CONSENSO DE USO DE VITAMINA D

Ramiro Da Silva LLibre; Juan D Barrios Matamoros; Luis Gorriz Añorbes; Diógenes Arjona Plano; Vielka Sanjour; Aldimarina López; Carmen Troya; Konstantinos Tserotas; Enrique José Mayo Di Bello

Submitted October 28, 2024

Published 2026-02-02

Artículos de Investigación

Vol. 32 (2019): Revista Médico Científica

CONSENSO DE USO DE VITAMINA D

Ramiro Da Silva LLibre⁺⁻
Juan D Barrios Matamoros⁺⁻
Luis Gorriz Añorbes⁺⁻
Diógenes Arjona Plano⁺⁻
Vielka Sanjour⁺⁻
Aldimarina López⁺⁻
Carmen Troya⁺⁻
Konstantinos Tserotas⁺⁻
Enrique José Mayo Di Bello⁺⁻

PDF (Español (España))

Citación:

DOI: ND

Published: 2026-02-02

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

La vitamina D ha sido motivo de muchos estudios y discusiones tratando de comprobar sus bondades y bene?cios, y hoy en día, es considerada una hormona por múltiples razones. En la última década hemos tenido cientos de publicaciones a favor y en contra de su uso en diferentes patologías. Esto ha traído como consecuencia que, en diferentes países, grupos de expertos en el tema se reúnan para revisar la literatura, sacar conclusiones y así orientar a los diferentes grupos médicos en el uso racional de la mal llamada vitamina D.Actualmente se le ha dado mucha importancia en diferentes campos. Desde las primeras publicaciones de su efecto sobre fracturas y caídas, pasando posteriormente por su papel en cáncer, riesgo cardiovascular e inmunología, hasta llegar al embarazo y feto.Por tal motivo en Panamá, un grupo de expertos, miembros del Consejo Panameño de Osteoporosis, decidimos realizar una revisión de la literatura de los últimos 15 años para llegar a conclusiones, que sean de utilidad a la comunidad médica y así poder tomar mejores decisiones. Se revisaron las bases de datos, PubMed, MEDLINE, Clinical Key, HINARI y la plataforma RIMA. Se utilizaron las palabras claves relacionadas a cada pregunta y se seleccionaron los artículos que abordasen el concepto, de manera directa, publicados durante el período comprendido entre 2003 y 2018.Decidimos por mayoría usar la Técnica de Grupo Nominal que es una de las 4 formas racionales de crear consenso de expertos o de grupos relacionados.

Downloads

Download data is not yet available.

