This paper explained how the Calumny in criminal matters has been understood in Panamá. First, the theory about the calumny was studied. The Law was also interpreted based on the exegetical method of legal interpretation. Finally, the Panamanian criminal jurisprudence on this crime against honor was analyzed. Calumny was also explained in the Panamanian Criminal Law. For this, techniques of bibliographic revision, of research of Law and of analysis of jurisprudence were used. It was concluded, among others, that the Panamanian Criminal Chamber has said that Calumny is only criminally prosecuted if it has been made with dolus.