Business cycles are fluctuations in the aggregate economic activity of countries and represent a reflection of the performance of companies and Government, employment, income, consumption and other macroeconomic indicators. The province of Colon has experienced fluctuations in its economic performance highlighting a strong instability in the different sectors and activities. The purpose of this study is to examine the business cycles in the province of Colon under a government administrations perspective between the periods 1999 to 2019. The research is exploratory and descriptive, and the literature review has not identified previous references on this topic. The results show a continuous volatility in the growth of the province, showing the limited sustainability of its economic activities throughout the different governments. The Varela administration registered the most notable growth rates during its period (25.0% in 2015, 28.2% in 2016, 23.0% in 2017 and 8.1% in 2018); however, an in-depth analysis of the data demonstrated that construction-related activities due to the so-called “Renovation Effect” generated a stochastic growth in provincial indicators with little sustainability in Colon's economic performance. The study concludes that Government investments and public policies enhancing the local economy should be oriented to reinforce traditional activities from a region. In the case of Colon, the evidence suggests strengthening economic activities related to trade and services, since these are historically natural, proper and sustainable in the province.