Determinación del polimorfismo pro12ala en el receptor activado por proliferadores de peroxisomas gamma-2 en pacientes que padecen diabetes mellitus tipo 2

Evelyn Visuete; Tomás A. Diez; Edgardo Castro; Magaly de Chial; Ana E. Tejada; Carlos W. Ramos D.

doi:10.48204/j.tecno.v27n1.a6641

Submitted December 27, 2024

Published 2025-01-03

Artículos

Vol. 27 No. 1 (2025): Tecnociencia

Determination of the pro12ala polymorphism in peroxisome proliferator-activated receptor gamma-2 in patients with type 2 diabetes mellitus.

Evelyn Visuete ⁺⁻
Tomás A. Diez ⁺⁻
Edgardo Castro⁺⁻
Magaly de Chial⁺⁻
Ana E. Tejada ⁺⁻
Carlos W. Ramos D.⁺⁻

DOI https://doi.org/10.48204/j.tecno.v27n1.a6641

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References

DOI: 10.48204/j.tecno.v27n1.a6641

Published: 2025-01-03

How to Cite

Visuete , E., Diez , T. A., Castro, E., de Chial, M., Tejada , A. E. and Ramos D., C. W. (2025) “Determination of the pro12ala polymorphism in peroxisome proliferator-activated receptor gamma-2 in patients with type 2 diabetes mellitus”., Tecnociencia, 27(1), pp. 125–144. doi: 10.48204/j.tecno.v27n1.a6641.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

Diabetes mellitus is a group of common metabolic disorders that share the phenotype of hyperglycemia. The Pro12Ala polymorphism in exon B of the gene that codes for PPARg2 has been associated, in some populations, with type 2 diabetes. The objective of this study was to determine if there is an association between the Pro12Ala polymorphism of PPARgn2 and type 2 diabetes mellitus in a sample of the Panamanian population. The possible association of the Pro12Ala polymorphism was evaluated in a sample of 195 individuals (99 controls and 96 experimental). The Pro12Ala polymorphism was detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. A higher frequency of the Pro12Ala genotype was observed in the experimental group (DM2) compared to the control group (0.114 vs 0.010). The frequency of the Ala12 allele (lowest frequency allele) in our study was 2.8%. This work represents the first study on the association between type 2 diabetes mellitus and the Pro12Ala polymorphism (rs18012829) in a sample of cases and controls in Panama. The odds ratio (OR) showed an association with a relative risk of 1.9735 in those with the Pro12Ala genotype. The frequency of the Pro12Ala genotype was higher in women, suggesting that they may be more predisposed to developing this condition.

