PSORIASIS CONCEPTOS ACTUALES

Iván Cedeño B.; José M Rios Yuil

Submitted October 25, 2024

Published 2026-04-06

Artículos de Investigación

Vol. 18 No. 1 (2005): Revista Médico Científica

PSORIASIS: CURRENT CONCEPTS

Iván Cedeño B.⁺⁻
José M Rios Yuil⁺⁻

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Published: 2026-04-06

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Abstract

Psoriasis is a non-contagious chronic dermatosis, characterized by well-defined squamous-erythematous cutaneous lesions mainly located in the scalp, elbows, knees, sacral region, extension surface of the forearm that could affect large zones of the skin and exceptionally the face. It can also affect nails and joints. Psoriasis is a non-tumoral proliferation of genetically predisposed keratinocyte produced by physical agents (trauma, environmental changes, and heat), chemical agents (toxics, drugs), infections,: allergic and neuropsychic reactions. It can be classified in Type I and Type 1I psoriasis according to age, c1ínical evolution and genetic history, and there are also diverse clinical forms. Diagnose is done by clinical findings, methodic scaling and is confirmed by a biopsy. Important remissions can be achieved with a treatment adapted to each case and each evolutionary state ofthe disease. The duration ofthe remission period can't be predicted.

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References

Arenas R. Atlas de Dermatología. Tercera edición. México 2004. p.491-9.
Passeron T, Bahadoran P, Lacour JP, Ortonne JP. Psoriasis. Clinical cutaneous aspects. Presse Med. 1999 Jun 26;28(23):1246-50.
Delgado M, Quincha M, Méndez M. Valoración de la calidad de vida, mediante la aplicación del Test SF-36V2 en pacientes de la Fundación de Psoriasis de la ciudad de Quito. Dermatología Peruana 2003;13(3).
Honeyman J. Fisiopatología de la psoriasis. Rev Chilena Dermatol 2003;19(4):282-93.
Honeyman J. Aspectos fisiopatológicos de la psoriasis. En: Sánchez Millán I (Ed.): Psoriasis. Actualidades Médicas. Santiago, Chile, 1999, pp 21-96.
Honeyman J. Etiopatogenia de la psoriasis (1). Etiología. Piel 2000;15:103-17.
Honeyman J. Etiopatogenia de la psoriasis (2). Patogenia. Piel 2001;16(2):69-84.
Wilson CI, Dean D, Lane EB, Dawber RP, Leigh IM. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins. Br J Dermatol. 1994 Aug;131(2):191-200.
Karvonen SL, Korkiamaki T, Yla-Outinen H, et al. Psoriasis and altered calcium metabolism: downregulated capacitative calcium influx and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes. J Invest Dermatol. 2000 Apr;114(4):693-700.
Lavker RM. Heterogeneity in epidermal basal cell keratinocytes, morphological and funcional correlation. Science 1982;215:1239-41.
Choi J-H, O'Connor TP, Kang S, et al. Activation of ribosomal protein S6 kinase in psoriatic lesions and cultured human keratinocytes by epidermal growth factor receptor ligands. J Invest Dermatol 1997;108:98-102.
Elder JT, Nair RP, Guo SW, et al. The genetics of psoriasis. Arch Dermatol 1994;130(2):216-24.
Elder JT, Nair RP, Henseler T, Jenisch S, et al. The genetics of psoriasis 2001: the odyssey continues. Arch Dermatol. 2001 Nov;137(11):1447-54.
Enerback C, Enlund F, Inerot A, et al. S gene (corneodesmosin) diversity and its relationship to psoriasis; high content of csnp in the HLA-linked S gene. J Invest Dermatol 2000;114(6):1158-63.
Moles JP. Genes du développement. Définitions et apport en biologie cutanée. Ann Dermatol Venereol 1990;126:184-5.
Kadunce DP, Krueger GG. Pathogenesis of psoriasis. Dermatol Clin. 1995 Oct;13(4):723-37.
Henseler T. The genetics of psoriasis. J Am Acad Dermatol 1997;37:S1-S11.
Traupe H. The puzzling genetics of psoriasis. Clinics in Dermatol 1995;13:99-104.
Ortonne JP. Recent developments in the understanding of the pathogenesis of psoriasis. Br J Dermatol. 1999 Apr;140 Suppl 54:1-7.
García Pérez A. Dermatología clínica. Quinta edición. Salamanca, España. 1997. p.229, 238, 275-8, 280-1, 406, 541, 579.
Manzini M. Dermatología clínica. Segunda edición. Buenos Aires, Argentina 1985. p.120, 152, 395, 497, 504, 506-7.
Gatti C, Cabrera H. Dermatología de Gatti-Cardama. Décimosegunda edición. Buenos Aires, Argentina 2003. p.68, 72, 245, 247.
Chiaverini C, Desruelles F, Lacour JP, Ortonne JP. Psoriasis. Treatment. Presse Med. 1999 Jun 26;28(23):1266-73.

