.67).
Discussion. As in the reviewed Iiterature, we found that NSAIDs are a risk factor for the appearance of upper GI bleeding. We also found that age is an important risk factor, observing that as age increases so does the OA.