References

- Marce M, Cristina Viana Z. Calidad de la evidencia y grado de recomendación. Guías de Práctica Clínica 2007; 7 Supl 1: 1-13.
- Holick MF, Binkley N, Bischoff-Ferrari HA, et al. Evaluation, treatment and prevention of vitamin D deciency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7): 1911-1930.
- Holick MF. Vitamin D status: Measurement, interpretation and clinical application. Ann Epidemiol 2009; 19: 73-8.
- Pal M, Datta S, Pradhan A, et al. Comparison between different methods of estimation of vitamin D. Advances in Biological Chemistry 2013; 3: 501-4.
- Friedman PA. Agents affecting mineral ion homeostasis and bone turnover. In: Brunton L, Chabner B, Knollman B, editors. Goodman & Gilman’s, The pharmacological basis of therapeutics. 12th ed. New York: The McGraw-Hill Companies Inc.; 2011. p. 1280-83.
- Christakos S, Dhawan P, Verstuyf A, et al. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016; 96(1): 365-408.
- Vitamina D. Consenso Colombiano de expertos. Med 2017; 39(2): 140-157.
- Vasquez- Awad D. Vitamina D y su importancia en la salud humana. Medicina 2013; 35(3): 214-226.
- P?udowski P, Karczmarewicz E, Bayer M, et al. Practical guidelines for the supplementation of vitamin D and the treatment of decits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deciency. Endokrynol Pol 2013; 64(4): 319-27.
- Chung, M.; Balk, E.; Brendel, M.; Ip, S.; Lau, J.; Lee, J.; Lichtenstein, A.; Patel, K.; Raman, G.; Tatsioni, A.; et al. Vitamin D and Calcium: Systematic Review of Health Outcomes; Evidence Report/Technology Assessment No. 183. (Prepared by Tufts Evidence-Based Practice Center under Contract No. 290-2007-10055-i); Agency for Healthcare Research and Quality: Rockville, MD, USA, 2009.
- Heaney, R.P. The vitamin D requirement in health and disease. J. Steroid Biochem. Mol. Biol. 2005; 97: 13–19.
- Vieth, R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am. J. Clin. Nutr. 1999; 69: 842–856.
- John Paul Ekwaru, Jennifer D. Zwicker, Michael F. Holick, Edward Giovannucci et al. The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteer. PLos One. 2014; 9(11): e111265
- Lenneke van Groningen, Susanne Opdenoordt, Adriaan van Sorge, Darryl Telting et al. Cholecalciferol loading dose guideline for vitamin D-decient adults. European Journal of Endocrinology 2010;162: 805–811
- Yi-Sheng Chao et al. The importance of dose, frequency and duration of vitamin D supplementation for plasma 25-hydroxyvitamin D. Nutrients 2013;5:4067-4078
- Sophia Ish-Shalom, Elena Segal, Tina Salganik, Batia Raz, et al. Comparison of Daily, Weekly, and Monthly Vitamin D3 in Ethanol Dosing Protocols for Two Months in Elderly Hip Fracture Patients. J Clin Endocrinol Metab. September 2008, 93(9):3430–3435
- Roger Francis, Terry Aspray, William Fraser, Neil Gittoes, Kassim Javaid, Helen Macdonald, Sanjeev Patel, Peter Selby, Nuttan Tanna, Claire Bowring. Vit D and Bone Health: A practical Clinical Guideline for Patient Management. Nacional Osteoporosis Society. 2016
- Elena Segal et al. Letters to the editor. JAGS 2004;52(3): 474.
- Reinhold Vieth. Vitamin D Toxicity, Policy and Science. J Bone Miner Res 2007;22:S2;V64-V68.
- US Preventive Services Task Force, Grossman DC, Curry SJ, Owens DK, et al. Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Apr 17;319(15):1592-1599.
- Holick MF. The vitamin D deciency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017; 18(2): 153-165.
- Malvy D, Guinot C, Preziosi P, et al. Relationship between vitamin D status and skin phototype in general adult population. Photochem Photobiol 2000; 71: 466-9.
- McKinlay AF, Diffey BL. A Reference spectrum for ultraviolet induced erythema in human skin. Comm Int D’Eclairage J 1987; 6: 17-22.
- Reyes Domínguez AI, Gómez de Tejada Romero MJ, Sosa Henríquez M, Rev Osteoporos Metab Miner. 2017; 9 (1) suplemento: 5-9.
- De Gruijl FR, Sterenborg HJ, Forbes PD, et al. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res. 1993; 53(1): 53-60.
- Fioletov V, McArthur L, Mathews T, Marrett L. On the relationship between erythemal and vitamin D action spectrum weighted ultraviolet radiation. J Photochem Photobiol B 2009; 95(1): 9-16.
- Gilaberte Y, Aguilera J, Carrascosa JM. La vitamina D evidencias y controversias. Actas Dermosiliogr 2011; 102(8): 572-588.
- Thacher TD, Clarke BL. Vitamin D insuciency. Mayo Clin Proc. 2011; 86(1): 50-60.
- Bjelakovic G, Gluud LL, Nikolova D, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev 2014; (1): CD007470.
- Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014; 348: g2035.
- Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong J et al. Vitamin D and risk of cause specic death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ 2014; 348: g1903
- Manson J, Cook NR, Lee I, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med. 2019; 380(1): 33-44.
- Zheng Y, Zhu J, Zhou M, et al. Meta-analysis of long term vitamin D supplementation on overall mortality. PLoS One. 2013; 8(12): e82109.
- Alejandro P, Constantinescu F. A review of osteoporosis in the older adult: an update. Rheum Dis Clin N Am 2018; 44(3): 437-451.
- Bolland MJ, Grey A, Reid IR. Should we prescribe calcium or vitamin D supplements to treat or prevent osteoporosis? Climateric 2015; 18(Suppl 2): 22-31.
- Gallagher JC. Vitamin D and falls - the dosage conundrum. Nat Rev Endocrinol 2016; 12(11): 680-684.
- Dhaliwal R, Aloia JF. Effect of vitamin D on falls and physical performance. Endocrinol Metab Clin N Am 2017; 46(4): 919–933.
- Iolascon G, de Sire A, Calaore D. Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: a retrospective study. Aging Clin Exp Res 2015; Suppl 1: S23-30.
- Tricco AC, Thomas SM, Veroniki AA. Comparisons of Interventions for Preventing Falls in Older Adults, A Systematic Review and Meta-analysis. JAMA 2017; 318(17): 1687-1699.
- Halfon M, Phan O, Teta D. Vitamin D: A Review on Its Effects on Muscle Strength the Risk of Fall, and Frailty. Biomed Res Int 2015; 2015: 953241.
- Lappe JM, Binkley N. Vitamin D and Sarcopenia/Falls. J Clin Densitom 2015; 18(4): 478-482.
- Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 2014; 383(9912): 146-155.
- Cauley JA, Greendale GA, Ruppert K, et al. Serum 25 hydroxyvitamin D, bone mineral density and fracture risk across the menopause. J Clin Endocrinol Metab 2015; 100(5): 2046–2054.
- Dawson-Hughes B. Vitamin D and muscle function. J Steroid Biochem Mol Biol 2017; 173: 313-316.
- Bouillon R. Can vitamin D prevent falls and fractures? Lancet Diabetes Endocrinol 2017; 5(6): 407-409.
- Smith LM, Gallagher JC, Suiter C. Medium doses of daily vitamin D decrease falls and higher doses of daily vitamin D3 increase falls: A randomized clinical trial. J Steroid Biochem Mol Biol 2017; 173: 317-322.
- Bolland MJ, Grey A, Avenell A. Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis. Lancet Diabetes Endocrinol 2018; 6(11): 847-858.
- Avenell A, Mak JC, O ?Connell D. Vit D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014; (4): CD000227.
- Grossman DC, Curry SJ, Owens DK, et al. Interventions to prevent falls in community-dwelling older adults: US Preventive Services Task Force recommendation statement. JAMA 2018; 319(16): 1696-1704.
- Skversky A, Kumar J, Abramowitz M, et al. Association of Glucocorticoid Use and Low 25-Hydroxyvitamin D Levels: Results from the National Health and Nutrition Examination Survey (NHANES): 2001–2006. J Clin Endocrinol Metab 2011; 96(12): 3838–3845.
