Protected lands are the most valuable places for in situ conservation of nature. In Panama, these natural spaces are of institutional and management interest due to the environmental benefit they offer, despite intense human pressure to which they are subject. In this sense, National System of Protected Areas (SINAP) of Department of Management of Protected Areas of the Ministry of Environment (MiAmbiente) of Panama, through the Program for Monitoring the Effectiveness of Management of Protected Areas (PMEMAP) verifies all these lands and its current status. Panama has 105 legally established protected areas, of which Colon province have four of them, Portobelo National Park, San Lorenzo Protector Forest and Protected Landscape, Gatun Lake Recreational Area and Galeta Island Protected Landscape. However, since 2012, they have not had an in-depth analysis that describes their particularity around social, environmental, cultural and economic aspects, information that could be useful in the search for possible short, medium and long term lines of action. In this descriptive research on Colon province protected areas and its current situation, based on five axes: social, administrative, economic-financial, political-legal, natural and cultural resources, as well as scientific research and protected land recorded threats,field work was carried out and information from the Department of Protected Area Management of the Ministry of Environment was reviewed. The results show diverse realities in each of the protected areas treated, it is recommended to establish new action plans and strategic alliances supported by environmental education, production and strengthening of scientific knowledge and increase of qualified personnel. On the other hand, recorded threats show a significant increase, which suggests a negative impact on their integrity.