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References

Ahmed, S. A. H., Ansari, S. A., Mensah-Brown, E. P. K. & Emerald, B. S. (2020). Clinical Epigenetics. 12:104 https://doi.org/10.1186/s13148-020-00896-4
Altshuler, D., Hirschhorn, J., Klannemark, M. et al. (2000). The common PPAR? Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26, 76–80. https://doi.org/10.1038/79216
Andrulionyté, L., Zacharova, J., Chiasson, J. et al. (2004). Common polymorphisms of the PPAR-?2 (Pro12Ala) and PGC-1? (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. Diabetologia, 47(12), 2176–2184. https://doi.org/10.1007/s00125-004-1577-2
AsocMexDiabetes. (2021, 30 junio). TRANSPORTADORES DE GLUCOSA (GLUTS). Asociación Mexicana. https://www.amdiabetes.org/post/transportadores-de-glucosa-gluts
Badii, R., Bener, A., Zirie, M. et al. (2008). Lack of association between the Pro12ALA polymorphism of the PPAR-?2 gene and Type 2 diabetes mellitus in the Qatari consanguineous population. Acta Diabetologica, 45(1), 15-21. https://doi.org/10.1007/s00592-007-0013-8
Bouassida, K., Chouchane, L., Jellouli, K. et al. (2005). The peroxisome proliferator activated receptorgamma2 (PPARgamma2) Pro12Ala variant: lack of association with type 2 diabetes in obese and non obese Tunisian patients. Diabetes Metab; 31(2):119-23. doi: 10.1016/s1262-3636(07)70177-5.
Cañizales-Quinteros, Aguilar-Salinas, C., Ortiz-López, M G. et al. (2007). Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico. Hum Biol. 79(1):111-9. doi: 10.1353/hub.2007.0022.
Castro, E., Trejos, D., Hrbek, T. et al. (2016). Genetic Ancestry of the Panamanian Population: Polymorphic Structure, Chibchan Amerindian Genes; and Biological Perspectives on Diseases. The Internet Journal of Biological Anthropology. Volume 9 Number 1. Doi: 10.5580/IJBA.44045
Chistiakov, D. A., Potapov, V. A., Nosikov, V. V. et al. (2010) The PPARgamma Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects. Diab. Vasc. Dis. Res. 7, 56–62. https://doi.org/10.1177/1479164109347689
Christiansen, C., Arathimos, R., Pain, O. et al. (2023). Stratified genome-wide association análisis of type2 diabetes reveals subgroups with genetic and environmental heterogeneity. Human Molecular Genetics 32 (16): 2638-2645.
Cohen, A. M., Bavly, S. & Poznanski, R. (1961). Change of diet of Yemenite Jews in relation to diabetes and ischemic heart disease. Lancet 21399-1401.
Danawati, C. W., Nagata, M., Moriyama, H. et al. (2005). A possible association of Pro12ALA polymorphism in peroxisome proliferator-activated receptor ?2 gene with obesity in native Javanese in Indonesia. Diabetes/Metabolism Research and Reviews, 21(5), 465-469. https://doi.org/10.1002/dmrr.543
Doney, A., Fischer, B., Cecil, J. et al. (2004). Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes. Diabetologia 47, 555–558.
EpI InfoTM | CDC. (s. f.). https://www.cdc.gov/epiinfo/index.html
Evans, D. et al. (2001). Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes. Exp. Clin. Endocrinol. Diabetes109, 151–154, 10.1055/s-2001-14838.
Florez, J. et al.( 2007). Diabetes Prevention Program Research Group. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. J Clin Endocrinol Metab. 2007 Apr;92(4):1502-9. doi: 10.1210/jc.2006-2275.
Fornage, M. et al. (2005). Inverse effects of the PPARc2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites The CARDIA study. Metabolism Clinical and Experimental, 54, 910 – 917
Frederiksen, L. et al. (2002). Comentario: estudios del polimorfismo Pro12Ala del gen PPAR-gamma en la cohorte danesa MONICA: la homocigosidad del alelo Ala confiere un menor riesgo de síndrome de resistencia a la insulina. J Clin Endocrinol Metab. 87: 3989–3992.
Gardner, L. I. et al. (1984). Prevalence of diabetes in Mexican Americans: relationship to percent of gene pool derived from Native American genetic admixture. Diabetes 3336-92.
Ghoussaini, M. et al. (2005). Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population. BMC Med Genet. 22;6:11.doi:10.1186/1471-2350-6-11.
Gouda, H. et al. (2010). The Association Between the Peroxisome Proliferator-Activated Receptor-g2 (PPARG2) Pro12Ala Gene Variant and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis. Am. J. Epidemiol 171:645-655. doi: 10.1093/aje/kwp450
Hara, K. et al. (2000). The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun. 29;271(1):212-6 doi: 10.1006/bbrc.2000.2605.
Hamman, R. (1992). Genetics and environmental determinants of Non-Insulin Dependent Diabetes Mellitus (NIDDM). DiabetesIMetabolism Reviews, Vol. 8, No. 4, 287-338
Hegele, R. A. et al. (2000). Peroxisome Proliferator-Activated Receptor-?2 P12A and Type 2 diabetes in Canadian Oji-Cree. The Journal of Clinical Endocrinology & Metabolism, 85(5), 2014-2019. https://doi.org/10.1210/jcem.85.5.6610
Hur, H. et al. (2022). Association of Polygenic Variants with Type 2 Diabetes Risk and Their Interaction with Lifestyles in Asians. Nutrients, 14, 3222. https:// doi.org/10.3390/ nu141 53222
Irgam, K. et al. (2021). The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad. BMC Medical Genomics. 14:272
Iyengar, S. et al. (1991). Amerindian admixture among the Anglo and Hispanic ethnic groups in the San Luis Valley, Colorado. Am f Phys Anthropol Suppl. 12:97-98.
