This article analyzes the novel Lost Towns by Gil Blas Tejeira, focusing on its narrative, symbolism, its theme and its relationship with the history of Panama. Regarding its methodology, this research can be classified as qualitative, documentary and literary, where different types of documents are collected and analyzed, citing previous studies and research. The article highlights several aspects of the novel, including the history of Phoenix City (Columbus) and the construction of the Panama Canal. The main character, Pedro Prestán, curses the city before dying, but forgives his executioners and waits for time to reveal his role in the story. The Lost Towns of the title refer to the towns buried by the construction of the Canal, due to the lock system used by the United States. The American presence in the Canal contributed to the separation of Panama from Colombia and had a significant impact on migration, cultural diversity, and social conditions in the city of Colón. The novel highlights the geographical importance of Panama as a historical transit point and its role in the construction of the Canal, as well as the celebration of religious festivities and the attitude towards the American presence in the country. In Lost Towns part of the history and national identity of Panama is revealed, portraying historical events and prominent figures in the development of the country. The work is also praised for its literary value, its narrative style and its apocalyptic theme, where history and fiction are combined to offer a unique vision of the country's past. Its reading is recommended for those interested in knowing the history of Panama and its representation in literature.