MECANISMOS MOLECULARES INVOLUCRADOS EN LA DIFERENCIACIÓN DE CÉLULAS MADRE EN LINAJES GLIALES

José Antonio  Thomas Argüelles; Diego  Reginensi; L. Sebastián A Valerio

doi:10.48204/j.tecno.v25n2.a4070

Submitted July 21, 2023

Published 2023-07-21

Artículos

Vol. 25 No. 2 (2023): Tecnociencia

MOLECULAR MECHANISMS INVOLVED IN THE DIFFERENTIATION OF STEM CELLS INTO GLIAL LINEAGES

José Antonio Thomas Argüelles ⁺⁻
Diego Reginensi ⁺⁻
L. Sebastián A Valerio ⁺⁻

DOI https://doi.org/10.48204/j.tecno.v25n2.a4070

PDF (Español (España))

References

DOI: 10.48204/j.tecno.v25n2.a4070

Published: 2023-07-21

How to Cite

Thomas Argüelles , J. A., Reginensi , D. and A Valerio , L. S. (2023) “MOLECULAR MECHANISMS INVOLVED IN THE DIFFERENTIATION OF STEM CELLS INTO GLIAL LINEAGES”, Tecnociencia, 25(2), pp. 138–168. doi: 10.48204/j.tecno.v25n2.a4070.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

Even though different cell types have different functions and morphologies, they are all descended from a common ancestral cell, also known as stem cells, so they essentially share the same DNA. What differentiates them is molecular dynamics, which involves regulating chemical modifications in the internal microenvironment of cells to modulate the niche of a tissue or organ. One of the main objectives of this review article is to recapitulate the normal development of the organism and how the endogenous regenerative capacity of stem cells can be harnessed. This article defines the key concepts in stem cell biology with respect to the nervous system, presents an overview of oligodendrocyte cell development and its importance in the development of myelination, which requires an experimental model in which neuronal axons and oligodendrocytes can be controlled and manipulated during the process.

Downloads

Download data is not yet available.

