The study explored the correlation between coping styles and resilience in patients undergoing chemotherapy treatment for cancer. For data collection, the Coping with Stress Questionnaire for Oncological Patients (CAEPO) and Wagnild and Young's Resilience Scale were utilized. A correlational design was employed with a sample of 120 patients, analyzing the data through Spearman's correlation coefficient. The results revealed a significant and positive correlation between both variables (? = .675, p < ,05), indicating that coping strategies strengthen resilience and promote emotional well-being during oncological treatment. The discussion highlighted the importance of adaptive mechanisms such as active coping, positive reinterpretation, and social support. Finally, the study underscores the need to incorporate specialized psychological interventions through a six-phase proposal oriented toward the assessment, development, and integration of coping skills in oncological care.