Janani, C., & Ranjitha Kumari, B. (2014). PPAR gamma gene – A review. Diab Met Syndr: Clin Res Rev, http://dx.doi.org/10.1016/j.dsx.2014.09.015
Jaziri, R. et al. (2006). The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Diabetes 55 1157–1162
Kawate, R. et al. (1979) Diabetes mellitus and its vascular complications in Japanese migrants and on the island of Hawaii. Diabetes Cure 2:161-170.
Kilpelainen, T. et al. (2008). SNPs in PPARG associate with type 2 diabetes and interact with physical activity. Med Sci Sports Exerc. 40(1):25-33. doi: 10.1249/mss.0b013e318159d1cd.
Kirk, B. et al. (2002). Single Nucleotide Polymorphism seeking long term association with complex disease. Nucleic Acid Research. Vol 30 No 15 3295-3311
Klimentidis, Y., Miller, G., & Shriver, M. (2009). The Relationship Between European Genetic Admixture and Body Composition Among Hispanics and Native Americans. Am. J. Hum. Biol. 21:377–382.
Ling, C., Bacos, K. & Rönn, T. (2022). Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine?. Nat Rev Endocrinol 18, 433–448. https://doi.org/10.1038/s41574-022-00671-w
Lucier, J., Weinstock RS. Type 1 Diabetes. (2023) Mar 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29939535.
Majid, M. et al. (2017) Association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) gene with type 2 diabetes mellitus in ethnic Kashmiri population. Biochem Genet. 55, 10–21, https://doi.org/10.1007/s10528-016-9765-6
Malecki, M. et al. (2003). The Pro12Ala polymorphism of PPARgamma2 gene and susceptibility to type 2 diabetes mellitus in a Polish population. Diabetes Res Clin Pract 62(2):105-11. doi: 10.1016/s0168-8227(03)00164-5.
Mancini, F. et al. (1999). Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes. Diabetes;48(7):1466-8. doi: 10.2337/diabetes.48.7.1466.
Memisoglu, A. et al. (2003). Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Hum Mol Genet. 12(22):2923-9. doi: 10.1093/hmg/ddg318. Epub 2003 Sep 23. PMID: 14506127.
Meshkani, R. et al. (2007). Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population. Clin Chem Lab Med. 45(4):477-82. doi: 10.1515/CCLM.2007.095.
Moffett, S. et al. (2005). The C161 —>?T polymorphism in peroxisome proliferator-activated receptor gamma, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: evidence for another functional variant in peroxisome proliferator-activated receptor gamma. Metabolism 54:1552–1556
Moon, M. et al. (2005). Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population. Diabet. Med.22, 1161–1166, doi:10.1111/j.1464-5491.2005.01599.x
Namvaran, F., Rahimi-Moghaddam, P. & Azarpira, N. (2010). Genotyping of peroxisome proliferator-activated receptor gamma (PPAR-?) polymorphism (Pro12Ala) in Iranian population. JRMS; 16(3): 291-296
Organización Mundial de la Salud, Informe Mundial sobre la Diabetes, noviembre de 2021.
Pintérová, D. et al. (2004). The frequency of alleles of the Pro12Ala polymorphism in PPAR?2 is different between healthy controls and patients with type 2 diabetes. Folia Biologica (Praha), 50: 153-156.
Poulsen, P. et al. (2003). Impact of two common polymorphisms in the PPAR? gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both? Diabetes. 52(1):194–198.
Priya S.S. et al. (2016). Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus- A Pilot Study. Journal of Clinical and Diagnostic Research. Vol-10(2): FC11-FC14
Sarhangi, N. et al. (2020). PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis. Sci Rep 10, 12764. https://doi.org/10.1038/s41598-020-69363-7
Soriguer, F. et al. (2006). Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid. J Nutr. 136(9):2325-30. doi: 10.1093/jn/136.9.2325.
Stryjecki, C. et al. (2015). Association between PPAR-?2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children. Scientific Reports | 6:24472 DOI: 10.1038/srep24472
Stumvoll, M. & Haring, H., (2002). The peroxisome proliferator-activated receptorgamma2 Pro12Ala polymorphism. Diabetes. 51(8):2341-7. doi: 10.2337/diabetes.51.8.2341.
Torun, B. et al. (2002). Rural-tourban migration and cardiovascular disease risk factors in young Guatemalan adults. International Journal of Epidemiology. 31: 218-226
Vales-Villamarín, C. et al. (2021). PPARc2 Pro12Ala Polymorphism is Associated in Children With Traits Related to Susceptibility to Type 2 Diabetes. Front. Pharmacol. 12:763853. doi: 10.3389/fphar.2021.763853
Vergotine, Z. et al. (2014). Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa. BMC Genet. 15, 10, https://doi.org/10.1186/1471-2156-15-10
Weiss, K., Ferrell, R., & Hanis, C. (1984). A New World syndrome of metabolic disease with a genetic and evolutionary basis. Yearbook Phys Anthropol 27:153-178.
West, K. (1978). Epidemiology of Diabetes and its Vascular Lesions. Elsevier Biomedical Press, New York.
Westman E. (2021). Type 2 Diabetes Mellitus: A Pathophysiologic Perspective. Front Nutr. 10;8:707371. doi: 10.3389/fnut.707371.
Zárate, A., Saucedo, R., & Hernández, M. (2005) El receptor de peroxisoma-proliferador-activado gamma (PPAR?) es un factor de transcripción multigénico de versatilidad metabólica. Acta Med. 3(1):53-54.
Zeggini, E. et al. (2005). Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples. Diabet Med. 22(12):1696-700. doi: 10.1111/j.1464-5491.2005.01717. x.