- Davidson Z, Walker K, Truby H. Do Glucocorticosteroids Alter Vitamin D Status? A Systematic Review with Meta-Analyses of Observational Studies. J Clin Endocrinol Metab 2012; 97: 738–744.
- Buckley L, Humphrey MB. Glucocorticoid induced osteoporosis. N Engl J Med 2018; 379(26): 2547-56.
- Buckley L, Guyatt HA, Fink HA, et al. 2017 American College of Rheumatology Guideline for the prevention and treatment of glucocorticoid induced osteoporosis. Arthritis Rheumatol 2017; 69(8): 1521-37.
- Li N, Wu HM, Hang F, et al. Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface. Braz J Med Biol Res. 2017; 50(11): e6527.
- Gernard AD, Simhan HN, Baca KM, et al. Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial. BJOG 2017; 124(12): 1874–1882.
- Von Websky K, Hasan AA, Reichetzeder C. et al. Impact of vitamin D on pregnancy-related disorders and on offspring outcomes. J Steroid Biochem Mol Biol 2018; 180: 51-64.
- Harvey NC, Holroyd C, Ntani G. et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014; 18(45):1-190.
- Pilz S, Zittermann A, Obeid R. et al. The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data. Int J Environ Res Public Health 2018; 15(10). pii: E2241.
- De-Regil LM, Palacios C, Lombardo LK, et al. Vitamin D supplementation for women during pregnancy. Sao Paulo Med J 2016; 134(3): 274-5.
- Fung JL, Hartman TJ, Schleicher RL. Et al. Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study. Fertil Steril 2017; 108(2): 302-311.
- Pérez-López FR, Pasupuleti V, Mezones-Holguin E, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015; 103(5): 1278-88.
- Sahoo SK, Katam KK, Das V, et al. Maternal vitamin D supplementation in pregnancy and offspring outcomes: a double-blind randomized placebo-controlled trial. J Bone Miner Metab 2017; 35(4): 464-471.
- Arnold DL, Enquobahrie DA, Qiu C, et al. Early Pregnancy Maternal Vitamin D Concentrations and Risk of Gestational Diabetes Mellitus. Paediatr Perinat Epidemiol 2015; 29(3): 200–210.
- Miliku K, Vinkhuyzen A, Blanken LM, et al. Maternal Vitamin D Concentrations During Pregnancy, Fetal Growth Patterns and Risks of Adverse Birth Outcomes. Am J Clin Nutr 2016; 103(6): 1514–1522.
- O’Callaghan KM, Kiely M. Systematic Review of Vitamin D and Hypertensive Disorders of Pregnancy. Nutrients 2018; 10(3): 294-311.
- Palacios C, De-Regil LM, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes. J Steroid Biochem Mol Biol 2016; 164: 148-155.
- Gençosmano?lu Türkmen G, Yilmaz V, Da?lar K, et al. Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy. J Obstet Gynaecol Res 2018; 44(9): 1712-1718.
- Hollis BW, Johnson D, Hulsey TC, et al Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J. Bone Miner Res. 2011; 26(10): 2341–2357.
- Hollis BW, Wagner CL. Vitamin D and pregnancy: Skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013; 92(2): 128–139.
- Song SJ, Zhou L, Si S. et al. The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013; 8(12): e85081.
- Vandevijvere S, Amsalkhir S, Van Oyen H, Moreno-Reyes R. High prevalence of vitamin D deficiency in pregnant women: a national cross-sectional survey. PLoS One 2012; 7(8): e43868.
- Dovnik A, Mujezinovi? F. The Association of Vitamin D Levels with Common Pregnancy Complications. Nutrients 2018; 10(7). pii: E867.
- Norman PE, Powell JT. Vitamin D and Cardiovascular Disease. Circ Res. 2014; 114(2): 379-393.
- Allan GM, Cranston L, Lindblad A, et al. Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs. J Gen Inter Med 2016; 31(7): 780-91
- Autier P, Mullie P, Macacu A, et al. Effect of Vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomized trials. Lancet Diabetes Endocrinol 2017; 5(12): 986-1004.
- Schnatz P. Manson JE. Vitamin D and Cardiovascular Disease: An Appraisal of the Evidence. Clin Chem 2014; 60(4): 600-9.
- Wang L, Song Y, Manson JE, et al. Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Studies. Circ Cardiovasc Qual Outcomes 2012; 5(6): 819-829.
- Makariu SE, Elisaf M, Challa A, et al. No effect of Vitamin D supplementation on cardiovascular risk factors in subjects with metabolic syndrome: a pilot randomized study. Arch Med Sci Atheroscler Dis 2017; 2: e52-e60.
- Singh P. Treatment of Vitamin D Deciency and Comorbidities: A Review. J Assoc Physicians India. 2018; 66(1): 75-82.
- Ford JA, MacLennan GS, Avenell A, et al. Cardiovascular disease and vitamin D supplementation: trial, analysis, systematic review, and meta-analysis. Am J Clin Nutr 2014; 100(3): 746-55.
- Beveridge L, Khan F, Struthers AD, et al. Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta-Analysis. J Am Heart Assoc. 2018; 7(11). pii e008273.
- Hussin AM, Ashor AW, Schoenmakers I, et al. Effects of Vitamin D supplementation on endothelial function: a systematic review and meta-analysis of randomized trials. Eur J Nutr 2017; 56(3): 1095-1104.
- Glueck Ch, Jetty V, Rothschild M, et al. Associations between Serum 25-hydroxyvitamin D and Lipids, Lipoprotein Cholesterols, and Homocysteine. North Am J Med Sci 2016; 8(7): 284-90.
- Scragg R, Stewart AW, Waayer D, et al Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study A Randomized Clinical Trial. JAMA Cardiol 2017; 2(6): 608-616
- Yaniel Castro T, Anamary Fleites P, Raimundo Carmona P, Marlen Vega V, et al. Décit de la vitamina D e Hipertensión Arterial. Evidencias a favor. Revista Colombiana de Cardiología. 2016; 23(1):42-48.
- Mondull AM, Weinsten SJ, Layne TM, Albanes D. Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges. Epidemiol Rev 2017; 39(1): 28-48.
- Garland C, Garland F, Gorham E, et al. The Role of Vitamin D in Cancer Prevention. Am J Public Heal 2006; 96(2): 252-61.
- Holick MF. Cancer, sunlight and vitamin D. J Clin Transl Endocrinol 2014; 1(4): 179-186.
- Teleni L, Baker J, Koczwara B, et al. Clinical outcomes of Vitamin D deciency and supplementation in cancer patients. Nutr Rev 2013; 71(9): 611-621.
- Calmarza P, Sanz París A, Prieto López C, et al. Vitamin D levels in patients with recent cancer diagnosis. Nutr Hosp 2018; 35(4): 903-908.
- Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol 2014; 2(4): 307–20.
- Jacobs ET, Kohler LN, Kunihiro AG, Jurutka PW. Vitamin D and Colorectal, Breast, and Prostate Cancers: A Review of the Epidemiological Evidence. J Cancer 2016; 7(3): 232-240.
- Maalmi H, Ordoñez-Mena JM, Schöttker B, Brenner H. Serum 25-hydroxivitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies. Eur J Cancer 2014; 50(8): 1510-1521.
- Barnett CM, Nielson CM, Shannon J, et al. Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men. Cancer Causes Control 2010; 21(8):1297–1303.
- Xu Y, Shao X, Yao Y, et al. Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new ndings from an updated meta-analysis. J Cancer Res Clin Oncol. 2014; 140(9): 1465-77.
- Scragg R, Khaw KT, Toop L, et al. Monthly High-Dose Vitamin D Supplementation and Cancer Risk: A Post Hoc Analysis of the Vitamin D Assessment Randomized Clinical Trial. JAMA Oncol 2018; 4(11): e182178.
- Keum N, Giovannucci E. Vitamin D supplements and cancer incidence and mortality: a meta-analysis. Br J Cancer 2014; 111(5): 976–980.
- Vaughan-Shaw PG, O’Sullivan F, Farrington SM, et al. The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis. Br J Cancer 2017; 116(8): 1092–1110.
- Franco AS, Freitas TQ, Bernardo WM, Pereira RMR. Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis. Medicine (Baltimore) 2017; 96(23): e7024.
- Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013; 5(7): 2502-21.
- Gatenby P, Lucas R, Swaminathan A. Vitamin D deciency and risk for rheumatic diseases: an update. Curr Opin Rheumatol 2013; 25(2): 184-191.
- Castro D. et al. Vitamin D in rheumatic diseases. Rev Osteoporos Metab Miner. 2017;9(Supl 1):S31-39
- Rossini M, Gatti D, Viapiana O, et al. Vitamin D and rheumatic diseases. Reumatismo 2014; 66(2): 153-170.
- Pfeffer PE, Hawrylowicz CM. Vitamin D in Asthma. Mechanism of Action and Considerations for Clinical Trials. Chest 2018; 153(5): 1229-1239.
- Sassi F, Tamone C, D’Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients 2018; 10(11): pii E1656.
- Martineau AR, Cates CJ, Urashima M, et al. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2016 Sep 5; 9: CD011511.
- Jollife DA, Greenberg L, Hooper RL, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysys of individual participant data. Lancet Respir Med 2017; 5(11): 881-890.
- Orban NT, Saleh H, Durham S. Allergic and nonallergic rhinitis. In: Allergy. Principles and Practice. Mosby Elsevier. 2009; 973-90. 16.
- Rorie A, Goldner WS, Lyden E, Poole JA. Benecial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. Ann Allergy Asthma Immunol. 2014; 112(4): 376-82.
- Ritterhouse LL, Lu R, Shah HB, et al. Vitamin D deciency in a multiethnic healthy control cohort and altered immune response in vitamin D decient European-American healthy controls. PLos One 2014; 9(4): e945000.
- Kim G, Bae JH. Vitamin D and atopic dermatitis: A systematic review and meta-analysis. Nutrition 2016; 32(9): 913-20.
- Pannu PK, Zhao Y, Soares MJ. Reductions in body weight and percent fat mass increase the vitamin D status of obese subjects: a systematic review and metaregression analysis. Nutr Res 2016; 36(3): 201–13.
- Yajnik CS, Yudkin JS. The Y-Y paradox. Lancet 2004; 363(9403): 163.
- Ding C., Gao D, Wilding J, et al. Vitamin D signalling in adipose tissue. Br J Nutr. 2012 Dec 14; 108(11): 1915-23.
- Pereira-Santos M, Costa PR, Assis AM, et al. Obesity and vitamin D deciency: a systematic review and meta-analysis. Obes Rev 2015; 16(4): 341–9.
- Vanlint S. Vitamin D and Obesity. Nutrients 2013; 5(3): 949-956.
- Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690–3.
- Mallard SR, Howe AS, Houghton LA. Vitamin D status and weight loss: a systematic review and meta-analysis of randomized and nonrandomized controlled weight-loss trials. Am J Clin Nutr 2016; 104(4): 1151–9.
- Gangloff A, Bergeron J, Pelletier-Beaumont E, et al. Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men. Int J Obes (Lon) 2015; 39(11): 1638–43.
- M.ª J. Amaya García, F. J. Vilchez López, C. Campos Martín, P. Sánchez, et al. Revisión Micronutrientes en Cirugía Bariátrica, Nutr Hosp. 2012; 27:349-361
- Chakhtoura MT, Nakhoul NN, Shawwa K, et al. Hypovitaminosis D in bariatric surgery: A systematic review of observational studies. Metabolism 2016; 65(4): 574–85.
- Winters SJ, Chennubhatla R, Wang C, Miller JJ. Inuence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women. Metabolism 2009; 58(4): 438–42.
- Rosenstreich SJ, Rich C, Volwiler W. Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. J Clin Invest 1971; 50(3): 679–87.
- Mawer EB, Backhouse J, Holman CA, et al. The distribution and storage of vitamin D and its metabolites in human tissues. Clin Sci 1972; 43(3): 413–31.
- Heaney RP, Horst RL, Cullen DM, Armas LA. Vitamin D3 distribution and status in the body. J Am Coll Nutr. 2009; 28(3): 252–6.
- Sergeev IN. Vitamin D-Cellular Ca2+ link to obesity and diabetes. J Steroid Biochem Mol Biol. 2016; 164: 326–30.
- Pathak K, Soares MJ, Calton EK, et al. Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2014; 15(6): 528–37.
- Ekwaru JP, Zwicker JD, Holick MF, et al. The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS One 2014; 9(11): e111265.
- Glueck CJ, Jetty V, Rothschild M, et al. Associations between serum 25-hydroxyvitamin D and lipids, lipoprotein cholesterols, and homocysteine. North Am J Med Sci 2016; 8(7): 284-90.
- Heath AK, Williamson EJ, Hodge AM, et al. Vitamin D status and the risk of type 2 diabetes: The Melbourne Collaborative Cohort Study. Diabetes Res Clin Pract 2018; 149: 179-187.
- Angellotti E, D Alessio D, Dawson-Hughes B, et al. Vitamin D Supplementation in Patients With Type 2 Diabetes: The Vitamin D for Established Type 2 Diabetes (DDM2) Study. J Endocr Soc. 2018; 2(4): 310–321.
- Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J Steroid Biochem Mol Biol 2018; 175: 177-189.
- Hyppönen E, Boucher BJ. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities. Nutr Rev. 2018; 76(9): 678-692.
- Alloubani A., Akhu-Zaheya L., Samara R., Abdulhaz I., Saleh A., Altowijri A. Relationship between Vitamin D Deciency, Diabetes, and Obesity. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2019; 13(2): 1457-1461.
- Von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D decient - a randomised, placebo-controlled trial. Br J Nutr. 2010; 103(4): 549–55.
- Franceschi C, Capri M, Monti D, et al. Inammaging and anti-inammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128(1): 92–105.
- Franceschi C, Bonafé M, Valensin S, et al. Inamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000; 908: 244–254.
- Gonçalves de Carvalho CM, Ribeiro SM. Aging, low-grade systemic inammation and vitamin D: a mini-review. Eur J Clin Nutr 2017; 71(4): 434-440.
- Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007; 167(16): 1730–1737.
- Urruticoechea-Arana A, Martin-Martinez MA, Castaneda S, et al. Vitamin D deciency in chronic inammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study. Arthritis Res Ther 2015; 17: 211.
- Binkley N. Does low vitamin D status contribute to “age-related” morbidity? J Bone Miner Res 2007; 22(S2): V55–V58.
- Llewellyn DJ. Lang IA, Langa KM, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010; 170(13); 1135-41.
- Annweiler C, Beauchet O. Questioning vitamin D status of elderly fallers and nonfallers; a meta-analysis to address a “forgotten step”. J Intern Med. 2015; 277(1); 16-44.
- Verlaan S, Maier AB, Bauer JM, et al. Sucient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study. Clin Nutr. 2018;37(2): 551-557.
- El-Hajj Fuleihan G, Baddoura R, Habib RH, et al. Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial. Am J Clin Nutr. 2016; 104 (2): 315-323.
- Daniel Owens, Richard Allison y Graeme Close; Vitamin D and the Athletes: Current Perspectives and New Challenges. Sports Med 2018; 48 (1): 3-16
- Dana Ogan and Kelly Pritchett. Vitamin D and the Athlete: Risk, Recommendations and Benets. Nutrients 2013; 5: 1856-1868
- Constantini NW et al. High prevalence of vitamin D insuciency in athletes and dancers. Clin J Sport Med 2010; 20(5): 368-371
- Lovell G. Vitamin D status of female in an elite gymnastics program. Clin J Sports Med. 2008; 18(2): 159-161
- Michael Angeline, Albert Gee, Michael Shindle, Russel Warren and Scott Rodeo. The Effects of Vitamin D Deciency in Athletes. The American Journal of Sports Medicine 2013; 41(2): 461-464
- Micah Dunn, Jacalyn Robert-McComb. Vitamin D Deciency in College-Age Male Basketabll Players: Sports Medicien Physicians Can Play an Important Role; International Journal of Research Studies in Medical and Health Sciences, 2017; 2(6): 8-15
- Dylan Dahlquist, Brad Dieter and Michael Kowhle; Pausible ergogenic effects of vitamin D on athletic performance and recovery. J. Int Soc of Sport Nutr. 2015; 12: 33