References

Aiba, T., Saito, T., Hayashi, A., Sato, S., Yunokawa, H., Maruyama, T., Fujibuchi, W., Kurita, H., Tohyama, C., & Ohsako, S. (2017). Methylated site display (MSD)-AFLP, a sensitive & affordable method for analysis of CpG methylation profiles. BMC Molecular Biology, 18(1), 1–11. https://doi.org/10.1186/s12867-017-0083-2
Alam, P., Al-yousef, H. M., Siddiqui, N. A., Alhowiriny, T. A., Alqasoumi, S. I., Amina, M., Hassan, W., Hassan, B., Abdelaziz, S., & Abdalla, R. H. (2018). Anticancer activity and concurrent analysis of ursolic acid , b -sitosterol and lupeol in three different Hibiscus species ( aerial parts ) by validated HPTLC method. Saudi Pharmaceutical Journal, 26(7), 1060–1067.
https://doi.org/10.1016/j.jsps.2018.05.015
Almalki, S. G., & Agrawal, D. K. (2017). Key Transcription Factors in the Differentiation of Mesenchymal Stem Cells. Physiology & Behavior, 176(10), 139–148. https://doi.org/10.1016/j.diff.2016.02.005.Key
Baker, C. L., & Pera, M. F. (2018). Capturing Totipotent Stem Cells. Cell Stem Cell, 22(1), 25–34. https://doi.org/10.1016/j.stem.2017.12.011
Baldassarro, V. A., Giardino, L., & Calzà, L. (2021). Oligodendrocytes in a dish for the drug discovery pipeline?: the risk of oversimplification. 16(2), 291–293.
Ballabeni, A., Park, I. H., Zhao, R., Wang, W., Lerou, P. H., Daley, G. Q., and Kirschner, M. W. (2011). Cell cycle adaptations of embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 108(48), 19252–19257. https://doi.org/10.1073/pnas.1116794108
Barros, C. S., Franco, S. J., Müller, U., Lu, P., Takai, K., Weaver, V. M., Hynes, R. O., Naba, A., Huttenlocher, A., Horwitz, A. R., Geiger, B., Yamada, K. M., Adams, J. C., Lawler, J., Munger, J. S., & Sheppard, D. (2014). Extracellular Matrix?: Functions in the Nervous System. Cold Spring Harbor Perspectives in Biology, 1(25). https://doi.org/10.1101/cshperspect.a005108
Boroviak, T., Loos, R., Bertone, P., Smith, A., & Nichols, J. (2014). The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nature Cell Biology, 16(6), 513–525. https://doi.org/10.1038/ncb2965
Boyer, M. J., & Cheng, T. (2008). The CDK inhibitors: Potential targets for therapeutic stem cell manipulations? Gene Therapy, 15(2), 117–125. https://doi.org/10.1038/sj.gt.3303064
Breton, J. M., Long, K. L. P., Barraza, M. K., Perloff, O. S., & Kaufer, D. (2021). Hormonal regulation of oligodendrogenesis II: Implications for myelin repair. Biomolecules, 11(2), 1–26. https://doi.org/10.3390/biom11020290
Buechler, J., & Salinas, P. C. (2018). Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor. Frontiers in Synaptic Neuroscience, 10(October), 1–10. https://doi.org/10.3389/fnsyn.2018.00038
Casser, E., Israel, S., Schlatt, S., Nordhoff, V., & Boiani, M. (2018). Retrospective analysis: Reproducibility of interblastomere differences of mRNA expression in 2-cell stage mouse embryos is remarkably poor due to combinatorial mechanisms of blastomere diversification. Molecular Human Reproduction, 24(7), 388–400. https://doi.org/10.1093/molehr/gay021
Casser, E., Israel, S., Witten, A., Schulte, K., Schlatt, S., Nordhoff, V., and Boiani, M. (2017). Totipotency segregates between the sister blastomeres of two-cell stage mouse embryos. Scientific Reports, 7(1), 1–15. https://doi.org/10.1038/s41598-017-08266-6
Cheng, T., & Scadden, D. T. (2014). Cell Cycle Regulators in Stem Cells. In Essentials of Stem Cell Biology: Third Edition (Third Edit). Elsevier Inc. https://doi.org/10.1016/B978-0-12-409503-8.00008-1
Chien, C. (2011). Neural Stem Cell Markers?: Cytoskeletons. Medicine.
Cho, I. K., Hunter, C. E., Ye, S., Pongos, A. L., & Chan, A. W. S. (2019). Combination of stem cell and gene therapy ameliorates symptoms in Huntington’s disease mice. Npj Regenerative Medicine, 4(1), 1–9. https://doi.org/10.1038/s41536-019-0066-7
Christians, E. S. (2016). Totipotency continuity from zygote to early blastomeres: a model under revision Michele.
Dey, D., & Evans, G. R. D. (2011). Generation of induced pluripotent stem (iPS) cells by nuclear reprogramming. Stem Cells International, 2011(c). https://doi.org/10.4061/2011/619583
Ding, L., Cao, J., Lin, W., Chen, H., Xiong, X., Ao, H., Yu, M., Lin, J., and Cui, Q. (2020). The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer. In International Journal of Molecular Sciences (Vol. 21, Issue 6, pp. 1–28). https://doi.org/10.3390/ijms21061960
El-Badawy, A., & El-Badri, N. (2016). The cell cycle as a brake for ?-cell regeneration from embryonic stem cells. In Stem Cell Research and Therapy (Vol. 7, Issue 1, pp. 1–9). Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-015-0274-z
Ferreira, A. F., Calin, G. A., Picanço-Castro, V., Kashima, S., Covas, D. T., & de Castro, F. A. (2018). Hematopoietic stem cells from induced pluripotent stem cells - Considering the role of microRNA as a cell differentiation regulator. Journal of Cell Science, 131(4). https://doi.org/10.1242/jcs.203018
Fogarty, N. M. E., McCarthy, A., Snijders, K. E., Powell, B. E., Kubikova, N., Blakeley, P., Lea, R., Elder, K., Wamaitha, S. E., Kim, D., Maciulyte, V., Kleinjung, J., Kim, J. S., Wells, D., Vallier, L., Bertero, A., Turner, J. M. A., & Niakan, K. K. (2017). Genome editing reveals a role for OCT4 in human embryogenesis. Nature, 550(7674), 67–73. https://doi.org/10.1038/nature24033
George, S. K., Abolbashari, M., Kim, T.-H., Zhang, C., Allickson, J., Jackson, J. D., Lee, S. J., Ko, I. K., Atala, A., & Yoo, J. J. (2019). Effect of Human Amniotic Fluid Stem Cells on Kidney Function in a Model of Chronic Kidney Disease. Tissue Engineering Part A, 1–28. https://doi.org/10.1089/ten.tea.2018.0371
Grochowski, C., Radzikowska, E., & Maciejewski, R. (2018). Neural stem cell therapy—Brief review. Clinical Neurology and Neurosurgery, 173, 8–14. https://doi.org/10.1016/j.clineuro.2018.07.013
Gudi, V., Škuljec, J., Yildiz, Ö., Frichert, K., Skripuletz, T., Moharregh-Khiabani, D., Voß, E., Wissel, K., Wolter, S., & Stangel, M. (2011). Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming. PLoS ONE, 6(7). https://doi.org/10.1371/journal.pone.0022623
Guerra, P., Valbuena, A., Querol-Audí, J., Silva, C., Castellanos, M., Rodríguez-Huete, A., Garriga, D., Mateu, M. G., & Verdaguer, N. (2017). Structural basis for biologically relevant mechanical stiffening of a virus capsid by cavity-creating or spacefilling mutations. Scientific Reports, 7(1), 1–13. https://doi.org/10.1038/s41598-017-04345-w
Gupta, N., Henry, R. G., Strober, J., Kang, S. M., Lim, D. A., Bucci, M., Caverzasi, E., Gaetano, L., Mandelli, M. L., Ryan, T., Perry, R., Farrell, J., Jeremy, R. J., Ulman, M., Huhn, S. L., Barkovich, A. J., & Rowitch, D. H. (2012). Neural stem cell engraftment and myelination in the human brain. Science Translational Medicine, 4(155). https://doi.org/10.1126/scitranslmed.3004373
