MECANISMOS MOLECULARES INVOLUCRADOS EN LA DIFERENCIACIÓN DE CÉLULAS MADRE EN LINAJES GLIALES

José Antonio  Thomas Argüelles; Diego  Reginensi; L. Sebastián A Valerio

doi:10.48204/j.tecno.v25n2.a4070

Submitted July 21, 2023

Published 2023-07-21

Artículos

Vol. 25 No. 2 (2023): Tecnociencia

MOLECULAR MECHANISMS INVOLVED IN THE DIFFERENTIATION OF STEM CELLS INTO GLIAL LINEAGES

José Antonio Thomas Argüelles ⁺⁻
Diego Reginensi ⁺⁻
L. Sebastián A Valerio ⁺⁻

DOI https://doi.org/10.48204/j.tecno.v25n2.a4070

PDF (Español (España))

References

DOI: 10.48204/j.tecno.v25n2.a4070

Published: 2023-07-21

How to Cite

Thomas Argüelles , J. A., Reginensi , D. and A Valerio , L. S. (2023) “MOLECULAR MECHANISMS INVOLVED IN THE DIFFERENTIATION OF STEM CELLS INTO GLIAL LINEAGES”, Tecnociencia, 25(2), pp. 138–168. doi: 10.48204/j.tecno.v25n2.a4070.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

Even though different cell types have different functions and morphologies, they are all descended from a common ancestral cell, also known as stem cells, so they essentially share the same DNA. What differentiates them is molecular dynamics, which involves regulating chemical modifications in the internal microenvironment of cells to modulate the niche of a tissue or organ. One of the main objectives of this review article is to recapitulate the normal development of the organism and how the endogenous regenerative capacity of stem cells can be harnessed. This article defines the key concepts in stem cell biology with respect to the nervous system, presents an overview of oligodendrocyte cell development and its importance in the development of myelination, which requires an experimental model in which neuronal axons and oligodendrocytes can be controlled and manipulated during the process.

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