Criobiopsia como método diagnóstico de neumonía por Pneumocystis jirovecii

Yurielis Ramos Rodríguez; Elsa Rueda Borrero

Submitted October 30, 2024

Published 2026-02-02

Artículos de Investigación

Vol. 34 No. 1 (2021): Revista Médico Científica

Cryobiopsy as a diagnostic method for Pneumocystis jiroveciipneumonia

Yurielis Ramos Rodríguez⁺⁻
Elsa Rueda Borrero⁺⁻

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DOI: ND

Published: 2026-02-02

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

This is the case of a 57-year-old male with recently diagnosed HIV, a health care worker with 1-month history of weight loss and respiratory symptoms. Cryobiopsy is performed to isolate Pneumocystisin a histopathological sample. Cryobiopsy is a relativelynew method that allows the obtention of larger samples, thus increasing the diagnostic sensitivity to 95-100% in indeterminate interstitial lung disease.

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References

ONU SIDA. AIDSinfo Compare Data [Internet]. 2018. Disponible en: http://aidsinfo.unaids.org/.
ONU SIDA. Country factsheets: PANAMA [Internet]. 2018. Disponible en: https://www.unaids.org/es/regionscountries/countries/panama.
Catherinot E et al. Pneumocystis jirovecii pneumonia. Infect Dis Clin N Am 2010; 24:107–138.
Lewis White P. Diagnosis and management of Pneumocystis jirovecii infection. Expert Review of Anti-infective therapy 2017; 15(5):435-447.
Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-infected Adults and Adolescents: Recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. 2019. Disponible en: http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf.
Chaudhary S et al. Percutaneous transthoracic needle aspiration of the lung. Am J Dis Child 1977; 131:902-7.
Rodiño J et al. Diagnóstico microscópico de neumonía por Pneumocystis jirovecii en muestras de lavado broncoalveolar y lavado orofaríngeo de pacientes inmunocomprometidos con neumonía. Biomedica 2011; 31:222-31.
Griffiths MH et al. Diagnosis of pulmonary disease in human immunodeficiency virus infection: role of transbronchial biopsy and brochoalveolar lavage. Thorax 1989; 44:554-558.
Baughman R. Use of bronchoscopy in the diagnosis of infection in the immunocompromised host. Thorax 1994; 49:3-7.
Sánchez-Cabral O et al. Utility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases. Respiration 2017; 94:285–292.
Barisione E. Competence in transbronchial cryobiopsy. Panminerva Med 2019; 61:290-7.
Hernández-González F et al. Utilidad de la criobiopsia en el diagnóstico de la enfermedad pulmonar intersticial difusa: análisis de rentabilidad y coste. Arch Bronconeumol. 2015; 51(6):261–267.
Chen A et al. Cryobiopsy: A Work in Progress. Ann Am ThoracSoc 2017; 14(6):827-8.
Tomasetti S et al. Bronchoscopic Lung Cryobiopsy Increases Diagnostic Confidence in the Multidisciplinary Diagnosis of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016; 193(7):745–752.
Lodhi T et al. Transbronchial Lung Cryobiopsy in Idiopathic Pulmonary Fibrosis: A State of the Art Review. Adv Ther. 2019; 36:2193–220.

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[1] ONU SIDA. AIDSinfo Compare Data [Internet]. 2018. Disponible en: http://aidsinfo.unaids.org/.

[2] ONU SIDA. Country factsheets: PANAMA [Internet]. 2018. Disponible en: https://www.unaids.org/es/regionscountries/countries/panama.

[3] Catherinot E et al. Pneumocystis jirovecii pneumonia. Infect Dis Clin N Am 2010; 24:107–138.

[4] Lewis White P. Diagnosis and management of Pneumocystis jirovecii infection. Expert Review of Anti-infective therapy 2017; 15(5):435-447.

[5] Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-infected Adults and Adolescents: Recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. 2019. Disponible en: http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf.

[6] Chaudhary S et al. Percutaneous transthoracic needle aspiration of the lung. Am J Dis Child 1977; 131:902-7.

[7] Rodiño J et al. Diagnóstico microscópico de neumonía por Pneumocystis jirovecii en muestras de lavado broncoalveolar y lavado orofaríngeo de pacientes inmunocomprometidos con neumonía. Biomedica 2011; 31:222-31.

[8] Griffiths MH et al. Diagnosis of pulmonary disease in human immunodeficiency virus infection: role of transbronchial biopsy and brochoalveolar lavage. Thorax 1989; 44:554-558.

[9] Baughman R. Use of bronchoscopy in the diagnosis of infection in the immunocompromised host. Thorax 1994; 49:3-7.

[10] Sánchez-Cabral O et al. Utility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases. Respiration 2017; 94:285–292.

[11] Barisione E. Competence in transbronchial cryobiopsy. Panminerva Med 2019; 61:290-7.

[12] Hernández-González F et al. Utilidad de la criobiopsia en el diagnóstico de la enfermedad pulmonar intersticial difusa: análisis de rentabilidad y coste. Arch Bronconeumol. 2015; 51(6):261–267.

[13] Chen A et al. Cryobiopsy: A Work in Progress. Ann Am ThoracSoc 2017; 14(6):827-8.

[14] Tomasetti S et al. Bronchoscopic Lung Cryobiopsy Increases Diagnostic Confidence in the Multidisciplinary Diagnosis of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016; 193(7):745–752.

[15] Lodhi T et al. Transbronchial Lung Cryobiopsy in Idiopathic Pulmonary Fibrosis: A State of the Art Review. Adv Ther. 2019; 36:2193–220.

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