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[1] Ahmed, S. A. H., Ansari, S. A., Mensah-Brown, E. P. K. & Emerald, B. S. (2020). Clinical Epigenetics. 12:104 https://doi.org/10.1186/s13148-020-00896-4

[2] Altshuler, D., Hirschhorn, J., Klannemark, M. et al. (2000). The common PPAR? Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26, 76–80. https://doi.org/10.1038/79216

[3] Andrulionyté, L., Zacharova, J., Chiasson, J. et al. (2004). Common polymorphisms of the PPAR-?2 (Pro12Ala) and PGC-1? (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. Diabetologia, 47(12), 2176–2184. https://doi.org/10.1007/s00125-004-1577-2

[4] AsocMexDiabetes. (2021, 30 junio). TRANSPORTADORES DE GLUCOSA (GLUTS). Asociación Mexicana. https://www.amdiabetes.org/post/transportadores-de-glucosa-gluts

[5] Badii, R., Bener, A., Zirie, M. et al. (2008). Lack of association between the Pro12ALA polymorphism of the PPAR-?2 gene and Type 2 diabetes mellitus in the Qatari consanguineous population. Acta Diabetologica, 45(1), 15-21. https://doi.org/10.1007/s00592-007-0013-8

[6] Bouassida, K., Chouchane, L., Jellouli, K. et al. (2005). The peroxisome proliferator activated receptorgamma2 (PPARgamma2) Pro12Ala variant: lack of association with type 2 diabetes in obese and non obese Tunisian patients. Diabetes Metab; 31(2):119-23. doi: 10.1016/s1262-3636(07)70177-5.

[7] Cañizales-Quinteros, Aguilar-Salinas, C., Ortiz-López, M G. et al. (2007). Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico. Hum Biol. 79(1):111-9. doi: 10.1353/hub.2007.0022.

[8] Castro, E., Trejos, D., Hrbek, T. et al. (2016). Genetic Ancestry of the Panamanian Population: Polymorphic Structure, Chibchan Amerindian Genes; and Biological Perspectives on Diseases. The Internet Journal of Biological Anthropology. Volume 9 Number 1. Doi: 10.5580/IJBA.44045

[9] Chistiakov, D. A., Potapov, V. A., Nosikov, V. V. et al. (2010) The PPARgamma Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects. Diab. Vasc. Dis. Res. 7, 56–62. https://doi.org/10.1177/1479164109347689

[10] Christiansen, C., Arathimos, R., Pain, O. et al. (2023). Stratified genome-wide association análisis of type2 diabetes reveals subgroups with genetic and environmental heterogeneity. Human Molecular Genetics 32 (16): 2638-2645.

[11] Cohen, A. M., Bavly, S. & Poznanski, R. (1961). Change of diet of Yemenite Jews in relation to diabetes and ischemic heart disease. Lancet 21399-1401.

[12] Danawati, C. W., Nagata, M., Moriyama, H. et al. (2005). A possible association of Pro12ALA polymorphism in peroxisome proliferator-activated receptor ?2 gene with obesity in native Javanese in Indonesia. Diabetes/Metabolism Research and Reviews, 21(5), 465-469. https://doi.org/10.1002/dmrr.543

[13] Doney, A., Fischer, B., Cecil, J. et al. (2004). Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes. Diabetologia 47, 555–558.

