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Panama faces major challenges associated with the incorporation of sustainability precepts, of which sustainable construction is essential to boost economic growth and also to carry out climate change adaptation strategies. An adequate design of the enclosures (envelope) of a building will allow maximum use of diffused natural lighting and will serve as protection against direct solar radiation. Sunscreens, in the case of bankrupt soles, reduce the internal overheating of the environments and can also facilitate the entry of diffused natural light and redirect the sun's rays inwards. The present study evaluates the performance of natural lighting based on variables, such as the envelope (bankrupt suns), in building 205 of the City of Knowledge, where the Senacyt offices are located. In addition, it is studied whether the vegetation located in front of one of its facades interferes with the levels of internal lighting. Measurements were made with luxometers and the lighting levels were verified based on the European standard EN12464-1, which specifies that offices must have minimum values ??of 500 lux. The results indicated that two of the four rooms evaluated meet the minimum levels required by the standard. Room 101 has a maximum of 505 lux; the general service room: 375 lux; room 206: 596 lux and room 329: 444 lux.