Harrison, S. E., Sozen, B., Christodoulou, N., Kyprianou, C., & Zernicka-Goetz, M. (2017). Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science, 356(6334). https://doi.org/10.1126/science.aal1810
Hester, E. M., & Hood, B. A. (2017). Stem Cell Technologies in Neuroscience. In Cryopreservation, Standardized (Vol. 126, pp. 193–203). https://doi.org/10.1007/978-1-4939-7024-7
Hogg, K., Etherington, S. L., Young, J. M., Mcneilly, A. S., & Colin, W. (2010). Hogg 2010 Inhibitor of Differentiation (Id) genes are expressed in the.pdf. 151(3), 1247–1256. https://doi.org/10.1210/en.2009-0914.Inhibitor
Izrael, M., Zhang, P., Kaufman, R., Shinder, V., Ella, R., Amit, M., Itskovitz-eldor, J., Chebath, J., & Revel, M. (2007). Human oligodendrocytes derived from embryonic stem cells?: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. 34, 310–323. https://doi.org/10.1016/j.mcn.2006.11.008
Jin, Y. R., Han, X. H., Nishimori, K., Ben-Avraham, D., Oh, Y. J., Shim, J. W., & Yoon, J. K. (2020). Canonical WNT/?-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice. Frontiers in Cell and Developmental Biology, 8(May), 1–16. https://doi.org/10.3389/fcell.2020.00264
Kanton, S., Boyle, M. J., He, Z., Santel, M., Weigert, A., Sanchís-Calleja, F., Guijarro, P., Sidow, L., Fleck, J. S., Han, D., Qian, Z., Heide, M., Huttner, W. B., Khaitovich, P., Pääbo, S., Treutlein, B., & Camp, J. G. (2019). Organoid single-cell genomic atlas uncovers human-specific features of brain development. In Nature (Vol. 574, Issue 7778). https://doi.org/10.1038/s41586-019-1654-9
Kashyap, V., Rezende, N. C., Scotland, K. B., Shaffer, S. M., Persson, J. L., Gudas, L. J., and Mongan, N. P. (2009). Regulation of Stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog, OCT4, and SOX2 pluripotency transcription factors with polycomb Repressive Complexes and Stem Cell microRNAs. Stem Cells and Development, 18(7), 1093–1108. https://doi.org/10.1089/scd.2009.0113
Kraushaar, D. C., & Zhao, K. (2013). The epigenomics of embryonic stem cell differentiation. International Journal of Biological Sciences, 9(10), 1134–1144. https://doi.org/10.7150/ijbs.7998
Lara Vellosillo. (2015). Diferenciación de las células estromales de tejido adiposo de rata para la obtención de células con fenotipo Oligodendroglial.
Lee, J., Rabbani, C. C., Gao, H., Steinhart, M. R., Woodruff, B. M., Pflum, Z. E., Kim, A., Heller, S., Liu, Y., Shipchandler, T. Z., & Koehler, K. R. (2020). Hair-bearing human skin generated entirely from pluripotent stem cells. Nature, 582(7812), 399–404. https://doi.org/10.1038/s41586-020-2352-3
Lee, M. B., & Kaeberlein, M. (2018). Translational Geroscience: From invertebrate models to companion animal and human interventions. Translational Medicine of Aging, 2, 15–29. https://doi.org/10.1016/j.tma.2018.08.002
Li, M., & Izpisua Belmonte, J. C. (2018). Deconstructing the pluripotency gene regulatory network. Nature Cell Biology, 20(4), 382–392. https://doi.org/10.1038/s41556-018-0067-6
Liang, R., & Liu, Y. (2018). Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells. Stem Cell Research & Therapy, 9(1), 1–7. https://doi.org/10.1186/s13287-018-1015-x
Liu, L., Michowski, W., Kolodziejczyk, A., & Sicinski, P. (2019). The cell cycle in stem cell proliferation, pluripotency and differentiation. Nature Cell Biology, 21(9), 1060–1067. https://doi.org/10.1038/s41556-019-0384-4
Lodish, Berk, Kaiser, Krieger, Bretscher, & Ploegh. (2018). Molecular Cell Biology. https://doi.org/http://pubs.acs.org/doi/pdf/ 10.1021/ ja309527h.
Long, K. L. P., Breton, J. M., Barraza, M. K., Perloff, O. S., & Kaufer, D. (2021). Hormonal regulation of oligodendrogenesis i: Effects across the lifespan. Biomolecules, 11(2), 1–36. https://doi.org/10.3390/ biom11020283
McPhie, D. L., Nehme, R., Ravichandran, C., Babb, S. M., Ghosh, S. D., Staskus, A., Kalinowski, A., Kaur, R., Douvaras, P., Du, F., Ongur, D., Fossati, V., Eggan, K., & Cohen, B. M. (2018). Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Translational Psychiatry, 8(1). https://doi.org/10.1038/s41398-018-0284-6
Méndez-Maldonado, K., Vega-López, G. A., Aybar, M. J., and Velasco, I. (2020). Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia. Frontiers in Cell and Developmental Biology, 8 (August). https://doi.org/10.3389/fcell.2020.00635
Mercurio, S., Serra, L., & Nicolis, S. K. (2019). More than just stem cells: Functional roles of the transcription factor Sox2 in differentiated glia and neurons. International Journal of Molecular Sciences, 20(18). https://doi.org/10.3390/ijms20184540
Mistri, T. K., Kelly, D., Mak, J., Colby, D., Mullin, N., andChambers, I. (2020). Characterisation of interactions between the pluripotency transcription factors Nanog, Oct4 and Sox2. https://doi.org/10.1101/2020.06.24.169185
Miyamoto, N., & Wada, H. (2013). Hemichordate neurulation and the origin of the neural tube. Nature Communications, 4. https://doi.org/10.1038/ncomms3713
Moreno, C. L., & Mobbs, C. V. (2017). Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet. Molecular and Cellular Endocrinology, 455, 33–40. https://doi.org/10.1016/j.mce.2016.11.013
Moris, N., Pina, C., & Arias, A. M. (2016). Transition states and cell fate decisions in epigenetic landscapes. Nature Reviews Genetics, 17(11), 693–703. https://doi.org/10.1038/nrg.2016.98
Mossahebi-Mohammadi, M., Quan, M., Zhang, J. S., & Li, X. (2020). FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency. Frontiers in Cell and Developmental Biology, 8(February), 1–10. https://doi.org/10.3389/fcell.2020.00079
Murphy, M., Chatterjee, S. S., Jain, S., Katari, M., & Dasgupta, R. (2016). TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. Scientific Reports, 6(June), 1–12. https://doi.org/10.1038/srep28299
Nandi, P., Lim, H., Torres-Garcia, E. J., & Lala, P. K. (2018). Human trophoblast stem cell self-renewal and differentiation: Role of decorin. Scientific Reports, 8(1), 1–14. https://doi.org/10.1038/s41598-018-27119-4
Niwa, H., Nakamura, A., Urata, M., Shirae-Kurabayashi, M., Kuraku, S., Russell, S., & Ohtsuka, S. (2016). The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells. BMC Evolutionary Biology, 16(1), 1–12. https://doi.org/10.1186/s12862-016-0755-4
Noh, H., Shao, Z., Coyle, J. T., & Chung, S. (2017). BBA - Molecular Basis of Disease Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells ( iPSCs ). BBA - Molecular Basis of Disease, 1863(9), 2382–2387. https://doi.org/10.1016/ j.bbadis.2017.06.019
Pan, G. J., Chang, Z. Y. I., Schöler, H. R., & Pei, D. (2002). Stem cell pluripotency and transcription factor Oct4. Cell Research, 12(5–6), 321–329. https://doi.org/10.1038/sj.cr.7290134
Pandima Devi, K., Rajavel, T., Daglia, M., Nabavi, S. F., Bishayee, A., and Nabavi, S. M. (2017). Targeting miRNAs by polyphenols: Novel therapeutic strategy for cancer. Seminars in Cancer Biology, 46, 146–157. https://doi.org/10.1016/j.semcancer.2017.02.001
