MECANISMOS MOLECULARES INVOLUCRADOS EN LA DIFERENCIACIÓN DE CÉLULAS MADRE EN LINAJES GLIALES

José Antonio  Thomas Argüelles; Diego  Reginensi; L. Sebastián A Valerio

doi:10.48204/j.tecno.v25n2.a4070

Enviado julio 21, 2023

Publicado 2023-07-21

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Vol. 25 Núm. 2 (2023): Tecnociencia

MECANISMOS MOLECULARES INVOLUCRADOS EN LA DIFERENCIACIÓN DE CÉLULAS MADRE EN LINAJES GLIALES

José Antonio Thomas Argüelles ⁺⁻
Diego Reginensi ⁺⁻
L. Sebastián A Valerio ⁺⁻

DOI https://doi.org/10.48204/j.tecno.v25n2.a4070

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DOI: 10.48204/j.tecno.v25n2.a4070

Publicado: 2023-07-21

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Thomas Argüelles , J. A., Reginensi , D. y A Valerio , L. S. (2023) «MECANISMOS MOLECULARES INVOLUCRADOS EN LA DIFERENCIACIÓN DE CÉLULAS MADRE EN LINAJES GLIALES», Tecnociencia, 25(2), pp. 138–168. doi: 10.48204/j.tecno.v25n2.a4070.

Derechos de autor 2023 Tecnociencia

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.

Resumen

A pesar del hecho que diferentes tipos de células tienen diferentes funciones y morfologías, todas descienden de una célula ancestral común, conocidas también como células madre, por lo que esencialmente comparten el mismo ADN. Lo que las diferencia es la dinámica molecular, lo cual implica regular modificaciones químicas en el microambiente interno de las células con el fin de modular el nicho de un tejido o un órgano. Uno de los principales objetivos de este artículo de revisión, es recapitular el desarrollo normal del organismo y como se puede aprovechar la capacidad regenerativa endógena de las células madre. Este articulo define los conceptos claves en biología de células madre con respecto al sistema nervioso, presenta una descripción general del desarrollo de las células oligodendrociticas y su importancia en el desarrollo de la mielinización, el cual requiere un modelo experimental en el que los axones neuronales y los oligodendrocitos se puedan controlar y manipular durante el proceso.

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