Keywords

PDF (Español (España))

Resumen visto - 10 veces
PDF (Español (España)) descargado - 0

Licencia

Content Top

[1] - Marce M, Cristina Viana Z. Calidad de la evidencia y grado de recomendación. Guías de Práctica Clínica 2007; 7 Supl 1: 1-13.

[2] - Holick MF, Binkley N, Bischoff-Ferrari HA, et al. Evaluation, treatment and prevention of vitamin D deciency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7): 1911-1930.

[3] - Holick MF. Vitamin D status: Measurement, interpretation and clinical application. Ann Epidemiol 2009; 19: 73-8.

[4] - Pal M, Datta S, Pradhan A, et al. Comparison between different methods of estimation of vitamin D. Advances in Biological Chemistry 2013; 3: 501-4.

[5] - Friedman PA. Agents affecting mineral ion homeostasis and bone turnover. In: Brunton L, Chabner B, Knollman B, editors. Goodman & Gilman’s, The pharmacological basis of therapeutics. 12th ed. New York: The McGraw-Hill Companies Inc.; 2011. p. 1280-83.

[6] - Christakos S, Dhawan P, Verstuyf A, et al. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016; 96(1): 365-408.

[7] - Vitamina D. Consenso Colombiano de expertos. Med 2017; 39(2): 140-157.

[8] - Vasquez- Awad D. Vitamina D y su importancia en la salud humana. Medicina 2013; 35(3): 214-226.

[9] - P?udowski P, Karczmarewicz E, Bayer M, et al. Practical guidelines for the supplementation of vitamin D and the treatment of decits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deciency. Endokrynol Pol 2013; 64(4): 319-27.

[10] - Chung, M.; Balk, E.; Brendel, M.; Ip, S.; Lau, J.; Lee, J.; Lichtenstein, A.; Patel, K.; Raman, G.; Tatsioni, A.; et al. Vitamin D and Calcium: Systematic Review of Health Outcomes; Evidence Report/Technology Assessment No. 183. (Prepared by Tufts Evidence-Based Practice Center under Contract No. 290-2007-10055-i); Agency for Healthcare Research and Quality: Rockville, MD, USA, 2009.

[11] - Heaney, R.P. The vitamin D requirement in health and disease. J. Steroid Biochem. Mol. Biol. 2005; 97: 13–19.

[12] - Vieth, R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am. J. Clin. Nutr. 1999; 69: 842–856.

[13] - John Paul Ekwaru, Jennifer D. Zwicker, Michael F. Holick, Edward Giovannucci et al. The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteer. PLos One. 2014; 9(11): e111265

[14] - Lenneke van Groningen, Susanne Opdenoordt, Adriaan van Sorge, Darryl Telting et al. Cholecalciferol loading dose guideline for vitamin D-decient adults. European Journal of Endocrinology 2010;162: 805–811

[15] - Yi-Sheng Chao et al. The importance of dose, frequency and duration of vitamin D supplementation for plasma 25-hydroxyvitamin D. Nutrients 2013;5:4067-4078

[16] - Sophia Ish-Shalom, Elena Segal, Tina Salganik, Batia Raz, et al. Comparison of Daily, Weekly, and Monthly Vitamin D3 in Ethanol Dosing Protocols for Two Months in Elderly Hip Fracture Patients. J Clin Endocrinol Metab. September 2008, 93(9):3430–3435

[17] - Roger Francis, Terry Aspray, William Fraser, Neil Gittoes, Kassim Javaid, Helen Macdonald, Sanjeev Patel, Peter Selby, Nuttan Tanna, Claire Bowring. Vit D and Bone Health: A practical Clinical Guideline for Patient Management. Nacional Osteoporosis Society. 2016

[18] - Elena Segal et al. Letters to the editor. JAGS 2004;52(3): 474.

[19] - Reinhold Vieth. Vitamin D Toxicity, Policy and Science. J Bone Miner Res 2007;22:S2;V64-V68.

[20] - US Preventive Services Task Force, Grossman DC, Curry SJ, Owens DK, et al. Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Apr 17;319(15):1592-1599.

[21] - Holick MF. The vitamin D deciency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017; 18(2): 153-165.

[22] - Malvy D, Guinot C, Preziosi P, et al. Relationship between vitamin D status and skin phototype in general adult population. Photochem Photobiol 2000; 71: 466-9.

[23] - McKinlay AF, Diffey BL. A Reference spectrum for ultraviolet induced erythema in human skin. Comm Int D’Eclairage J 1987; 6: 17-22.

[24] - Reyes Domínguez AI, Gómez de Tejada Romero MJ, Sosa Henríquez M, Rev Osteoporos Metab Miner. 2017; 9 (1) suplemento: 5-9.

[25] - De Gruijl FR, Sterenborg HJ, Forbes PD, et al. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res. 1993; 53(1): 53-60.

[26] - Fioletov V, McArthur L, Mathews T, Marrett L. On the relationship between erythemal and vitamin D action spectrum weighted ultraviolet radiation. J Photochem Photobiol B 2009; 95(1): 9-16.

[27] - Gilaberte Y, Aguilera J, Carrascosa JM. La vitamina D evidencias y controversias. Actas Dermosiliogr 2011; 102(8): 572-588.

[28] - Thacher TD, Clarke BL. Vitamin D insuciency. Mayo Clin Proc. 2011; 86(1): 50-60.

[29] - Bjelakovic G, Gluud LL, Nikolova D, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev 2014; (1): CD007470.

[30] - Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014; 348: g2035.

[31] - Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong J et al. Vitamin D and risk of cause specic death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ 2014; 348: g1903

[32] - Manson J, Cook NR, Lee I, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med. 2019; 380(1): 33-44.

[33] - Zheng Y, Zhu J, Zhou M, et al. Meta-analysis of long term vitamin D supplementation on overall mortality. PLoS One. 2013; 8(12): e82109.

[34] - Alejandro P, Constantinescu F. A review of osteoporosis in the older adult: an update. Rheum Dis Clin N Am 2018; 44(3): 437-451.