[14] EpI InfoTM | CDC. (s. f.). https://www.cdc.gov/epiinfo/index.html

[15] Evans, D. et al. (2001). Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes. Exp. Clin. Endocrinol. Diabetes109, 151–154, 10.1055/s-2001-14838.

[16] Florez, J. et al.( 2007). Diabetes Prevention Program Research Group. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. J Clin Endocrinol Metab. 2007 Apr;92(4):1502-9. doi: 10.1210/jc.2006-2275.

[17] Fornage, M. et al. (2005). Inverse effects of the PPARc2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites The CARDIA study. Metabolism Clinical and Experimental, 54, 910 – 917

[18] Frederiksen, L. et al. (2002). Comentario: estudios del polimorfismo Pro12Ala del gen PPAR-gamma en la cohorte danesa MONICA: la homocigosidad del alelo Ala confiere un menor riesgo de síndrome de resistencia a la insulina. J Clin Endocrinol Metab. 87: 3989–3992.

[19] Gardner, L. I. et al. (1984). Prevalence of diabetes in Mexican Americans: relationship to percent of gene pool derived from Native American genetic admixture. Diabetes 3336-92.

[20] Ghoussaini, M. et al. (2005). Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population. BMC Med Genet. 22;6:11.doi:10.1186/1471-2350-6-11.

[21] Gouda, H. et al. (2010). The Association Between the Peroxisome Proliferator-Activated Receptor-g2 (PPARG2) Pro12Ala Gene Variant and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis. Am. J. Epidemiol 171:645-655. doi: 10.1093/aje/kwp450

[22] Hara, K. et al. (2000). The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun. 29;271(1):212-6 doi: 10.1006/bbrc.2000.2605.

[23] Hamman, R. (1992). Genetics and environmental determinants of Non-Insulin Dependent Diabetes Mellitus (NIDDM). DiabetesIMetabolism Reviews, Vol. 8, No. 4, 287-338

[24] Hegele, R. A. et al. (2000). Peroxisome Proliferator-Activated Receptor-?2 P12A and Type 2 diabetes in Canadian Oji-Cree. The Journal of Clinical Endocrinology & Metabolism, 85(5), 2014-2019. https://doi.org/10.1210/jcem.85.5.6610

[25] Hur, H. et al. (2022). Association of Polygenic Variants with Type 2 Diabetes Risk and Their Interaction with Lifestyles in Asians. Nutrients, 14, 3222. https:// doi.org/10.3390/ nu141 53222

[26] Irgam, K. et al. (2021). The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad. BMC Medical Genomics. 14:272

[27] Iyengar, S. et al. (1991). Amerindian admixture among the Anglo and Hispanic ethnic groups in the San Luis Valley, Colorado. Am f Phys Anthropol Suppl. 12:97-98.

[28] Janani, C., & Ranjitha Kumari, B. (2014). PPAR gamma gene – A review. Diab Met Syndr: Clin Res Rev, http://dx.doi.org/10.1016/j.dsx.2014.09.015

[29] Jaziri, R. et al. (2006). The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Diabetes 55 1157–1162

[30] Kawate, R. et al. (1979) Diabetes mellitus and its vascular complications in Japanese migrants and on the island of Hawaii. Diabetes Cure 2:161-170.

[31] Kilpelainen, T. et al. (2008). SNPs in PPARG associate with type 2 diabetes and interact with physical activity. Med Sci Sports Exerc. 40(1):25-33. doi: 10.1249/mss.0b013e318159d1cd.

[32] Kirk, B. et al. (2002). Single Nucleotide Polymorphism seeking long term association with complex disease. Nucleic Acid Research. Vol 30 No 15 3295-3311

[33] Klimentidis, Y., Miller, G., & Shriver, M. (2009). The Relationship Between European Genetic Admixture and Body Composition Among Hispanics and Native Americans. Am. J. Hum. Biol. 21:377–382.

[34] Ling, C., Bacos, K. & Rönn, T. (2022). Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine?. Nat Rev Endocrinol 18, 433–448. https://doi.org/10.1038/s41574-022-00671-w

[35] Lucier, J., Weinstock RS. Type 1 Diabetes. (2023) Mar 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29939535.

