The present study is developed in the metropolitan area of Panama City in San Francisco, specifically in the surroundings of Calle 50. This area of study is attractive because it is central and, therefore, very busy, it presents a mixed urban model, with high and low buildings, with different width of streets, green areas, and crossed by the Matasnillo River. This study's main objective is to evaluate the relationship between urban microclimate variables concerning urban morphology parameters. Based on the results, we can indicate that the parameters of an urban morphology that significantly impact the thermal sensation in this area are the H/W and the SVF. However, the thermal sensation remains homogeneous throughout the area, indicating the existence of a direct linear relationship between the micro-climatic variables, temperature, and the morphological H/W and SVF in the surroundings of the Calle 50 area.