Perlman, K., Couturier, C. P., Yaqubi, M., Tanti, A., Cui, Q. L., Pernin, F., Stratton, J. A., Ragoussis, J., Healy, L., Petrecca, K., Dudley, R., Srour, M., Hall, J. A., Kennedy, T. E., Mechawar, N., & Antel, J. P. (2020). Developmental trajectory of oligodendrocyte progenitor cells in the human brain revealed by single cell RNA sequencing. GLIA, 68(6), 1291–1303. https://doi.org/10.1002/glia.23777
Pimentel-Parra, G. A., & Murcia-Ordoñez, B. (2017). Células madre, una nueva alternativa médica. Perinatología y Reproducción Humana, 31(1), 28–33. https://doi.org/10.1016/j.rprh.2017.10.013
Ramalho-Santos, M., & Willenbring, H. (2007). On the Origin of the Term “Stem Cell.” Cell Stem Cell, 1(1), 35–38. https://doi.org/10.1016/j.stem.2007.05.013
Rasband, M. N., & Peles, E. (2015). The Nodes of Ranvier?: Molecular Assembly and Maintenance. 1–16.
Rathnam, C., Chueng, S. T. D., Yang, L., & Lee, K. B. (2017). Advanced gene manipulation methods for stem cell theranostics. Theranostics, 7(11), 2775–2793. https://doi.org/10.7150/thno.19443
Rieckher, M., Markaki, M., Princz, A., Schumacher, B., & Tavernarakis, N. (2018). Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans. Cell Reports, 25(1), 199-211.e6. https://doi.org/10.1016/j.celrep.2018.09.009
Rivron, N. C., Frias-Aldeguer, J., Vrij, E. J., Boisset, J. C., Korving, J., Vivié, J., Truckenmüller, R. K., Van Oudenaarden, A., Van Blitterswijk, C. A., & Geijsen, N. (2018). Blastocyst-like structures generated solely from stem cells. Nature, 557(7703), 106–111. https://doi.org/10.1038/s41586-018-0051-0
Savatier, P., & Malashicheva, A. (2004). Cell-Cycle Control in Embryonic Stem Cells. In Handbook of Stem Cells (Vol. 1). Elsevier Inc. https://doi.org/10.1016/B978-012436643-5/50014-6
Sedaghat, F., Cheraghpour, M., Hosseini, S. A., Pourvali, K., Teimoori-Toolabi, L., Mehrtash, A., Talaei, R., & Zand, H. (2019). Hypomethylation of NANOG promoter in colonic mucosal cells of obese patients: A possible role of NF-?B. British Journal of Nutrition, 122(5), 499–508. https://doi.org/10.1017/S000711451800212X
Senft, A. D., Bikoff, E. K., Robertson, E. J., & Costello, I. (2019).
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse. Nature Communications, 10(1), 1–11. https://doi.org/10.1038/s41467-019-09052-w
Sharma, S., & Bhonde, R. (2020). Genetic and epigenetic stability of stem cells: Epigenetic modifiers modulate the fate of mesenchymal stem cells. Genomics, 112(5), 3615–3623. https://doi.org/10.1016/ j.ygeno.2020.04.022
Shi, J., Shi, W., Ni, L., Xu, X., Su, X., Xia, L., Xu, F., Chen, J., & Zhu, J. (2013). OCT4 is epigenetically regulated by DNA hypomethylation of promoter and exon in primary gliomas. Oncology Reports, 30(1), 201–206. https://doi.org/10.3892/or.2013.2456
Smith, L. R., Cho, S., & Discher, D. E. (2018). Stem cell differentiation is regulated by extracellular matrix mechanics. Physiology, 33(1), 16–25. https://doi.org/10.1152/physiol.00026.2017
Son, J., Tae, J.-Y., Min, S., Ko, Y., & Park, J.-B. (2020). Fibroblast growth factor-4 maintains cellular viability while enhancing osteogenic differentiation of stem cell spheroids in part by regulating RUNX2 and BGLAP expression. Experimental and Therapeutic Medicine, 2013–2020. https://doi.org/10.3892/etm.2020.8951
Song, I., & Dityatev, A. (2018). Crosstalk between glia, extracellular matrix and neurons. Brain Research Bulletin, 136, 101–108. https://doi.org/10.1016/j.brainresbull.2017.03.003
Steinhart, Z., & Angers, S. (2018). Wnt signaling in development and tissue homeostasis. Development (Cambridge, England), 145(11), 1–8. https://doi.org/10.1242/dev.146589
Taupin, P. (2010). Very small embryonic-like stem cells for regenerative medicine: WO2010039241. Expert Opinion on Therapeutic Patents, 20(8), 1103–1106. https://doi.org/10.1517/13543776.2010.495122
Tremble, K., Stirparo, G. G., Bates, L. E., Maskalenka, K., Stuart, H. T., Jones, K., Andersson-Rolf, A., Radzisheuskaya, A., Koo, B. K., Bertone, P., and Silva, J. C. R. (2020). Sox2 modulation increases naïve pluripotency plasticity. In bioRxiv. https://doi.org/10.1101/ 2020.01.14.906933
van Holde, K. E., & Zlatanova, J. (2018). Development and Differentiation. The Evolution of Molecular Biology, 135–147. https://doi.org/10.1016/b978-0-12-812917-3.00013-9
Verneri, P., Vazquez Echegaray, C., Oses, C., Stortz, M., Guberman, A., and Levi, V. (2020). Dynamical reorganization of the pluripotency transcription factors Oct4 and Sox2 during early differentiation of embryonic stem cells. Scientific Reports, 10(1), 1–12. https://doi.org/10.1038/s41598-020-62235-0
Wang, J., Rao, S., Chu, J., Shen, X., Levasseur, D. N., Theunissen, T. W., & Orkin, S. H. (2006). A protein interaction network for pluripotency of embryonic stem cells. Nature, 444(7117), 364–368. https://doi.org/10.1038/nature05284
Weider, M., Starost, L. J., Groll, K., Küspert, M., Sock, E., Wedel, M., Fröb, F., Schmitt, C., Baroti, T., Hartwig, A. C., Hillgärtner, S., Piefke, S., Fadler, T., Ehrlich, M., Ehlert, C., Stehling, M., Albrecht, S., Jabali, A., Schöler, H. R., … Wegner, M. (2018). Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nature Communications, 2018(MARCH), 1–16. https://doi.org/10.1038/s41467-018-03336-3
Xu, L., & Jiang, H. (2020). Writing and Reading Histone H3 Lysine 9 Methylation in Arabidopsis. In Frontiers in Plant Science (Vol. 11). https://doi.org/10.3389/fpls.2020.00452
Xu, Z., Robitaille, A. M., Berndt, J. D., Davidson, K. C., Fischer, K. A., Mathieu, J., Potter, J. C., Ruohola-Baker, H., & Moon, R. T. (2016).
Wnt/?-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 113(42), E6382–E6390. https://doi.org/10.1073/pnas.1613849113
York, J. R., & McCauley, D. W. (2020). The origin and evolution of vertebrate neural crest cells. Open Biology, 10(1). https://doi.org/10.1098/rsob.190285
Yunusova, A. M., Fishman, V. S., Vasiliev, G. V., & Battulin, N. R. (2017). Deterministic versus stochastic model of reprogramming: New evidence from cellular barcoding technique. Open Biology, 7(4). https://doi.org/10.1098/rsob.160311
Zakrzewski, W., Dobrzy?ski, M., Szymonowicz, M., & Rybak, Z. (2019). Stem cells: Past, present, and future. Stem Cell Research and Therapy, 10(1), 1–22. https://doi.org/10.1186/s13287-019-1165-5
Zaveri, L., & Dhawan, J. (2018). Cycling to meet fate: Connecting pluripotency to the cell cycle. Frontiers in Cell and Developmental Biology, 6(JUN), 1–19. https://doi.org/10.3389/fcell.2018.00057
Zhang, H., Shao, X., Peng, Y., Teng, Y., Saravanan, K. M., Zhang, H., Li, H., and Wei, Y. (2019). A novel machine learning based approach for iPS progenitor cell identification. BioRxiv, 744920. https://doi.org/10.1101/744920