[35] - Bolland MJ, Grey A, Reid IR. Should we prescribe calcium or vitamin D supplements to treat or prevent osteoporosis? Climateric 2015; 18(Suppl 2): 22-31.

[36] - Gallagher JC. Vitamin D and falls - the dosage conundrum. Nat Rev Endocrinol 2016; 12(11): 680-684.

[37] - Dhaliwal R, Aloia JF. Effect of vitamin D on falls and physical performance. Endocrinol Metab Clin N Am 2017; 46(4): 919–933.

[38] - Iolascon G, de Sire A, Calaore D. Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: a retrospective study. Aging Clin Exp Res 2015; Suppl 1: S23-30.

[39] - Tricco AC, Thomas SM, Veroniki AA. Comparisons of Interventions for Preventing Falls in Older Adults, A Systematic Review and Meta-analysis. JAMA 2017; 318(17): 1687-1699.

[40] - Halfon M, Phan O, Teta D. Vitamin D: A Review on Its Effects on Muscle Strength the Risk of Fall, and Frailty. Biomed Res Int 2015; 2015: 953241.

[41] - Lappe JM, Binkley N. Vitamin D and Sarcopenia/Falls. J Clin Densitom 2015; 18(4): 478-482.

[42] - Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 2014; 383(9912): 146-155.

[43] - Cauley JA, Greendale GA, Ruppert K, et al. Serum 25 hydroxyvitamin D, bone mineral density and fracture risk across the menopause. J Clin Endocrinol Metab 2015; 100(5): 2046–2054.

[44] - Dawson-Hughes B. Vitamin D and muscle function. J Steroid Biochem Mol Biol 2017; 173: 313-316.

[45] - Bouillon R. Can vitamin D prevent falls and fractures? Lancet Diabetes Endocrinol 2017; 5(6): 407-409.

[46] - Smith LM, Gallagher JC, Suiter C. Medium doses of daily vitamin D decrease falls and higher doses of daily vitamin D3 increase falls: A randomized clinical trial. J Steroid Biochem Mol Biol 2017; 173: 317-322.

[47] - Bolland MJ, Grey A, Avenell A. Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis. Lancet Diabetes Endocrinol 2018; 6(11): 847-858.

[48] - Avenell A, Mak JC, O ?Connell D. Vit D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014; (4): CD000227.

[49] - Grossman DC, Curry SJ, Owens DK, et al. Interventions to prevent falls in community-dwelling older adults: US Preventive Services Task Force recommendation statement. JAMA 2018; 319(16): 1696-1704.

[50] - Skversky A, Kumar J, Abramowitz M, et al. Association of Glucocorticoid Use and Low 25-Hydroxyvitamin D Levels: Results from the National Health and Nutrition Examination Survey (NHANES): 2001–2006. J Clin Endocrinol Metab 2011; 96(12): 3838–3845.

[51] - Davidson Z, Walker K, Truby H. Do Glucocorticosteroids Alter Vitamin D Status? A Systematic Review with Meta-Analyses of Observational Studies. J Clin Endocrinol Metab 2012; 97: 738–744.

[52] - Buckley L, Humphrey MB. Glucocorticoid induced osteoporosis. N Engl J Med 2018; 379(26): 2547-56.

[53] - Buckley L, Guyatt HA, Fink HA, et al. 2017 American College of Rheumatology Guideline for the prevention and treatment of glucocorticoid induced osteoporosis. Arthritis Rheumatol 2017; 69(8): 1521-37.

[54] - Li N, Wu HM, Hang F, et al. Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface. Braz J Med Biol Res. 2017; 50(11): e6527.

[55] - Gernard AD, Simhan HN, Baca KM, et al. Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial. BJOG 2017; 124(12): 1874–1882.

[56] - Von Websky K, Hasan AA, Reichetzeder C. et al. Impact of vitamin D on pregnancy-related disorders and on offspring outcomes. J Steroid Biochem Mol Biol 2018; 180: 51-64.

[57] - Harvey NC, Holroyd C, Ntani G. et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014; 18(45):1-190.

[58] - Pilz S, Zittermann A, Obeid R. et al. The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data. Int J Environ Res Public Health 2018; 15(10). pii: E2241.

[59] - De-Regil LM, Palacios C, Lombardo LK, et al. Vitamin D supplementation for women during pregnancy. Sao Paulo Med J 2016; 134(3): 274-5.

[60] - Fung JL, Hartman TJ, Schleicher RL. Et al. Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study. Fertil Steril 2017; 108(2): 302-311.

[61] - Pérez-López FR, Pasupuleti V, Mezones-Holguin E, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015; 103(5): 1278-88.

[62] - Sahoo SK, Katam KK, Das V, et al. Maternal vitamin D supplementation in pregnancy and offspring outcomes: a double-blind randomized placebo-controlled trial. J Bone Miner Metab 2017; 35(4): 464-471.

[63] - Arnold DL, Enquobahrie DA, Qiu C, et al. Early Pregnancy Maternal Vitamin D Concentrations and Risk of Gestational Diabetes Mellitus. Paediatr Perinat Epidemiol 2015; 29(3): 200–210.

[64] - Miliku K, Vinkhuyzen A, Blanken LM, et al. Maternal Vitamin D Concentrations During Pregnancy, Fetal Growth Patterns and Risks of Adverse Birth Outcomes. Am J Clin Nutr 2016; 103(6): 1514–1522.

[65] - O’Callaghan KM, Kiely M. Systematic Review of Vitamin D and Hypertensive Disorders of Pregnancy. Nutrients 2018; 10(3): 294-311.

[66] - Palacios C, De-Regil LM, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes. J Steroid Biochem Mol Biol 2016; 164: 148-155.

[67] - Gençosmano?lu Türkmen G, Yilmaz V, Da?lar K, et al. Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy. J Obstet Gynaecol Res 2018; 44(9): 1712-1718.

[68] - Hollis BW, Johnson D, Hulsey TC, et al Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J. Bone Miner Res. 2011; 26(10): 2341–2357.

[69] - Hollis BW, Wagner CL. Vitamin D and pregnancy: Skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013; 92(2): 128–139.

[70] - Song SJ, Zhou L, Si S. et al. The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013; 8(12): e85081.

[71] - Vandevijvere S, Amsalkhir S, Van Oyen H, Moreno-Reyes R. High prevalence of vitamin D deficiency in pregnant women: a national cross-sectional survey. PLoS One 2012; 7(8): e43868.

[72] - Dovnik A, Mujezinovi? F. The Association of Vitamin D Levels with Common Pregnancy Complications. Nutrients 2018; 10(7). pii: E867.

[73] - Norman PE, Powell JT. Vitamin D and Cardiovascular Disease. Circ Res. 2014; 114(2): 379-393.

