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Computer ergonomics is an essential component in assessing workstations with visual display terminals (VDTs), as it safeguards occupational health and enhances organizational efficiency. This study aimed to analyze the influence of applying ergonomic engineering criteria on the audit of computer and process management systems in companies in the Republic of Panama during the period 2024–2025. The research adopted a correlational, explanatory, and qualitative approach, combining direct observation, structured surveys, semi-structured interviews, and checklists based on ISO 9241, ISO 19011:2018, and UNE-EN standards. Results indicate that more than 50% of the audited workstations present significant ergonomic deficiencies, including inadequate furniture, poor spatial layout, insufficient lighting, and disorganized cabling. These conditions negatively impact productivity, occupational well-being, and the quality of internal IT processes. Recurrent symptoms such as carpal tunnel syndrome, visual fatigue, lower back pain, and cervical tension were identified. Moreover, levels of effectiveness, efficiency, and efficacy (EEE) showed a positive correlation with compliance with ergonomic and engineering criteria. The study concludes that the systematic application of computer ergonomics standards and auditing principles strengthens organizational management, enhances worker comfort and health, and promotes safer, more efficient, and sustainable technological environments.