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This article studies three key aspects for understanding the history of colonial Panama. Objective: to analyze the founding of the city of Panama as part of the first great geopolitical vision of the Catholic Monarchs for the New World; to examine the Town Council (Cabildo) as the body of legal representation of the city and an instrument of power and economic control of the local elites; and to assess the role of Panama in the origins of globalization, the wealth of its residents and the moments of prosperity and paralysis of the local economy. Method: a historical analysis based on primary sources from the Archivo General de Indias and on a critical review of Spanish American historiography on colonial institutions. Results: the founding of Panama in 1519 is shown to have been part of a single imperial project linked to the discovery of the Pacific and to Magellan's voyage; the Town Council, despite Crown intervention and the sale of offices that turned it into a plutocratic body, retained effective power against the Real Audiencia until it led the independence movement of 1821; and the trans-isthmian function inserted Panama into the first world economy. Conclusion: the interaction between city, town council and global trade explains the wealth, power and trajectory of colonial Panama over three centuries, until independence from Spain.