Copyright (c) 2026 Revista médico científica
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Persistent pulmonary hypertension of the newborn represents a serious disorder at birth in which there is no adequate transition from the fetal to the neonatal circulatory system. It is associated with various conditions that directly or indirectly affect the pulmonary vasculature. Clinical signs mainly include respiratory distress such as nasal flaring, tachypnea, intercostal retractions, and cyanosis. Diagnosis relies on clinical history, physical examination, pre- and post-ductal oxygen saturation, arterial blood gas analysis, chest X-ray, and echocardiography. Differential diagnoses include cyanotic congenital heart diseases and parenchymal lung diseases without pulmonary hypertension. Treatment focuses on optimizing oxygenation and reducing pulmonary vascular resistance using vasodilators, oxygen therapy, and other supportive measures. Prognosis depends on the underlying cause and the effectiveness of therapeutic interventions.