Keywords

PDF (Español (España))

Resumen visto - 386 veces
PDF (Español (España)) descargado - 307

Licencia

Este obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional.

Content Top

[1] Aiba, T., Saito, T., Hayashi, A., Sato, S., Yunokawa, H., Maruyama, T., Fujibuchi, W., Kurita, H., Tohyama, C., & Ohsako, S. (2017). Methylated site display (MSD)-AFLP, a sensitive & affordable method for analysis of CpG methylation profiles. BMC Molecular Biology, 18(1), 1–11. https://doi.org/10.1186/s12867-017-0083-2

[2] Alam, P., Al-yousef, H. M., Siddiqui, N. A., Alhowiriny, T. A., Alqasoumi, S. I., Amina, M., Hassan, W., Hassan, B., Abdelaziz, S., & Abdalla, R. H. (2018). Anticancer activity and concurrent analysis of ursolic acid , b -sitosterol and lupeol in three different Hibiscus species ( aerial parts ) by validated HPTLC method. Saudi Pharmaceutical Journal, 26(7), 1060–1067.

[3] https://doi.org/10.1016/j.jsps.2018.05.015

[4] Almalki, S. G., & Agrawal, D. K. (2017). Key Transcription Factors in the Differentiation of Mesenchymal Stem Cells. Physiology & Behavior, 176(10), 139–148. https://doi.org/10.1016/j.diff.2016.02.005.Key

[5] Baker, C. L., & Pera, M. F. (2018). Capturing Totipotent Stem Cells. Cell Stem Cell, 22(1), 25–34. https://doi.org/10.1016/j.stem.2017.12.011

[6] Baldassarro, V. A., Giardino, L., & Calzà, L. (2021). Oligodendrocytes in a dish for the drug discovery pipeline?: the risk of oversimplification. 16(2), 291–293.

[7] Ballabeni, A., Park, I. H., Zhao, R., Wang, W., Lerou, P. H., Daley, G. Q., and Kirschner, M. W. (2011). Cell cycle adaptations of embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 108(48), 19252–19257. https://doi.org/10.1073/pnas.1116794108

[8] Barros, C. S., Franco, S. J., Müller, U., Lu, P., Takai, K., Weaver, V. M., Hynes, R. O., Naba, A., Huttenlocher, A., Horwitz, A. R., Geiger, B., Yamada, K. M., Adams, J. C., Lawler, J., Munger, J. S., & Sheppard, D. (2014). Extracellular Matrix?: Functions in the Nervous System. Cold Spring Harbor Perspectives in Biology, 1(25). https://doi.org/10.1101/cshperspect.a005108

[9] Boroviak, T., Loos, R., Bertone, P., Smith, A., & Nichols, J. (2014). The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nature Cell Biology, 16(6), 513–525. https://doi.org/10.1038/ncb2965

[10] Boyer, M. J., & Cheng, T. (2008). The CDK inhibitors: Potential targets for therapeutic stem cell manipulations? Gene Therapy, 15(2), 117–125. https://doi.org/10.1038/sj.gt.3303064

[11] Breton, J. M., Long, K. L. P., Barraza, M. K., Perloff, O. S., & Kaufer, D. (2021). Hormonal regulation of oligodendrogenesis II: Implications for myelin repair. Biomolecules, 11(2), 1–26. https://doi.org/10.3390/biom11020290

[12] Buechler, J., & Salinas, P. C. (2018). Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor. Frontiers in Synaptic Neuroscience, 10(October), 1–10. https://doi.org/10.3389/fnsyn.2018.00038

[13] Casser, E., Israel, S., Schlatt, S., Nordhoff, V., & Boiani, M. (2018). Retrospective analysis: Reproducibility of interblastomere differences of mRNA expression in 2-cell stage mouse embryos is remarkably poor due to combinatorial mechanisms of blastomere diversification. Molecular Human Reproduction, 24(7), 388–400. https://doi.org/10.1093/molehr/gay021

[14] Casser, E., Israel, S., Witten, A., Schulte, K., Schlatt, S., Nordhoff, V., and Boiani, M. (2017). Totipotency segregates between the sister blastomeres of two-cell stage mouse embryos. Scientific Reports, 7(1), 1–15. https://doi.org/10.1038/s41598-017-08266-6

[15] Cheng, T., & Scadden, D. T. (2014). Cell Cycle Regulators in Stem Cells. In Essentials of Stem Cell Biology: Third Edition (Third Edit). Elsevier Inc. https://doi.org/10.1016/B978-0-12-409503-8.00008-1

[16] Chien, C. (2011). Neural Stem Cell Markers?: Cytoskeletons. Medicine.

[17] Cho, I. K., Hunter, C. E., Ye, S., Pongos, A. L., & Chan, A. W. S. (2019). Combination of stem cell and gene therapy ameliorates symptoms in Huntington’s disease mice. Npj Regenerative Medicine, 4(1), 1–9. https://doi.org/10.1038/s41536-019-0066-7

[18] Christians, E. S. (2016). Totipotency continuity from zygote to early blastomeres: a model under revision Michele.

