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An intracerebral hemorrhage (IH) is characterized by bleeding in the parenquimatous region, which may expand to other areas of the brain. As the third leading cause of stroke , patients suffering from IH have the highest mortality rates, as the condition is untreatable. Considerable debate as to the etiology of primary or spontaneous IH persists. Additionally, the role of platelet polymorphism, or surface glycoproteins, which enable platelet aggregation during IH is unknown .
A 75 year-old male complains of acute onset neurological symptoms characteristic of local seizures in the upper right segment such as dizziness, severe headaches , and progressive weakness on the right side of his body (hemiplegia). The palient has a long history of hypertension.
Laboratory data show coagulation tests that lall within normal limits and normal platelet count and platelet size. However, defects were observed in the platelet functionality with abnormalities in the aggregation with ATP and adrenaline . In addition we found insufficient activity of the CD41/CD61 receptor corresponding to with the GP IIb-IIIa receptor and the CD62P receptor of P-selectine.
In a rare mixture between neurosurgery and medical (hematological) science, it has been shown that spontaneous intracerebral hemorrhage can be attributed to a syndrome like Trombastenia of Glanzman .
