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Twenty-five years after Panamanian administration of the Canal, the country celebrates its achievements in sovereignty and development. However, in the current geopolitical context, threats to its control are resurfacing. A group of Republican congressmen in the United States has promoted the “Panama Canal Buyback” bill, with the support of President-elect Donald Trump, who has expressed his intention to regain control of the Canal. We have initiated an investigation into the role of the Canal not only as a key infrastructure but also as a symbol of national identity and a cornerstone of Panamanian sovereignty. From a historical and strategic perspective, it is argued that the response to these challenges must transcend confrontation and be based on active diplomacy, South- South cooperation, and the strengthening of international alliances. In this way, Panama can consolidate its position as a sovereign actor in the management of its most valuable resource and prevent its history from once again being defined by external interests