Amniotic fluid was collected from 31 high risk pregnancy women in order to conduct prenatal diagnosis of chromosomal aberrations by chromosome G banding technique. Maternal age and low levels of alpha fetoprotein in maternal serum was used as a high risk factors. The diagnosis was achieved in twenty three of the thirty one samples. Fourteen was normal girl with karyotype 46 XX, six was normal kids with karyotype 46, XY and three with chromosoamal aberrations. The chromosomal aberrations observed was 21 trisomy with karyotype 47, XY+21, non reciprocal translocation between chromosome 8 and 18 with deletion in the short arm of chromosome 9 with karyotype 45, XY, t(8:18) (p ter : p ter), del 9p ter and a pericentric inversion of chromosome 9 46, XY inv(9). The percentage of chromosomal aberrations observed in samples from mother with advanced maternal age was 12.5 % (2/16).