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[1] Arenas R. Atlas de Dermatología. Tercera edición. México 2004. p.491-9.

[2] Passeron T, Bahadoran P, Lacour JP, Ortonne JP. Psoriasis. Clinical cutaneous aspects. Presse Med. 1999 Jun 26;28(23):1246-50.

[3] Delgado M, Quincha M, Méndez M. Valoración de la calidad de vida, mediante la aplicación del Test SF-36V2 en pacientes de la Fundación de Psoriasis de la ciudad de Quito. Dermatología Peruana 2003;13(3).

[4] Honeyman J. Fisiopatología de la psoriasis. Rev Chilena Dermatol 2003;19(4):282-93.

[5] Honeyman J. Aspectos fisiopatológicos de la psoriasis. En: Sánchez Millán I (Ed.): Psoriasis. Actualidades Médicas. Santiago, Chile, 1999, pp 21-96.

[6] Honeyman J. Etiopatogenia de la psoriasis (1). Etiología. Piel 2000;15:103-17.

[7] Honeyman J. Etiopatogenia de la psoriasis (2). Patogenia. Piel 2001;16(2):69-84.

[8] Wilson CI, Dean D, Lane EB, Dawber RP, Leigh IM. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins. Br J Dermatol. 1994 Aug;131(2):191-200.

[9] Karvonen SL, Korkiamaki T, Yla-Outinen H, et al. Psoriasis and altered calcium metabolism: downregulated capacitative calcium influx and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes. J Invest Dermatol. 2000 Apr;114(4):693-700.

[10] Lavker RM. Heterogeneity in epidermal basal cell keratinocytes, morphological and funcional correlation. Science 1982;215:1239-41.

[11] Choi J-H, O'Connor TP, Kang S, et al. Activation of ribosomal protein S6 kinase in psoriatic lesions and cultured human keratinocytes by epidermal growth factor receptor ligands. J Invest Dermatol 1997;108:98-102.

[12] Elder JT, Nair RP, Guo SW, et al. The genetics of psoriasis. Arch Dermatol 1994;130(2):216-24.

[13] Elder JT, Nair RP, Henseler T, Jenisch S, et al. The genetics of psoriasis 2001: the odyssey continues. Arch Dermatol. 2001 Nov;137(11):1447-54.

[14] Enerback C, Enlund F, Inerot A, et al. S gene (corneodesmosin) diversity and its relationship to psoriasis; high content of csnp in the HLA-linked S gene. J Invest Dermatol 2000;114(6):1158-63.

[15] Moles JP. Genes du développement. Définitions et apport en biologie cutanée. Ann Dermatol Venereol 1990;126:184-5.

[16] Kadunce DP, Krueger GG. Pathogenesis of psoriasis. Dermatol Clin. 1995 Oct;13(4):723-37.

[17] Henseler T. The genetics of psoriasis. J Am Acad Dermatol 1997;37:S1-S11.

[18] Traupe H. The puzzling genetics of psoriasis. Clinics in Dermatol 1995;13:99-104.

[19] Ortonne JP. Recent developments in the understanding of the pathogenesis of psoriasis. Br J Dermatol. 1999 Apr;140 Suppl 54:1-7.

[20] García Pérez A. Dermatología clínica. Quinta edición. Salamanca, España. 1997. p.229, 238, 275-8, 280-1, 406, 541, 579.

[21] Manzini M. Dermatología clínica. Segunda edición. Buenos Aires, Argentina 1985. p.120, 152, 395, 497, 504, 506-7.

[22] Gatti C, Cabrera H. Dermatología de Gatti-Cardama. Décimosegunda edición. Buenos Aires, Argentina 2003. p.68, 72, 245, 247.

[23] Chiaverini C, Desruelles F, Lacour JP, Ortonne JP. Psoriasis. Treatment. Presse Med. 1999 Jun 26;28(23):1266-73.

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