This article examines the relationship between investments in securities and the loan portfolio of Banco Multibank in Panama for the period January 2024 to April 2025. Using a quantitative approach, growth rate (TC?%) and percentage participation (PP?%) indicators were applied, along with a simple linear regression econometric model. The data were drawn from monthly reports published by the bank and Panama’s Superintendency of Banks. Results reveal a positive and significant relationship between both variables. The model yielded a determination coefficient of R² = 0.8858, indicating that 88.58% of the loan portfolio's variability is explained by investment performance. These findings reflect a coherent financial strategy and efficient resource management that supports credit expansion. The research offers relevant insights for institutional analysis and decision-making in the banking sector.