The genus Stephanopoides Keyserling (Araneae: Thomisidae: Stephanopinae) is reported from Panama for the first time. Males and females of two species, S. brasiliana Keyserling and S. simoni Keyserling, previously known only from South America, were found in Panama. Illustrations for both sexes and a key to their identification are presented. In addition, we present the first records of S. simoni Keyserling from Peru and consider Synema jocosum Banks (Thomisidae: Misumeninae) to be a junior synonymy of S. simoni Keyserling.