[36] Majid, M. et al. (2017) Association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) gene with type 2 diabetes mellitus in ethnic Kashmiri population. Biochem Genet. 55, 10–21, https://doi.org/10.1007/s10528-016-9765-6

[37] Malecki, M. et al. (2003). The Pro12Ala polymorphism of PPARgamma2 gene and susceptibility to type 2 diabetes mellitus in a Polish population. Diabetes Res Clin Pract 62(2):105-11. doi: 10.1016/s0168-8227(03)00164-5.

[38] Mancini, F. et al. (1999). Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes. Diabetes;48(7):1466-8. doi: 10.2337/diabetes.48.7.1466.

[39] Memisoglu, A. et al. (2003). Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Hum Mol Genet. 12(22):2923-9. doi: 10.1093/hmg/ddg318. Epub 2003 Sep 23. PMID: 14506127.

[40] Meshkani, R. et al. (2007). Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population. Clin Chem Lab Med. 45(4):477-82. doi: 10.1515/CCLM.2007.095.

[41] Moffett, S. et al. (2005). The C161 —>?T polymorphism in peroxisome proliferator-activated receptor gamma, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: evidence for another functional variant in peroxisome proliferator-activated receptor gamma. Metabolism 54:1552–1556

[42] Moon, M. et al. (2005). Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population. Diabet. Med.22, 1161–1166, doi:10.1111/j.1464-5491.2005.01599.x

[43] Namvaran, F., Rahimi-Moghaddam, P. & Azarpira, N. (2010). Genotyping of peroxisome proliferator-activated receptor gamma (PPAR-?) polymorphism (Pro12Ala) in Iranian population. JRMS; 16(3): 291-296

[44] Organización Mundial de la Salud, Informe Mundial sobre la Diabetes, noviembre de 2021.

[45] Pintérová, D. et al. (2004). The frequency of alleles of the Pro12Ala polymorphism in PPAR?2 is different between healthy controls and patients with type 2 diabetes. Folia Biologica (Praha), 50: 153-156.

[46] Poulsen, P. et al. (2003). Impact of two common polymorphisms in the PPAR? gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both? Diabetes. 52(1):194–198.

[47] Priya S.S. et al. (2016). Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus- A Pilot Study. Journal of Clinical and Diagnostic Research. Vol-10(2): FC11-FC14

[48] Sarhangi, N. et al. (2020). PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis. Sci Rep 10, 12764. https://doi.org/10.1038/s41598-020-69363-7

[49] Soriguer, F. et al. (2006). Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid. J Nutr. 136(9):2325-30. doi: 10.1093/jn/136.9.2325.

[50] Stryjecki, C. et al. (2015). Association between PPAR-?2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children. Scientific Reports | 6:24472 DOI: 10.1038/srep24472

[51] Stumvoll, M. & Haring, H., (2002). The peroxisome proliferator-activated receptorgamma2 Pro12Ala polymorphism. Diabetes. 51(8):2341-7. doi: 10.2337/diabetes.51.8.2341.

[52] Torun, B. et al. (2002). Rural-tourban migration and cardiovascular disease risk factors in young Guatemalan adults. International Journal of Epidemiology. 31: 218-226

[53] Vales-Villamarín, C. et al. (2021). PPARc2 Pro12Ala Polymorphism is Associated in Children With Traits Related to Susceptibility to Type 2 Diabetes. Front. Pharmacol. 12:763853. doi: 10.3389/fphar.2021.763853

[54] Vergotine, Z. et al. (2014). Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa. BMC Genet. 15, 10, https://doi.org/10.1186/1471-2156-15-10

[55] Weiss, K., Ferrell, R., & Hanis, C. (1984). A New World syndrome of metabolic disease with a genetic and evolutionary basis. Yearbook Phys Anthropol 27:153-178.

[56] West, K. (1978). Epidemiology of Diabetes and its Vascular Lesions. Elsevier Biomedical Press, New York.

[57] Westman E. (2021). Type 2 Diabetes Mellitus: A Pathophysiologic Perspective. Front Nutr. 10;8:707371. doi: 10.3389/fnut.707371.

[58] Zárate, A., Saucedo, R., & Hernández, M. (2005) El receptor de peroxisoma-proliferador-activado gamma (PPAR?) es un factor de transcripción multigénico de versatilidad metabólica. Acta Med. 3(1):53-54.

[59] Zeggini, E. et al. (2005). Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples. Diabet Med. 22(12):1696-700. doi: 10.1111/j.1464-5491.2005.01717. x.

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