ENFERMEDAD DE BEHCET. PRESENTACIÓN DE UN CASO

Lorena Noriega; Digna Díaz

Submitted October 15, 2024

Published 2026-04-06

Artículos de Investigación

Vol. 17 No. 1 (2004): Revista Médico Científica

BEHCET'S DISEASE. A CASE PRESENTATION

Lorena Noriega⁺⁻
Digna Díaz⁺⁻

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Published: 2026-04-06

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Abstract

A 32 year old woman comes for medical attention because of two months with symmetrical migratory arthritis, fever, red eyes, photophobia and blurred vision. Lately, she presented skin lesions on her legs and finally with ulcers of her oral mucosa and tongue, dysphagia and hoarse voice.

On physical examination it was found vaginal ulcers and bilateral uveitis, features that make you think on Behcet disease, also known as "the disease of the silk route" because of its high frequency on silk producing countries as Turkey; although is not that frequent in our area, it has to be included as a differential diagnosis because its diagnostic criteria are easily clinically determined.

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References

Farreras R. Medicina Interna. Edición CD-ROM 13. Madrid, España. 2000.
Iseelbacher AB, Braunwald E, Wilson J, Martin J, Fauci A, Kasper D. Principios de Medicina Interna. Madrid: Ed McGraw Hill-Interamericana; 1994.
Short CL, Bauer W, Reynolds WE. Rheumatoid arthritis. Cambridge: Harvard University Press; 1957.
Catterall RD. Clinical aspects of Reiter’s disease. Br J Rheumatol. 1983; 22 Suppl 2:151-5.
Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Calin A. A new approach to defining disease status in ankylosing spondylitis; the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994; 21: 2286-91.
Figueroa F, Herera G, Andreu J. Manual de enfermedades reumáticas. España: Editorial Clamades, S.A.; 1996.
Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 331:1272-85.
Lehman SS. Long-term ocular complication of Steven-Johnson syndrome. Clin Pediatr (Phila) 1999; 38:425-7.
Rodriguez M, Siva A, Cross SA, O'Brien PC, Kurland LT. Optic neuritis: a population-based study in Olmsted County, Minnesota. Neurology 1995; 45:2144-50.
Stern BJ, Krumholz A, Johns C, Scott E, Nissim J. Sarcoidosis and its neurological manifestations. Arch Neurol 1985; 42:909-11.
Zouboulis CC, Kötter I, Djawari D, Kirch W, Kohl PK, Ochsendorf FR, et al. Epidemiological features of Adamantiades-Behcet’s disease in Germany and in Europe. Yonsei Med J 1997; 38:411-22.
Nakae K, Masaki F, Hashimoto T, Inaba G, Mochizuki M, Sakane T. Recent epidemiological features of Behcet’s disease in Japan. In: Weschler B, Godeau B, eds. Behcet’s disease. Amsterdam: Excerpta Medica; 1993. p. 145-51.
Plotkin GR, Calabro JJ, O'Duffy JD, eds. Behcet’s disease: a contemporary synopsis. New York: Futura; 1998.
Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa M. Close association of HLA-B51 with Behcet’s disease. Arch Ophthalmol 1982; 100:1455-8.
Lehner T. The role of heat shock protein, microbial, and autoimmune agents in the etiology of Behcet’s disease. Int Rev Immunol 1997; 14:21-32.
Ehrlich GE. Vasculitis in Behcet’s disease. Int Rev Immunol 1997; 14:81-8.
Yamashita N, Kaneoka H, Kaneko S, Takeno M, Oneda K, Koizumi H, et al. Role of gammadelta T lymphocytes in the development of Behcet’s disease. Clin Exp Immunol 1997; 107:241-7.
Criteria for diagnosis of Behcet’s disease. International Study Group for Behcet’s Disease. Lancet 1990; 335:1078-80.
Sakane T, Takeno M, Suzuki G, Inaba G. Current concepts: Behcet’s disease. N Engl J Med 1999; 341:1284-91.
Nussenblatt RB, Palestine AG, Chan CC, et al. Effectiveness of cyclosporine therapy for Behcet’s disease. Arthritis Rheum 1985; 24:672-5

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[1] Farreras R. Medicina Interna. Edición CD-ROM 13. Madrid, España. 2000.

[2] Iseelbacher AB, Braunwald E, Wilson J, Martin J, Fauci A, Kasper D. Principios de Medicina Interna. Madrid: Ed McGraw Hill-Interamericana; 1994.

[3] Short CL, Bauer W, Reynolds WE. Rheumatoid arthritis. Cambridge: Harvard University Press; 1957.

[4] Catterall RD. Clinical aspects of Reiter’s disease. Br J Rheumatol. 1983; 22 Suppl 2:151-5.

[5] Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Calin A. A new approach to defining disease status in ankylosing spondylitis; the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994; 21: 2286-91.

[6] Figueroa F, Herera G, Andreu J. Manual de enfermedades reumáticas. España: Editorial Clamades, S.A.; 1996.

[7] Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 331:1272-85.

[8] Lehman SS. Long-term ocular complication of Steven-Johnson syndrome. Clin Pediatr (Phila) 1999; 38:425-7.

[9] Rodriguez M, Siva A, Cross SA, O'Brien PC, Kurland LT. Optic neuritis: a population-based study in Olmsted County, Minnesota. Neurology 1995; 45:2144-50.

[10] Stern BJ, Krumholz A, Johns C, Scott E, Nissim J. Sarcoidosis and its neurological manifestations. Arch Neurol 1985; 42:909-11.

[11] Zouboulis CC, Kötter I, Djawari D, Kirch W, Kohl PK, Ochsendorf FR, et al. Epidemiological features of Adamantiades-Behcet’s disease in Germany and in Europe. Yonsei Med J 1997; 38:411-22.

[12] Nakae K, Masaki F, Hashimoto T, Inaba G, Mochizuki M, Sakane T. Recent epidemiological features of Behcet’s disease in Japan. In: Weschler B, Godeau B, eds. Behcet’s disease. Amsterdam: Excerpta Medica; 1993. p. 145-51.

[13] Plotkin GR, Calabro JJ, O'Duffy JD, eds. Behcet’s disease: a contemporary synopsis. New York: Futura; 1998.

[14] Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa M. Close association of HLA-B51 with Behcet’s disease. Arch Ophthalmol 1982; 100:1455-8.

[15] Lehner T. The role of heat shock protein, microbial, and autoimmune agents in the etiology of Behcet’s disease. Int Rev Immunol 1997; 14:21-32.

[16] Ehrlich GE. Vasculitis in Behcet’s disease. Int Rev Immunol 1997; 14:81-8.

[17] Yamashita N, Kaneoka H, Kaneko S, Takeno M, Oneda K, Koizumi H, et al. Role of gammadelta T lymphocytes in the development of Behcet’s disease. Clin Exp Immunol 1997; 107:241-7.

[18] Criteria for diagnosis of Behcet’s disease. International Study Group for Behcet’s Disease. Lancet 1990; 335:1078-80.

[19] Sakane T, Takeno M, Suzuki G, Inaba G. Current concepts: Behcet’s disease. N Engl J Med 1999; 341:1284-91.

[20] Nussenblatt RB, Palestine AG, Chan CC, et al. Effectiveness of cyclosporine therapy for Behcet’s disease. Arthritis Rheum 1985; 24:672-5

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