This article analyzes the relationship between the main financial indicators of Banco General of Panama and the Monthly Index of Economic Activity (IMAE) during the period 2024:01–2025:07, applying an econometric approach. The study integrates theoretical concepts of financial function and Ordinary Least Squares (OLS) models. Using monthly data from Banco General, the Superintendency of Banks of Panama, and the Comptroller General of the Republic, a database was constructed to calculate indicators such as growth rate (TC%) and percentage participation (PP%), describing the structural behavior of credit portfolio, deposits, investments, equity, obligations, and liquid assets. The results revealed a stable trend, with controlled growth of the credit portfolio and a prudent liquidity policy. The econometric models showed coefficients of determination (R²) ranging between 0.19 and 0.21. The credit portfolio, investments in securities, and liquid assets exhibited positive effects on the IMAE, while equity and obligations reflected inverse relationships. The statistical significance of the liquid assets indicator (p = 0.0078) confirmed the importance of liquidity in driving economic growth. Banco General maintains a countercyclical and stabilizing behavior, adjusting its financial strategy according to macroeconomic conditions. The empirical evidence demonstrates coherence between its financial functions and the stability of the Panamanian banking system, consolidating the institution as a key agent in efficient intermediation and the sustainable economic development of the country.