The text proposes an approach to semiotics theory applied to the study and analysis of creative processes (poietics) and reflections about art (esthetics). On the basis of one of the founding epistemological theories, “Plato’s theory of ideas”, which establishes an incisive distinction between the reality of the sensible world and the comprehensible world, the text presents Charles Sanders Peirce’s “Theory of Semiosis” as an alternative that transcends this differentiation. Particularly we concentrate on his theory of abduction as a way that opens possibilities for an effective conceptual and reflexive approach to artistic creation. We also explore other epistemological resources of Peircean semiotics capable of revealing and validating aspects of creative processes that are not traditionally considered by other epistemological models applied to the arts.