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This article provides a descriptive, analytical approach to certain historical events of the Panamanian nation in the first half of the 20th century, using other historical-philosophical perspectives. This approach allows us to consider the “Why?” of US political actions and their impact on our territory. From this historical-philosophical perspective, the nationalist struggles of the Panamanian people against the US colonial enclave in the Canal Zone and the radical, pragmatic Monroeist policy of the United States will be analyzed. As a result, during the Roberto Chiari administration, Panamanians demanded the elimination of the US presence and the revision of the treaties that granted the US privileges over the Canal. The conflict reached its peak on January 9, 1964. The confrontation between Panamanian nationalism and the pragmatic Monroeist policy of the United States during this first period of the 20th century highlighted Panama’s struggle for self-determination and Washington’s resistance to ceding the strategic power afforded it by the Canal Zone, marking a turning point in Panamanian history and on the path to the full recovery of the Canal in 1999. In 2001, after the Monroe Doctrine and almost a century and a half after the emergence of the pragmatic current in the United States, these two principles still influence American policy.