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The purpose of this investigation is to unravel the formulation of
the components of the university mission during the gestation of the University of Panama, within the framework of the oscillation between a Pan-American and a national project. The achievement of the expected results found support in the historical logical method, which, in addition to describing the course of events and the impact of historical conditions, uncovers the trajectory of the founding mission statement. It is based on documentary analysis, especially of relevant discourses and content. Eleven years into the university’s existence, the dilemma between a Pan- American or Panamanian university project has been resolved with the definitive adoption of the national alternative under the name of the University of Panama. The Political Constitution of 1946 grants it autonomy and mandates that its activities must include the study of national problems and cultural dissemination. Law 48 of 1946 established the name of the University of Panama and established its substantive functions: the study of professions, scientific research, cultural dissemination, and the provision of curricula in line with social aspirations and demands. This institutionalization demonstrates an initial comprehensive process of the university’s original mission.