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A 19 year old male from the province of Los Santos, Panama; under study for generalized seizures for which he received lamotrigine during three weeks, presented with a seven-day history of evolution of general malaise, adynamia, unregulated fever without hourly predominance, bilateral conjunctivitis and progressive development of generalized erythema and purpuric macules, with initial predominance on the face, neck, trunk and proximal upper extremities in addition to generalized pruritus and skin sensitivity. During hospitalization the lesions disseminated to the rest of the body surface accompanied by blisters with clear content, areas of epidermal detachment and mucosal involvement, which initially covered less than 10% of the total body surface area with rapid progression to more than 80% in less than 24 hours. He was transferred to the Intensive Care Unit where he received systemic antibiotics, corticosteroids, and intravenous immunoglobulin with a favorable outcome.