[19] Dey, D., & Evans, G. R. D. (2011). Generation of induced pluripotent stem (iPS) cells by nuclear reprogramming. Stem Cells International, 2011(c). https://doi.org/10.4061/2011/619583

[20] Ding, L., Cao, J., Lin, W., Chen, H., Xiong, X., Ao, H., Yu, M., Lin, J., and Cui, Q. (2020). The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer. In International Journal of Molecular Sciences (Vol. 21, Issue 6, pp. 1–28). https://doi.org/10.3390/ijms21061960

[21] El-Badawy, A., & El-Badri, N. (2016). The cell cycle as a brake for ?-cell regeneration from embryonic stem cells. In Stem Cell Research and Therapy (Vol. 7, Issue 1, pp. 1–9). Stem Cell Research & Therapy. https://doi.org/10.1186/s13287-015-0274-z

[22] Ferreira, A. F., Calin, G. A., Picanço-Castro, V., Kashima, S., Covas, D. T., & de Castro, F. A. (2018). Hematopoietic stem cells from induced pluripotent stem cells - Considering the role of microRNA as a cell differentiation regulator. Journal of Cell Science, 131(4). https://doi.org/10.1242/jcs.203018

[23] Fogarty, N. M. E., McCarthy, A., Snijders, K. E., Powell, B. E., Kubikova, N., Blakeley, P., Lea, R., Elder, K., Wamaitha, S. E., Kim, D., Maciulyte, V., Kleinjung, J., Kim, J. S., Wells, D., Vallier, L., Bertero, A., Turner, J. M. A., & Niakan, K. K. (2017). Genome editing reveals a role for OCT4 in human embryogenesis. Nature, 550(7674), 67–73. https://doi.org/10.1038/nature24033

[24] George, S. K., Abolbashari, M., Kim, T.-H., Zhang, C., Allickson, J., Jackson, J. D., Lee, S. J., Ko, I. K., Atala, A., & Yoo, J. J. (2019). Effect of Human Amniotic Fluid Stem Cells on Kidney Function in a Model of Chronic Kidney Disease. Tissue Engineering Part A, 1–28. https://doi.org/10.1089/ten.tea.2018.0371

[25] Grochowski, C., Radzikowska, E., & Maciejewski, R. (2018). Neural stem cell therapy—Brief review. Clinical Neurology and Neurosurgery, 173, 8–14. https://doi.org/10.1016/j.clineuro.2018.07.013

[26] Gudi, V., Škuljec, J., Yildiz, Ö., Frichert, K., Skripuletz, T., Moharregh-Khiabani, D., Voß, E., Wissel, K., Wolter, S., & Stangel, M. (2011). Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming. PLoS ONE, 6(7). https://doi.org/10.1371/journal.pone.0022623

[27] Guerra, P., Valbuena, A., Querol-Audí, J., Silva, C., Castellanos, M., Rodríguez-Huete, A., Garriga, D., Mateu, M. G., & Verdaguer, N. (2017). Structural basis for biologically relevant mechanical stiffening of a virus capsid by cavity-creating or spacefilling mutations. Scientific Reports, 7(1), 1–13. https://doi.org/10.1038/s41598-017-04345-w

[28] Gupta, N., Henry, R. G., Strober, J., Kang, S. M., Lim, D. A., Bucci, M., Caverzasi, E., Gaetano, L., Mandelli, M. L., Ryan, T., Perry, R., Farrell, J., Jeremy, R. J., Ulman, M., Huhn, S. L., Barkovich, A. J., & Rowitch, D. H. (2012). Neural stem cell engraftment and myelination in the human brain. Science Translational Medicine, 4(155). https://doi.org/10.1126/scitranslmed.3004373

[29] Harrison, S. E., Sozen, B., Christodoulou, N., Kyprianou, C., & Zernicka-Goetz, M. (2017). Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science, 356(6334). https://doi.org/10.1126/science.aal1810

[30] Hester, E. M., & Hood, B. A. (2017). Stem Cell Technologies in Neuroscience. In Cryopreservation, Standardized (Vol. 126, pp. 193–203). https://doi.org/10.1007/978-1-4939-7024-7

[31] Hogg, K., Etherington, S. L., Young, J. M., Mcneilly, A. S., & Colin, W. (2010). Hogg 2010 Inhibitor of Differentiation (Id) genes are expressed in the.pdf. 151(3), 1247–1256. https://doi.org/10.1210/en.2009-0914.Inhibitor

[32] Izrael, M., Zhang, P., Kaufman, R., Shinder, V., Ella, R., Amit, M., Itskovitz-eldor, J., Chebath, J., & Revel, M. (2007). Human oligodendrocytes derived from embryonic stem cells?: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. 34, 310–323. https://doi.org/10.1016/j.mcn.2006.11.008

[33] Jin, Y. R., Han, X. H., Nishimori, K., Ben-Avraham, D., Oh, Y. J., Shim, J. W., & Yoon, J. K. (2020). Canonical WNT/?-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice. Frontiers in Cell and Developmental Biology, 8(May), 1–16. https://doi.org/10.3389/fcell.2020.00264

[34] Kanton, S., Boyle, M. J., He, Z., Santel, M., Weigert, A., Sanchís-Calleja, F., Guijarro, P., Sidow, L., Fleck, J. S., Han, D., Qian, Z., Heide, M., Huttner, W. B., Khaitovich, P., Pääbo, S., Treutlein, B., & Camp, J. G. (2019). Organoid single-cell genomic atlas uncovers human-specific features of brain development. In Nature (Vol. 574, Issue 7778). https://doi.org/10.1038/s41586-019-1654-9

[35] Kashyap, V., Rezende, N. C., Scotland, K. B., Shaffer, S. M., Persson, J. L., Gudas, L. J., and Mongan, N. P. (2009). Regulation of Stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog, OCT4, and SOX2 pluripotency transcription factors with polycomb Repressive Complexes and Stem Cell microRNAs. Stem Cells and Development, 18(7), 1093–1108. https://doi.org/10.1089/scd.2009.0113

[36] Kraushaar, D. C., & Zhao, K. (2013). The epigenomics of embryonic stem cell differentiation. International Journal of Biological Sciences, 9(10), 1134–1144. https://doi.org/10.7150/ijbs.7998

[37] Lara Vellosillo. (2015). Diferenciación de las células estromales de tejido adiposo de rata para la obtención de células con fenotipo Oligodendroglial.

[38] Lee, J., Rabbani, C. C., Gao, H., Steinhart, M. R., Woodruff, B. M., Pflum, Z. E., Kim, A., Heller, S., Liu, Y., Shipchandler, T. Z., & Koehler, K. R. (2020). Hair-bearing human skin generated entirely from pluripotent stem cells. Nature, 582(7812), 399–404. https://doi.org/10.1038/s41586-020-2352-3

[39] Lee, M. B., & Kaeberlein, M. (2018). Translational Geroscience: From invertebrate models to companion animal and human interventions. Translational Medicine of Aging, 2, 15–29. https://doi.org/10.1016/j.tma.2018.08.002

[40] Li, M., & Izpisua Belmonte, J. C. (2018). Deconstructing the pluripotency gene regulatory network. Nature Cell Biology, 20(4), 382–392. https://doi.org/10.1038/s41556-018-0067-6

[41] Liang, R., & Liu, Y. (2018). Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells. Stem Cell Research & Therapy, 9(1), 1–7. https://doi.org/10.1186/s13287-018-1015-x

[42] Liu, L., Michowski, W., Kolodziejczyk, A., & Sicinski, P. (2019). The cell cycle in stem cell proliferation, pluripotency and differentiation. Nature Cell Biology, 21(9), 1060–1067. https://doi.org/10.1038/s41556-019-0384-4

[43] Lodish, Berk, Kaiser, Krieger, Bretscher, & Ploegh. (2018). Molecular Cell Biology. https://doi.org/http://pubs.acs.org/doi/pdf/ 10.1021/ ja309527h.

