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We present the case of a 38-year-old female patient under observation by the Gastroenterology service since the beginning of September 2019, which reveals intra and extrahepatic bile duct dilation conditioned by gallstones in the middle third of the commonbile duct, as well as an overdistended gallbladder with four calculi inside. Endoscopic retrograde cholangiopancreatography (ERCP)was performed on two occasions, with suspicion of Mirizzi syndrome type II, partial cholecystectomy was performed with the extraction of several stones, one of them was nailed in the cystic duct conditioning communication with the bile duct, an intraoperative cholangiography results in a stone in the distal bile duct, which is why the open exploration was performed and the stone was extracted; later, a Kher tube was left in the bile duct and a final cholangiography was performed through it. Mirizzi syndrome was first described by Pablo Mirizzi in 1947 and the etiological factors of extrahepatic cholestasis in some patients with gallbladder lithiasis. 1 This pathology is rare worldwide.