Institutions in Panama have had to face radical transformations at the level of digitization processes. Electronic invoicing empowers companies to automate the processing of their invoices, so the entire business ecosystem favors their implementation. Through implementations of the SAP R/3 electronic invoicing computer systems, digital certificates, EDI, and IDOC. The main objective of electronic invoicing is based on streamlining the purchase of goods and services, improving the administration and audit processes that government institutions operate on companies. The main idea is that this research serves as a reference for implementations in SAP R/3 applications in different companies, especially in multinational organizations where due to security and compliance issues, access to the SAP R/3 application is more directly restricted, so the only way to connect SAP R/3 with third-party applications is through interfaces where flat files or IDOC’s are exchanged.