[74] - Allan GM, Cranston L, Lindblad A, et al. Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs. J Gen Inter Med 2016; 31(7): 780-91

[75] - Autier P, Mullie P, Macacu A, et al. Effect of Vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomized trials. Lancet Diabetes Endocrinol 2017; 5(12): 986-1004.

[76] - Schnatz P. Manson JE. Vitamin D and Cardiovascular Disease: An Appraisal of the Evidence. Clin Chem 2014; 60(4): 600-9.

[77] - Wang L, Song Y, Manson JE, et al. Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Studies. Circ Cardiovasc Qual Outcomes 2012; 5(6): 819-829.

[78] - Makariu SE, Elisaf M, Challa A, et al. No effect of Vitamin D supplementation on cardiovascular risk factors in subjects with metabolic syndrome: a pilot randomized study. Arch Med Sci Atheroscler Dis 2017; 2: e52-e60.

[79] - Singh P. Treatment of Vitamin D Deciency and Comorbidities: A Review. J Assoc Physicians India. 2018; 66(1): 75-82.

[80] - Ford JA, MacLennan GS, Avenell A, et al. Cardiovascular disease and vitamin D supplementation: trial, analysis, systematic review, and meta-analysis. Am J Clin Nutr 2014; 100(3): 746-55.

[81] - Beveridge L, Khan F, Struthers AD, et al. Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta-Analysis. J Am Heart Assoc. 2018; 7(11). pii e008273.

[82] - Hussin AM, Ashor AW, Schoenmakers I, et al. Effects of Vitamin D supplementation on endothelial function: a systematic review and meta-analysis of randomized trials. Eur J Nutr 2017; 56(3): 1095-1104.

[83] - Glueck Ch, Jetty V, Rothschild M, et al. Associations between Serum 25-hydroxyvitamin D and Lipids, Lipoprotein Cholesterols, and Homocysteine. North Am J Med Sci 2016; 8(7): 284-90.

[84] - Scragg R, Stewart AW, Waayer D, et al Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study A Randomized Clinical Trial. JAMA Cardiol 2017; 2(6): 608-616

[85] - Yaniel Castro T, Anamary Fleites P, Raimundo Carmona P, Marlen Vega V, et al. Décit de la vitamina D e Hipertensión Arterial. Evidencias a favor. Revista Colombiana de Cardiología. 2016; 23(1):42-48.

[86] - Mondull AM, Weinsten SJ, Layne TM, Albanes D. Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges. Epidemiol Rev 2017; 39(1): 28-48.

[87] - Garland C, Garland F, Gorham E, et al. The Role of Vitamin D in Cancer Prevention. Am J Public Heal 2006; 96(2): 252-61.

[88] - Holick MF. Cancer, sunlight and vitamin D. J Clin Transl Endocrinol 2014; 1(4): 179-186.

[89] - Teleni L, Baker J, Koczwara B, et al. Clinical outcomes of Vitamin D deciency and supplementation in cancer patients. Nutr Rev 2013; 71(9): 611-621.

[90] - Calmarza P, Sanz París A, Prieto López C, et al. Vitamin D levels in patients with recent cancer diagnosis. Nutr Hosp 2018; 35(4): 903-908.

[91] - Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol 2014; 2(4): 307–20.

[92] - Jacobs ET, Kohler LN, Kunihiro AG, Jurutka PW. Vitamin D and Colorectal, Breast, and Prostate Cancers: A Review of the Epidemiological Evidence. J Cancer 2016; 7(3): 232-240.

[93] - Maalmi H, Ordoñez-Mena JM, Schöttker B, Brenner H. Serum 25-hydroxivitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies. Eur J Cancer 2014; 50(8): 1510-1521.

[94] - Barnett CM, Nielson CM, Shannon J, et al. Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men. Cancer Causes Control 2010; 21(8):1297–1303.

[95] - Xu Y, Shao X, Yao Y, et al. Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new ndings from an updated meta-analysis. J Cancer Res Clin Oncol. 2014; 140(9): 1465-77.

[96] - Scragg R, Khaw KT, Toop L, et al. Monthly High-Dose Vitamin D Supplementation and Cancer Risk: A Post Hoc Analysis of the Vitamin D Assessment Randomized Clinical Trial. JAMA Oncol 2018; 4(11): e182178.

[97] - Keum N, Giovannucci E. Vitamin D supplements and cancer incidence and mortality: a meta-analysis. Br J Cancer 2014; 111(5): 976–980.

[98] - Vaughan-Shaw PG, O’Sullivan F, Farrington SM, et al. The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis. Br J Cancer 2017; 116(8): 1092–1110.

[99] - Franco AS, Freitas TQ, Bernardo WM, Pereira RMR. Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis. Medicine (Baltimore) 2017; 96(23): e7024.

[100] - Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013; 5(7): 2502-21.

[101] - Gatenby P, Lucas R, Swaminathan A. Vitamin D deciency and risk for rheumatic diseases: an update. Curr Opin Rheumatol 2013; 25(2): 184-191.

[102] - Castro D. et al. Vitamin D in rheumatic diseases. Rev Osteoporos Metab Miner. 2017;9(Supl 1):S31-39

[103] - Rossini M, Gatti D, Viapiana O, et al. Vitamin D and rheumatic diseases. Reumatismo 2014; 66(2): 153-170.

[104] - Pfeffer PE, Hawrylowicz CM. Vitamin D in Asthma. Mechanism of Action and Considerations for Clinical Trials. Chest 2018; 153(5): 1229-1239.

[105] - Sassi F, Tamone C, D’Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients 2018; 10(11): pii E1656.

[106] - Martineau AR, Cates CJ, Urashima M, et al. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2016 Sep 5; 9: CD011511.

[107] - Jollife DA, Greenberg L, Hooper RL, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysys of individual participant data. Lancet Respir Med 2017; 5(11): 881-890.

[108] - Orban NT, Saleh H, Durham S. Allergic and nonallergic rhinitis. In: Allergy. Principles and Practice. Mosby Elsevier. 2009; 973-90. 16.

[109] - Rorie A, Goldner WS, Lyden E, Poole JA. Benecial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. Ann Allergy Asthma Immunol. 2014; 112(4): 376-82.

[110] - Ritterhouse LL, Lu R, Shah HB, et al. Vitamin D deciency in a multiethnic healthy control cohort and altered immune response in vitamin D decient European-American healthy controls. PLos One 2014; 9(4): e945000.

[111] - Kim G, Bae JH. Vitamin D and atopic dermatitis: A systematic review and meta-analysis. Nutrition 2016; 32(9): 913-20.

[112] - Pannu PK, Zhao Y, Soares MJ. Reductions in body weight and percent fat mass increase the vitamin D status of obese subjects: a systematic review and metaregression analysis. Nutr Res 2016; 36(3): 201–13.