[44] Long, K. L. P., Breton, J. M., Barraza, M. K., Perloff, O. S., & Kaufer, D. (2021). Hormonal regulation of oligodendrogenesis i: Effects across the lifespan. Biomolecules, 11(2), 1–36. https://doi.org/10.3390/ biom11020283

[45] McPhie, D. L., Nehme, R., Ravichandran, C., Babb, S. M., Ghosh, S. D., Staskus, A., Kalinowski, A., Kaur, R., Douvaras, P., Du, F., Ongur, D., Fossati, V., Eggan, K., & Cohen, B. M. (2018). Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Translational Psychiatry, 8(1). https://doi.org/10.1038/s41398-018-0284-6

[46] Méndez-Maldonado, K., Vega-López, G. A., Aybar, M. J., and Velasco, I. (2020). Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia. Frontiers in Cell and Developmental Biology, 8 (August). https://doi.org/10.3389/fcell.2020.00635

[47] Mercurio, S., Serra, L., & Nicolis, S. K. (2019). More than just stem cells: Functional roles of the transcription factor Sox2 in differentiated glia and neurons. International Journal of Molecular Sciences, 20(18). https://doi.org/10.3390/ijms20184540

[48] Mistri, T. K., Kelly, D., Mak, J., Colby, D., Mullin, N., andChambers, I. (2020). Characterisation of interactions between the pluripotency transcription factors Nanog, Oct4 and Sox2. https://doi.org/10.1101/2020.06.24.169185

[49] Miyamoto, N., & Wada, H. (2013). Hemichordate neurulation and the origin of the neural tube. Nature Communications, 4. https://doi.org/10.1038/ncomms3713

[50] Moreno, C. L., & Mobbs, C. V. (2017). Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet. Molecular and Cellular Endocrinology, 455, 33–40. https://doi.org/10.1016/j.mce.2016.11.013

[51] Moris, N., Pina, C., & Arias, A. M. (2016). Transition states and cell fate decisions in epigenetic landscapes. Nature Reviews Genetics, 17(11), 693–703. https://doi.org/10.1038/nrg.2016.98

[52] Mossahebi-Mohammadi, M., Quan, M., Zhang, J. S., & Li, X. (2020). FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency. Frontiers in Cell and Developmental Biology, 8(February), 1–10. https://doi.org/10.3389/fcell.2020.00079

[53] Murphy, M., Chatterjee, S. S., Jain, S., Katari, M., & Dasgupta, R. (2016). TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. Scientific Reports, 6(June), 1–12. https://doi.org/10.1038/srep28299

[54] Nandi, P., Lim, H., Torres-Garcia, E. J., & Lala, P. K. (2018). Human trophoblast stem cell self-renewal and differentiation: Role of decorin. Scientific Reports, 8(1), 1–14. https://doi.org/10.1038/s41598-018-27119-4

[55] Niwa, H., Nakamura, A., Urata, M., Shirae-Kurabayashi, M., Kuraku, S., Russell, S., & Ohtsuka, S. (2016). The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells. BMC Evolutionary Biology, 16(1), 1–12. https://doi.org/10.1186/s12862-016-0755-4

[56] Noh, H., Shao, Z., Coyle, J. T., & Chung, S. (2017). BBA - Molecular Basis of Disease Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells ( iPSCs ). BBA - Molecular Basis of Disease, 1863(9), 2382–2387. https://doi.org/10.1016/ j.bbadis.2017.06.019

[57] Pan, G. J., Chang, Z. Y. I., Schöler, H. R., & Pei, D. (2002). Stem cell pluripotency and transcription factor Oct4. Cell Research, 12(5–6), 321–329. https://doi.org/10.1038/sj.cr.7290134

[58] Pandima Devi, K., Rajavel, T., Daglia, M., Nabavi, S. F., Bishayee, A., and Nabavi, S. M. (2017). Targeting miRNAs by polyphenols: Novel therapeutic strategy for cancer. Seminars in Cancer Biology, 46, 146–157. https://doi.org/10.1016/j.semcancer.2017.02.001

[59] Perlman, K., Couturier, C. P., Yaqubi, M., Tanti, A., Cui, Q. L., Pernin, F., Stratton, J. A., Ragoussis, J., Healy, L., Petrecca, K., Dudley, R., Srour, M., Hall, J. A., Kennedy, T. E., Mechawar, N., & Antel, J. P. (2020). Developmental trajectory of oligodendrocyte progenitor cells in the human brain revealed by single cell RNA sequencing. GLIA, 68(6), 1291–1303. https://doi.org/10.1002/glia.23777

[60] Pimentel-Parra, G. A., & Murcia-Ordoñez, B. (2017). Células madre, una nueva alternativa médica. Perinatología y Reproducción Humana, 31(1), 28–33. https://doi.org/10.1016/j.rprh.2017.10.013

[61] Ramalho-Santos, M., & Willenbring, H. (2007). On the Origin of the Term “Stem Cell.” Cell Stem Cell, 1(1), 35–38. https://doi.org/10.1016/j.stem.2007.05.013

[62] Rasband, M. N., & Peles, E. (2015). The Nodes of Ranvier?: Molecular Assembly and Maintenance. 1–16.

[63] Rathnam, C., Chueng, S. T. D., Yang, L., & Lee, K. B. (2017). Advanced gene manipulation methods for stem cell theranostics. Theranostics, 7(11), 2775–2793. https://doi.org/10.7150/thno.19443

[64] Rieckher, M., Markaki, M., Princz, A., Schumacher, B., & Tavernarakis, N. (2018). Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans. Cell Reports, 25(1), 199-211.e6. https://doi.org/10.1016/j.celrep.2018.09.009

[65] Rivron, N. C., Frias-Aldeguer, J., Vrij, E. J., Boisset, J. C., Korving, J., Vivié, J., Truckenmüller, R. K., Van Oudenaarden, A., Van Blitterswijk, C. A., & Geijsen, N. (2018). Blastocyst-like structures generated solely from stem cells. Nature, 557(7703), 106–111. https://doi.org/10.1038/s41586-018-0051-0

[66] Savatier, P., & Malashicheva, A. (2004). Cell-Cycle Control in Embryonic Stem Cells. In Handbook of Stem Cells (Vol. 1). Elsevier Inc. https://doi.org/10.1016/B978-012436643-5/50014-6

[67] Sedaghat, F., Cheraghpour, M., Hosseini, S. A., Pourvali, K., Teimoori-Toolabi, L., Mehrtash, A., Talaei, R., & Zand, H. (2019). Hypomethylation of NANOG promoter in colonic mucosal cells of obese patients: A possible role of NF-?B. British Journal of Nutrition, 122(5), 499–508. https://doi.org/10.1017/S000711451800212X

[68] Senft, A. D., Bikoff, E. K., Robertson, E. J., & Costello, I. (2019).

