Diabetes mellitus affects more than 346 million people worldwide and the neuropathy is the most common chronic complication of diabetes. 8% of the population in Panama is affected by this disease. The risk factors involved in the development and progression of the disease are associated with poor metabolic control and disease progression. The objective of this study was to determine the correlation between motor nerve conduction velocity and glycosylated hemoglobin in diabetic patients in the Diabetic Clinic of Santo Tomas Hospital. In this descriptive correlational study, a total of thirteen patients with type 2 diabetes mellitus were selected. The electrophysiological evaluation determined variables such as motor nerve conduction velocity (VCNm). Hemoglobin A1c values were measured in all patients. The reference values are based on Santo Tomas Hospital data base. The association between motor nerve conduction velocity and the hemoglobin HbA1c was statistically significant at (P <0.05). Pearson correlation for posterior tibial nerve for r = - 0.61, for medium right and left r = -0.65 and r = - 0.83 and respectively for ulnar r = - 0.66 and r = - 0.73 right and left. An inverse correlation between the association of motor nerve conduction velocity and glycated hemoglobin was observed in 83.3% of sample studied.