[113] - Yajnik CS, Yudkin JS. The Y-Y paradox. Lancet 2004; 363(9403): 163.

[114] - Ding C., Gao D, Wilding J, et al. Vitamin D signalling in adipose tissue. Br J Nutr. 2012 Dec 14; 108(11): 1915-23.

[115] - Pereira-Santos M, Costa PR, Assis AM, et al. Obesity and vitamin D deciency: a systematic review and meta-analysis. Obes Rev 2015; 16(4): 341–9.

[116] - Vanlint S. Vitamin D and Obesity. Nutrients 2013; 5(3): 949-956.

[117] - Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690–3.

[118] - Mallard SR, Howe AS, Houghton LA. Vitamin D status and weight loss: a systematic review and meta-analysis of randomized and nonrandomized controlled weight-loss trials. Am J Clin Nutr 2016; 104(4): 1151–9.

[119] - Gangloff A, Bergeron J, Pelletier-Beaumont E, et al. Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men. Int J Obes (Lon) 2015; 39(11): 1638–43.

[120] - M.ª J. Amaya García, F. J. Vilchez López, C. Campos Martín, P. Sánchez, et al. Revisión Micronutrientes en Cirugía Bariátrica, Nutr Hosp. 2012; 27:349-361

[121] - Chakhtoura MT, Nakhoul NN, Shawwa K, et al. Hypovitaminosis D in bariatric surgery: A systematic review of observational studies. Metabolism 2016; 65(4): 574–85.

[122] - Winters SJ, Chennubhatla R, Wang C, Miller JJ. Inuence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women. Metabolism 2009; 58(4): 438–42.

[123] - Rosenstreich SJ, Rich C, Volwiler W. Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. J Clin Invest 1971; 50(3): 679–87.

[124] - Mawer EB, Backhouse J, Holman CA, et al. The distribution and storage of vitamin D and its metabolites in human tissues. Clin Sci 1972; 43(3): 413–31.

[125] - Heaney RP, Horst RL, Cullen DM, Armas LA. Vitamin D3 distribution and status in the body. J Am Coll Nutr. 2009; 28(3): 252–6.

[126] - Sergeev IN. Vitamin D-Cellular Ca2+ link to obesity and diabetes. J Steroid Biochem Mol Biol. 2016; 164: 326–30.

[127] - Pathak K, Soares MJ, Calton EK, et al. Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2014; 15(6): 528–37.

[128] - Ekwaru JP, Zwicker JD, Holick MF, et al. The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS One 2014; 9(11): e111265.

[129] - Glueck CJ, Jetty V, Rothschild M, et al. Associations between serum 25-hydroxyvitamin D and lipids, lipoprotein cholesterols, and homocysteine. North Am J Med Sci 2016; 8(7): 284-90.

[130] - Heath AK, Williamson EJ, Hodge AM, et al. Vitamin D status and the risk of type 2 diabetes: The Melbourne Collaborative Cohort Study. Diabetes Res Clin Pract 2018; 149: 179-187.

[131] - Angellotti E, D Alessio D, Dawson-Hughes B, et al. Vitamin D Supplementation in Patients With Type 2 Diabetes: The Vitamin D for Established Type 2 Diabetes (DDM2) Study. J Endocr Soc. 2018; 2(4): 310–321.

[132] - Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J Steroid Biochem Mol Biol 2018; 175: 177-189.

[133] - Hyppönen E, Boucher BJ. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities. Nutr Rev. 2018; 76(9): 678-692.

[134] - Alloubani A., Akhu-Zaheya L., Samara R., Abdulhaz I., Saleh A., Altowijri A. Relationship between Vitamin D Deciency, Diabetes, and Obesity. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2019; 13(2): 1457-1461.

[135] - Von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D decient - a randomised, placebo-controlled trial. Br J Nutr. 2010; 103(4): 549–55.

[136] - Franceschi C, Capri M, Monti D, et al. Inammaging and anti-inammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128(1): 92–105.

[137] - Franceschi C, Bonafé M, Valensin S, et al. Inamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000; 908: 244–254.

[138] - Gonçalves de Carvalho CM, Ribeiro SM. Aging, low-grade systemic inammation and vitamin D: a mini-review. Eur J Clin Nutr 2017; 71(4): 434-440.

[139] - Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007; 167(16): 1730–1737.

[140] - Urruticoechea-Arana A, Martin-Martinez MA, Castaneda S, et al. Vitamin D deciency in chronic inammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study. Arthritis Res Ther 2015; 17: 211.

[141] - Binkley N. Does low vitamin D status contribute to “age-related” morbidity? J Bone Miner Res 2007; 22(S2): V55–V58.

[142] - Llewellyn DJ. Lang IA, Langa KM, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010; 170(13); 1135-41.

[143] - Annweiler C, Beauchet O. Questioning vitamin D status of elderly fallers and nonfallers; a meta-analysis to address a “forgotten step”. J Intern Med. 2015; 277(1); 16-44.

[144] - Verlaan S, Maier AB, Bauer JM, et al. Sucient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study. Clin Nutr. 2018;37(2): 551-557.

[145] - El-Hajj Fuleihan G, Baddoura R, Habib RH, et al. Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial. Am J Clin Nutr. 2016; 104 (2): 315-323.

[146] - Daniel Owens, Richard Allison y Graeme Close; Vitamin D and the Athletes: Current Perspectives and New Challenges. Sports Med 2018; 48 (1): 3-16

[147] - Dana Ogan and Kelly Pritchett. Vitamin D and the Athlete: Risk, Recommendations and Benets. Nutrients 2013; 5: 1856-1868

[148] - Constantini NW et al. High prevalence of vitamin D insuciency in athletes and dancers. Clin J Sport Med 2010; 20(5): 368-371

[149] - Lovell G. Vitamin D status of female in an elite gymnastics program. Clin J Sports Med. 2008; 18(2): 159-161

[150] - Michael Angeline, Albert Gee, Michael Shindle, Russel Warren and Scott Rodeo. The Effects of Vitamin D Deciency in Athletes. The American Journal of Sports Medicine 2013; 41(2): 461-464

[151] - Micah Dunn, Jacalyn Robert-McComb. Vitamin D Deciency in College-Age Male Basketabll Players: Sports Medicien Physicians Can Play an Important Role; International Journal of Research Studies in Medical and Health Sciences, 2017; 2(6): 8-15

[152] - Dylan Dahlquist, Brad Dieter and Michael Kowhle; Pausible ergogenic effects of vitamin D on athletic performance and recovery. J. Int Soc of Sport Nutr. 2015; 12: 33

Cover image

Abstract

Downloads

References

Keywords

Licencia