[69] Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse. Nature Communications, 10(1), 1–11. https://doi.org/10.1038/s41467-019-09052-w

[70] Sharma, S., & Bhonde, R. (2020). Genetic and epigenetic stability of stem cells: Epigenetic modifiers modulate the fate of mesenchymal stem cells. Genomics, 112(5), 3615–3623. https://doi.org/10.1016/ j.ygeno.2020.04.022

[71] Shi, J., Shi, W., Ni, L., Xu, X., Su, X., Xia, L., Xu, F., Chen, J., & Zhu, J. (2013). OCT4 is epigenetically regulated by DNA hypomethylation of promoter and exon in primary gliomas. Oncology Reports, 30(1), 201–206. https://doi.org/10.3892/or.2013.2456

[72] Smith, L. R., Cho, S., & Discher, D. E. (2018). Stem cell differentiation is regulated by extracellular matrix mechanics. Physiology, 33(1), 16–25. https://doi.org/10.1152/physiol.00026.2017

[73] Son, J., Tae, J.-Y., Min, S., Ko, Y., & Park, J.-B. (2020). Fibroblast growth factor-4 maintains cellular viability while enhancing osteogenic differentiation of stem cell spheroids in part by regulating RUNX2 and BGLAP expression. Experimental and Therapeutic Medicine, 2013–2020. https://doi.org/10.3892/etm.2020.8951

[74] Song, I., & Dityatev, A. (2018). Crosstalk between glia, extracellular matrix and neurons. Brain Research Bulletin, 136, 101–108. https://doi.org/10.1016/j.brainresbull.2017.03.003

[75] Steinhart, Z., & Angers, S. (2018). Wnt signaling in development and tissue homeostasis. Development (Cambridge, England), 145(11), 1–8. https://doi.org/10.1242/dev.146589

[76] Taupin, P. (2010). Very small embryonic-like stem cells for regenerative medicine: WO2010039241. Expert Opinion on Therapeutic Patents, 20(8), 1103–1106. https://doi.org/10.1517/13543776.2010.495122

[77] Tremble, K., Stirparo, G. G., Bates, L. E., Maskalenka, K., Stuart, H. T., Jones, K., Andersson-Rolf, A., Radzisheuskaya, A., Koo, B. K., Bertone, P., and Silva, J. C. R. (2020). Sox2 modulation increases naïve pluripotency plasticity. In bioRxiv. https://doi.org/10.1101/ 2020.01.14.906933

[78] van Holde, K. E., & Zlatanova, J. (2018). Development and Differentiation. The Evolution of Molecular Biology, 135–147. https://doi.org/10.1016/b978-0-12-812917-3.00013-9

[79] Verneri, P., Vazquez Echegaray, C., Oses, C., Stortz, M., Guberman, A., and Levi, V. (2020). Dynamical reorganization of the pluripotency transcription factors Oct4 and Sox2 during early differentiation of embryonic stem cells. Scientific Reports, 10(1), 1–12. https://doi.org/10.1038/s41598-020-62235-0

[80] Wang, J., Rao, S., Chu, J., Shen, X., Levasseur, D. N., Theunissen, T. W., & Orkin, S. H. (2006). A protein interaction network for pluripotency of embryonic stem cells. Nature, 444(7117), 364–368. https://doi.org/10.1038/nature05284

[81] Weider, M., Starost, L. J., Groll, K., Küspert, M., Sock, E., Wedel, M., Fröb, F., Schmitt, C., Baroti, T., Hartwig, A. C., Hillgärtner, S., Piefke, S., Fadler, T., Ehrlich, M., Ehlert, C., Stehling, M., Albrecht, S., Jabali, A., Schöler, H. R., … Wegner, M. (2018). Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nature Communications, 2018(MARCH), 1–16. https://doi.org/10.1038/s41467-018-03336-3

[82] Xu, L., & Jiang, H. (2020). Writing and Reading Histone H3 Lysine 9 Methylation in Arabidopsis. In Frontiers in Plant Science (Vol. 11). https://doi.org/10.3389/fpls.2020.00452

[83] Xu, Z., Robitaille, A. M., Berndt, J. D., Davidson, K. C., Fischer, K. A., Mathieu, J., Potter, J. C., Ruohola-Baker, H., & Moon, R. T. (2016).

[84] Wnt/?-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 113(42), E6382–E6390. https://doi.org/10.1073/pnas.1613849113

[85] York, J. R., & McCauley, D. W. (2020). The origin and evolution of vertebrate neural crest cells. Open Biology, 10(1). https://doi.org/10.1098/rsob.190285

[86] Yunusova, A. M., Fishman, V. S., Vasiliev, G. V., & Battulin, N. R. (2017). Deterministic versus stochastic model of reprogramming: New evidence from cellular barcoding technique. Open Biology, 7(4). https://doi.org/10.1098/rsob.160311

[87] Zakrzewski, W., Dobrzy?ski, M., Szymonowicz, M., & Rybak, Z. (2019). Stem cells: Past, present, and future. Stem Cell Research and Therapy, 10(1), 1–22. https://doi.org/10.1186/s13287-019-1165-5

[88] Zaveri, L., & Dhawan, J. (2018). Cycling to meet fate: Connecting pluripotency to the cell cycle. Frontiers in Cell and Developmental Biology, 6(JUN), 1–19. https://doi.org/10.3389/fcell.2018.00057

[89] Zhang, H., Shao, X., Peng, Y., Teng, Y., Saravanan, K. M., Zhang, H., Li, H., and Wei, Y. (2019). A novel machine learning based approach for iPS progenitor cell identification. BioRxiv, 744920. https://doi.org/10.1101/744920

Cover image

How to Cite

Download Citation

Abstract

Downloads

References

Keywords

Licencia